刘再朋教授治疗复发性口腔溃疡的经验

目的：总结全国名老中医刘再朋教授治疗复发性口腔溃疡经验。方法：跟随刘再朋教授学习,整理其临床经验。结果与结论：刘再朋治疗口腔溃疡应重脾肾,以虚为本,实为标,内注重治本,外注重局部用药,防治结合,以防为主。     

相火致病理论探讨

相火致病理论是以相火学说为基础,结合临床观察,经归纳梳理而提出了从相火角度探讨发病机制的医学假说。文章首先简述相火理论发展历史,然后分别从相火含义、致病因素、致病原理、治疗思路四个方面阐明了相火致病理论的观点。     

情志因素与不孕症相关性探讨

阐述了中医学对情志因素致病的重要性及对不孕症影响的认识,认为情志因素致不孕症与妇女的生理心理特点有关,主张对不孕症的治疗应注重从肝论治。     

淡漠型甲亢中医辨治思路初探

淡漠型甲亢是甲状腺功能亢进症的一种特殊类型,其发病机制尚不明确,通过结合现有文献研究和临床资料,对淡漠型甲亢的发病机制、临床表现和中医辨治思路进行初步探讨。     

应用GSX高效辐射烧伤治疗机治疗大面积表皮缺损性疾病患者的疗效观察

目的观察GSX高效辐射烧伤治疗机治疗大面积表皮缺损性疾病患者的临床效果。方法选择2007年10月～2009年3月收治的大面积表皮缺损性疾病患者30例，随机分为两组，其中15例应用GSX高效辐射烧伤治疗机，持续照射，为治疗组，另外15例应用红外线照射，20min／次，2次／d，为对照组，在其他治疗方案均相同的情况下，分别观察两组患者创面感染情况、渗液持续时间以及治愈天数。结果治疗组创面细菌培养阳性率（13．3％）明显低于对照组（60．0％），治疗组渗液持续时间（7．5±1．6）d短于对照组（10．8±1．5）d，创面愈合时间治疗组（19．0±3．9）d明显短于对照组（23±4．7）d，P均〈0．01，两组比较差异有统计学意义。结论应用GSX高效辐射烧伤治疗机治疗大面积表皮缺损性疾病患者创面愈合快，感染率低，减轻了医护人员的工作量，是提高皮肤科大面积表皮缺损性疾病救治成功率的有效措施。     

糠醛精制过程的数学模型与优化

根据糠醛精制过程的机理分析和操作经验,建立了过程的静态数学模型。这些模型包括:精制油收率模型、精制油粘度模型以及精制油粘度指数模型。交叉验证的结果表明,所建模型的精度较高。提出了在精制油质量指标满足要求的前提下,以精制油收率最高为目标的糠醛精制过程操作优化策略,研究了不同工况下的操作条件。仿真研究与计算机离线指导生产结果都表明,本文提出的优化策略,可以提高精制油收率1～2%,具有明显的经济效益。     

从“脑为元神之府”探讨中风急性期的辨治方略

文章主要阐述中风病的辨治方略,提出中风急性期作为急性脑梗死的一种,治疗当从脑论治,并从"脑为元神之府"学说来论证"通府以复元神"的理论依据,笔者认为补气活血法、化瘀通腑法、豁痰开窍法等皆属于"通法"的综合应用,是治疗中风病的最佳选择。从"脑为元神之府"的理论钩玄、中风病因病机及复元醒脑汤组方治疗三方面来阐述中风急性期的中医辨治方略,讨论中风病急性期的治疗,并论证了"通府以复元神"的理论依据,以期为中风病的临床治疗提供参考。     

Gain Modulation of Cholinergic Neurons in the Medial Septum‐Diagonal Band of Broca Through Hyperpolarization

Hippocampal network oscillations are important for learning and memory. Theta rhythms are involved in attention, navigation, and memory encoding, whereas sharp wave‐ripple complexes are involved in memory consolidation. Cholinergic neurons in the medial septum‐diagonal band of Broca (MS‐DB) influence both types of hippocampal oscillations, promoting theta rhythms and suppressing sharp wave‐ripples. They also receive frequency‐dependent hyperpolarizing feedback from hippocamposeptal connections, potentially affecting their role as neuromodulators in the septohippocampal circuit. However, little is known about how the integration properties of cholinergic MS‐DB neurons change with hyperpolarization. By potentially altering firing behavior in cholinergic neurons, hyperpolarizing feedback from the hippocampal neurons may, in turn, change hippocampal network activity. To study changes in membrane integration properties in cholinergic neurons in response to hyperpolarizing inputs, we used whole‐cell patch‐clamp recordings targeting genetically labeled, choline acetyltransferase‐positive neurons in mouse brain slices. Hyperpolarization of cholinergic MS‐DB neurons resulted in a long‐lasting decrease in spike firing rate and input‐output gain. Additionally, voltage‐clamp measures implicated a slowly inactivating, 4‐AP‐insensitive, outward K⁺ conductance. Using a conductance‐based model of cholinergic MS‐DB neurons, we show that the ability of this conductance to modulate firing rate and gain depends on the expression of an experimentally verified shallow intrinsic spike frequency‐voltage relationship. Together, these findings point to a means through which negative feedback from hippocampal neurons can influence the role of cholinergic MS‐DB neurons. © 2016 Wiley Periodicals, Inc.     

Epidemiology of bus fires in mainland China from 2006 to 2015

Objective

This study analyses the epidemiological characteristics of bus fires in mainland China over the past 10 years to develop prevention strategies and emergency procedures for such incidence and the resulting casualties.