灯盏细辛对青光眼神经保护作用的临床研究

目的　评价灯盏细辛对眼压已控制的青光眼神经保护作用。方法　采用前瞻性、随机、双盲、安慰剂对照的研究方法 ,将眼压已控制的中晚期青光眼患者共 45例 ( 4 5眼 ) ,分层随机分为年龄匹配的灯盏细辛治疗组 ( 2 3例 )和安慰剂对照组 ( 2 2例 )。治疗组口服灯盏细辛 (EBHM) 2片 ,3次 /d ,对照组口服安慰剂 ,连续 6个月 ,每月复诊 1次。治疗前及每月复诊均检查矫正视力、眼压、视乳头杯盘比 (C/D)、自动静态阈值视野、血压和脉搏。结果　EBHM组与对照组在 6个月中平均眼压分别为 14 17mmHg± 2 5 0mmHg( 8～ 2 1mmHg)和 14 5 2mmHg± 1 94mmHg( 8～ 19mmHg) (P =0 5 98)。治疗 6个月后EBHM组平均敏感度 (MS)增加 1 42dB ,对照组MS下降 0 95dB(P =0 0 0 0 )。EBHM组和对照组视野进步率分别为 5 6 5 2 %和 4 5 5 % (P =0 0 0 1)。结论　灯盏细辛为一安全、无毒副作用的中草药 ,具有提高青光眼患者MS和部分改善原有视野缺损的作用 ,可作为视神经保护剂应用于治疗眼压已控制的青光眼。     

麻仁润肠口服液对肠道及排便的作用的实验研究

本文就麻仁润肠口服液的药理作用急性毒性进行了实验研究。药效实验表明，麻仁润肠口服液对结失水型便秘小鼠的排便功能有促进作用，可使排便点数增加，且能明显增强胃肠推进功能。对小鼠的肠管含水量有增加作用，在肠水分增加尤为明显。麻仁润肠口服液对离体兔肠平滑肌的收缩力和频率无影响。急性毒怀实验表明，小鼠胃经最大耐受量为６０ｇ生药／ｋｇ体重，为临床一次无影响。急性毒性实验表明：小鼠一次腹腔注射本品的ＬＤ５０是２     

芫花宫颈栓的制备研究

本实验对芫花的提取工艺、剂型进行了研究,将芫花提取物制成宫颈栓,改变了给药途径,解决了经羊膜注射给药给患者带来的痛苦,局部用药血药浓度大,引产时间缩短,制备工艺简单,成本低,易于推广。     

Histopathological and ultrastructural changes in liver tissue from burned patients

Histopathological studies were made on samples of liver and spleen tissue taken post mortem from 59 patients with severe burns. Samples from 8 patients were also studied using the transmission electron microscope. The main pathological findings were degeneration and necrosis of hepatic cells and proliferation of Kupffer cells showing active phagocytosis. Their causes in relation to the time of death after burning and severity of injury have been discussed. The proliferation of Kupffer cells may be a compensatory reaction to the severe splenic injury seen in the patients.     

急性胆管炎胆汁前列环素、血栓素的变化及茵陈胆道汤对其影响的研究

本文采用放射免疫法对２组兔和１ｌ例胆管结石术后病人服菌陈胆道汤之前、中、后的胆汁测定ＰＧＩ２与ＴＸＡ２和稳定代谢产物６—ｋｅｔｏ—ｐＧＦｌａ与ＴＸＢ２及两者之比值，观察三值的变化，探讨茵陈胆道汤对其影响，为胆管结石和胆管炎症的防治提供实验依据。结果显示：急性胆管炎组兔胆汁６—ｋｅｔｏ—ＰＧＦｌａ与ＴＸＢ２较实验对照组明显增高，６—ｋｅｔｏ—ＰＯＦｌａ／ＴＸＢ２明显降低。胆管结石术后病人服茵陈胆道汤至停药７天，胆汁中６—ｋｅｔｏ—ＰＧＦｌａ与ＴＸＢ２较服药前明显降低，停药２天６—ｋｅｔｏ—ＰＧＦｌａ／ＴＸＢ２较服药前增高。结果认为：①胆汁ＰＧＩ２的增高对急性胆管炎的发生和胆管结石的形成有着密切的关系；②ＰＧＩ２／ＴＸＡ２失衡，ＴＸＡ２）增加在急性胆管炎中的毒性作用十分重要；③茵陈胆道汤有降低ＰＧＩ２和ＴＸＡ２的作用，是防治胆管结石的胆管炎症的有效中药方剂。     

解毒化瘀汤治疗温病内毒素血症临床研究

解毒化瘀汤治疗温病内毒素血症临床研究结果表明,该方有抗炎作用,对内毒素有拮抗作用,能保护组织器官,特别是心、肝、肾等重要器官免受内毒素损害,能调节免疫功能,对血浆内毒素的清除作用非常显著,有直接对抗或抑制内毒素之抗原作用,对内毒素之生物活性有灭活作用,为临床治疗内毒素血症开拓了一条新的有效途径。     

Carcinosarcoma of the salivary gland

A 59-year-old woman had carcinosarcoma of the salivary gland. Salivary gland tumors of this type are aggressive and rare. Most patients die of the tumor, but surgical cure has been reported in one case.     

揆度求奇恒 黄溪无止境——黄山名士陈无咎医学思想撷析

简述民国时期黄山名士陈无咎的传奇经历,分析其医学思想。治学宗从《内经》,实践崇尚揆度;弘扬丹溪学说,创办中医院校;主张取长补短,融汇中西医学,旨在发展中医。     

Is lymph node dissection necessary for resectable intrahepatic cholangiocarcinoma? A systematic review and meta-analysis

BackgroundThe objective of this meta-analysis was to evaluate the effectiveness and safety of lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC).MethodsA literature search with a date range of January 2000 to January 2018 was performed to identify studies comparing lymph node dissection (LND+) with non-lymph node dissection (LND-) for patients with ICC. The LND + group was further divided into positive (LND + N+) and negative (LND + N-) lymph node status groups based on pathological analysis.Results13 studies including 1377 patients were eligible. There were no significant differences in overall survival (OS) (HR 1.13, 95% CI 0.94–1.36; P = 0.20), disease-free survival (DFS) (HR 1.23, 95% CI 0.94–1.60; P = 0.13), or recurrence (OR 1.39, 95% CI 0.90–2.15; P = 0.14) between LND + group and LND-group. Postoperative morbidity was significantly higher in the LND + group (OR 2.67, 95% CI 1.74–4.10; P < 0.001). A subset analysis showed that OS was similar between LND + N- and LND-groups (HR 1.13, 95% CI 0.82–1.56; P = 0.450). However when comparing, OS of the LND-group to the LND+N+ group there was a significant increase in OS for the LND-group (HR 3.26, 95% CI 1.85–5.76; P < 0.001).ConclusionsLND does not seem to positively affect overall survival and is associated with increased post-operative morbidity.     

玉林市2002—2010年肺结核流行状况分析

摘要：目的了解广西玉林市活动性肺结核流行现状。方法根据2002年以来玉林市结核病防治机构初诊病人登记、结核病人登记、季报表、月报表、结核病网络专报系统对玉林市2002～2010年活动性肺结核流行状况进行分析。结果玉林市2002—2010年共登记活动性肺结核病人30950例,年均活动性肺结核登记率为55．58／10万;其中共登记新涂阳病人12159例,年均新涂阳登记率为21．83／10万;复治涂阳病人共1568例,年均复治涂阳病人登记率为2．82／10万;活动性发病率由2006年的75．66％下降到2010年的51．87％;复治涂阳病人年登记率由2006年的33．27％下降到2010年的1．62％。全年均有发病,3月发病最多,1月份发病最少。男性比女性多发,发病主要是农民,各县发病平均。结论玉林市结核病防治工作成效显著,今后应加强农村的结核病防控工作。