烧伤大鼠血清对血管内皮细胞通透性的影响

加深入阐明严重烧伤早期全身血管通透性增加继而引直民早期损害的发生机制，本实验应用培养于微孔滤膜上的小牛瞌 及皮细胞单层所构成的选择性通透屏障模型，观察了３０％Ⅲ度烧伤大鼠血清对其影响，结果发现，烧伤早期烧伤血清刺激后ＥＣ单层对Ｈａｎｋｓ液或白蛋白液滤过流量、滤过系数均明显增加。     

高压氧中毒对小鼠肺毛细血管细胞色素氧化酶活性的影响

采用超微结构细胞化学和计算机图象定量分析方法，测量计算了高压下氧中毒小鼠肺毛细血管线粒体、线粒体细胞色素氧化酶二维形态学和三维立体学参数。结果表明，小鼠暴露于０．５ＭＰａ高压氧后，肺毛细血管线粒体二维形态学和三维立体学参数的值没有发生变化，但线粒体细胞色素氧化酶的活性明显降低。     

Effect of Bendazac Lysine on lens and retina in diabetics

The possible beneficial effects on the lens and retina which Bendazac Lysine may have in the treatment of adult diabetic patients were investigated. Twenty patients, ranging in age from 54.80 ± 5.86 years old, were studied. The average duration of the diabetes was 11.32 ± 4.10 years. Thirteen patients had background retinopathy. The metabolic controls carried out during the study were satisfactory (HbA1<11%). Bendazac Lysine (500 mg three times a day) was administered for 6 months. Blood-retinal barrier permeability (VPR and VPRt) and lens transmittance (t) were evaluated prior to and 6 months after treatment by fluorophotometry. No statistically significant differences between the pre- and post-treatment values of the retina permeability were observed, however, there was a statistically significant improvement (p<0.05) (initial value: t= 0.813 ± 0.040 and final value: t=0.823 ± 0.037) in the lens transmittance. The authors conclude that Bendazac Lysine has a beneficial effect on the lens in the diabetic adult although no improvement in the permeability of the blood-retinal barrier has been observed.     

胰腺癌病人肠道通透性改变及其与机体组成的关系

目的:观察胰腺癌病人肠道通透性与机体组成的改变,并初步探讨两者间的关系.方法:以前瞻、随机和对照的方法,选取确诊胰腺癌首次入院的病人及健康志愿者各15例,作为试验组和对照组,测定尿乳果糖/甘露醇(L/M)比值、血清肿瘤坏死因子-α(TNF-α)和机体组成成分,并对试验组的肠道通透性L/M比值与血清TNF-α水平、机体组成之间的相关性进行分析.结果:①试验组尿L/M比值为0.331±0.343显著高于对照组0.129±0.136(P《0.05);血清TNF-α水平显著高于对照组(P《0.05).②试验组肌肉群重量显著低于对照组(P《0.05)、蛋白质重量极显著低于对照组(P《0.01)、而脂肪、水分、无机盐重量略轻于对照组,两组间差异无显著性意义.③试验组尿L/M比值与血清TNF-α水平呈极显著性正相关(P《0.01);尿L/M比值与蛋白质、脂肪呈极显著性负相关(P《0.01),与水分呈极显著性正相关(P《0.01);而试验组血清TNF-α浓度与蛋白质、脂肪呈极显著性负相关(P《0.01)、与水分呈极显著性正相关(P《0.01).结论:胰腺癌病人肠道的通透性增加,机体组成有显著改变,两者间密切相关.这可能与血清TNF-α水平的升高有关.     

气相色谱用于肠通透性监测的研究

作者采用国产气相色谱及９２０２微机数据处理系统，对临床患者和实验动物肠通透性改变进行监测。该方法以甘露醇（Ｍ）和乳果糖（Ｌ）为探针，用气相色谱检测尿中糖分泌率及Ｌ／Ｍ比值。结果显示，测定标准品Ｍ和Ｌ随进样量增加而呈线性改变，与国外学者报道一致。比较不同浓度进口与国产乳果糖，证明二者在研究肠通透性方面高度相关（ｒ＝０．９９）。检测急性胰腺炎并发感染动物的尿标本，发现乳果糖大量排出，Ｌ／Ｍ值明显增加。作者认为，气相色谱为一行之有效的方法用于肠通透性监测，有助于临床上对内源性感染及脓毒症的早期诊断。     

Changes in the microcirculation in rats with experimental trigeminal neuralgia

Laboratory of Pathophysiology of Pain and Laboratory of General Pathology of the Microcirculation, Research Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 1, pp. 9–11, January, 1991.     

Adenosine protects ultrastrueture of isolated rat lungs against fat emulsion injury

In isolated rat lungs subjected to fat emulsion damage, a model simulating adult respiratory distress syndrome, we have previously reported that adenosine (ADO) reduces pulmonary vascular resistance (PVR) and the fluid filtration rate (FFR). In the present study the aim was to examine morphologically this effect of ADO. Two groups of isolated rat lungs were subjected to the injury. Marked and significant differences were found between the groups; in lungs not given ADO, FFR and airway pressure were higher and, as evaluated by electron microscopy, the endothelial lining was thin and partly disrupted. The epithelial cells of the alveolar walls were also partly disrupted and the alveolar septa were split enclosing interstitial edema. In lungs receiving ADO from the onset of exposure to fat emulsion, FFR was lower and ultrastructure did not differ from non–injured non–treated controls perfused for the same length of time.     

直接甲醇燃料电池用阻醇质子导电聚乙烯醇-聚苯乙烯磺酸共混膜

制备了聚乙烯醇 (PVA)与聚苯乙烯磺酸 (PSSA)的共混膜 ,并研究了膜的组成、热处理温度、甲醇水溶液浓度等对膜电导率和甲醇透过率的影响。与目前普遍使用的NafionTM膜相比 ,这种由阻醇材料PVA与离子交换材料PSSA共混后形成的聚合物膜既能提高阻醇性能 ,又具有一定的电导率。一种以聚苯乙烯磺酸含量为 17%的膜 ,其电导率可达 3× 10 -3 S·cm-1,但甲醇透过率P仅为 2× 10 -8cm2 ·s-1。如果以σ/P为综合指标 ,则此膜的综合性能比NafionTM膜高约 4 0倍