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951.
李阳春 《南通大学学报(哲学社会科学版)》2002,18(2):117-120
八十年代初中期 ,中国戏剧积极拓展我国传统戏剧的时空观、写意性特征 ,大胆借鉴西方现代戏剧的荒诞化、意象性技巧 ,出现了探索创新、多元发展的崭新局面。其中对“三一律、一堵墙”戏剧观的突破 ,运用意识形象外显人物的内心世界 ,嫁接多种艺术手段将现实时空转化为艺术时空 ,是新时期戏剧艺术探索最突出的三项成就。而过分强调形式技巧 ,脱离观众欣赏习惯 ,致使演出市场萎缩 ,观众锐减 ,无疑是新时期戏剧艺术探索中面临的最大困顿。 相似文献
952.
甲基强的松龙对低温保存大鼠肝脏的保护作用 总被引:2,自引:1,他引:1
应用Wistar大鼠肝脏离体灌流模型,用CMU—1号液,含有甲基强的松龙的CMU—1号液,以及缺血前预用甲基强的松龙后再用CMU—1号液分别对肝脏进行灌洗保存。检测LDH、ALT、肝组织匀浆SOD活性和MDA含量,并观察肝组织结构。结果表明:甲基强的松龙对低温保存的离体大鼠肝脏具有保护作用 相似文献
953.
本文收集1992年1月至1995年5月在我科作肝动脉化疗栓塞术和肝动脉化疗灌注术的中晚期肝癌160例,将每例病人的肝动脉造影所见与临床资料及随访结果一起进行分析。 相似文献
954.
眼底荧光血管造影中按摩内关与合谷穴对恶心和呕吐的影响 总被引:3,自引:0,他引:3
观察按摩内关和合谷穴对上有底荧光血管造影中恶心和呕吐的影响。眼底荧光血管造影中发生恶心和呕吐的60例患者随机分为治疗组和对照组。治疗组按摩一侧或双侧内关穴和合谷穴;对照组未进行治疗,在发生恶心患者中,治疗组30例中发生哎者2例;对照组发生呕吐者9例,两组的发生率有显著差异 相似文献
955.
Eiji Takeuchi Yuji Nimura Shin-ichi Mizuno Hideaki Suzuki Shinsuke Iyomasa Masaki Terasaki Hiroshi Kuriki Keiko Tamiya-Koizumi Shonen Yoshida 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(3):254-262
Hepatocyte regeneration has been widely investigated, with the mitotic index and the incorporation of [3H]thymidine being used as regeneration markers. We focused on the induction of DNA replication enzymes, particularly DNA polymerases
(pol) α, δ, and ε. Using rat models, we have shown that the activity of pol α in crude liver extract well represents the regenerating
capacity of hepatocytes. Using pol α as an indicator, we analyzed liver regeneration in rat models under various conditions:
obstructive jaundice, external or internal biliary drainage, and the obstruction of portal vein branches. It has been revealed
that the ligation of the common bile duct alone induces a certain amount of hepatocyte proliferation. It was striking that
external biliary drainage suppressed regeneration capacity in cholestatic rat liver after partial hepatectomy. The strong
regeneration in nonligated lobes induced by portal branch ligation was similar to the liver regeneration seen after partial
hepatectomy with respect to the induction of DNA polymerases. Taken together, the aspects of DNA replication, particularly
the induction of DNA polymerases, may contribute to shedding new light on the regeneration of human liver.
This work was supported in part by a Grant-in-Aid for General Scientific Research and for Cancer Research from the Ministry
of Education, Science and Culture, Japan, and by grants from the Uehara Memorial Foundation 相似文献
956.
Papillitis and vasculitis of the arteria spinalis anterior as complications of hepatitis C reinfection after liver transplantation 总被引:1,自引:0,他引:1
T. Propst Albert Propst Karin Nachbaur I. Graziadei Hans Willeit Raimund Margreiter Wolfgang Vogel 《Transplant international》1997,10(3):234-237
It is well known that hepatitis C virus (HCV)-related chronic liver disease may be associated with various immunological
disorders including mixed cryoglobulinemia, which is accompanied by cutaneous vasculitis, arthralgias, membranoproliferative
glomerulonephritis, and neuropathy in association with cryoprecipitable immune complexes in serum. We describe here the first
case of central nervous system HCV infection with evidence of the virus in the cerebrospinal fluid in association with cryoglobulinemia
in a patient who developed recurrent episodes of papillitis and vasculitis of the arteria spinalis anterior after liver transplantation.
Received: 3 September 1996 Received after revision: 13 November 1996 Accepted: 6 December 1996 相似文献
957.
A rat model of monitoring liver allograft rejection 总被引:5,自引:0,他引:5
Timi Martelius Heikki Mäkisalo Krister Höckerstedt Eero Taskinen Irmeli Lautenschlager 《Transplant international》1997,10(2):103-108
Rat models are often used to study liver allograft rejection. We have established a model for rat liver allograft rejection,
monitored by fine needle aspiration biopsy (FNAB), in the strain combination PVG-to-BN with a mean survival time of 37 ± 20
days. In this model, we observed acute rejection with an intense peak of lymphoid blasts and lymphocyte-dominated inflammation
in the FNAB [9.1 ± 3.0 corrected increment units (CIU)], and an eventual increase in macrophages (up to 4.2 ± 4.4 CIU), together
with fibrosis and parenchymal necrosis in the graft. Markers of immune activation, such as an increase in IL-2-receptor (from
1 % ± 2 % to 21 % ± 13 %) and class II (from 20 % ± 9 % to 43 % ± 13 %) expressing lymphoid cells and induction of ICAM-1
in the graft, were consistent with the overall cellular response. The FNAB correlated well with parallel graft histology.
In this rat model, the atraumatic monitoring makes a close follow-up possible without having to sacrifice the experimental
animals. This saves work, animals, and costs in the study of liver rejection.
Received: 2 July 1996 Accepted: 28 October 1996 相似文献
958.
P. E. Wallemacq Raymond Reding Etienne M. Sokal Jean Ville de Goyet Stéphane Clement de Clety Véronique Van Leeuw Marc De Backer Jean-Bernard Otte 《Transplant international》1997,10(6):466-470
Pediatric liver transplant recipients constitute a population characterized by a particularly unpredictable and poor bioavailability
of cyclosporin (CyA). Even though several adult studies show that the new oral formulation of CyA, Neoral (NEO), produces
better bioavailability and blood level predictability, few data describe its pharmacokinetics in children. We performed a
complete analysis of the pharmacokinetics of NEO in ten small children after primary liver transplantation. Three pharmacokinetic
profiles were set up with data obtained from tests taken during i. v. administration of CyA, after the first oral NEO dose,
and after the last NEO dose before discharge from the hospital. The mean half-lives obtained were 8.1, 7.7, and 6.9 h, respectively,
and the bioavailabilities were 22 % and 21 % for the first and last NEO doses. A large interpatient variability was observed.
This was due, in part, to episodes of diarrhea that interfered with the pharmacokinetic evaluation and, in part, to the variability
of post-transplant hepatic function. There was a good correlation between CyA trough levels and their related AUCs for both
NEO profiles (r = 0.93 and r = 0.74, respectively). We conclude that, even though the pediatric OLT population remains more unpredictable than that of
adults, NEO has a relatively rapid half-life and a remarkably improved bioavailability.
Received: 29 November 1996 Received after revision: 10 April 1997 Accepted: 15 May 1997 相似文献
959.
J. Friedrich Massimo Malago Reinhard Lange Josef Kemnitz Filip Danninger Jochen Erhard 《Transplant international》1997,10(3):245-246
We report on the successful regrafting of a transplanted liver. The donor liver was first grafted into a patient suffering
from cryptogenic cirrhosis; the patient died 1 day after the elective transplantation of cerebral bleeding. The well-functioning
graft was harvested again and transferred to our institution. After another 12 h of cold ischemia, the liver was reperfused
in an urgently registered patient with recurrence of hepatitis B in his first graft. The transplantation was successfully
performed and the patient is now doing well, more than 5 months after regrafting with the reused liver.
Received: 21 October 1996 Received after revision: 9 January 1997 Accepted: 27 January 1997 相似文献
960.
T. Scholz Ø. Mathisen A. Bergan S. Osnes R. Innes T. Pedersen A. O. Aasen O. Søreide 《Transplant international》1997,10(3):180-184
We have introduced and evaluated several modifications of the conventional venovenous bypass (VVBP) in 29 adult patients
undergoing liver transplantation (OLT). A percutaneous technique for insertion of a jugular venous return cannula and a femoral
vein cannula was applied. The inferior mesenteric vein (IMV) was used for splanchnic decompression, which facilitated dissection
of the recipient liver and allowed portal anastomosis to be performed without disconnecting the portal bypass. A heat exchanger
was introduced into the bypass circuit to prevent heat loss. The percutaneous technique prevented complications related to
dissection in the axilla and groin. Hemodynamic characteristics corresponded to those found using the traditional technique.
Complications related to the VVBP were seen in only one patient in whom the femoral catheter was accidentally introduced into
the femoral artery. We conclude that percutaneous cannulas, use of the IMV for splanchnic decompression and the introduction
of a heat exchanger offer significant benefits and that they are safe and reliable.
Received: 23 August 1996 Received after revision: 14 January 1997 Accepted: 27 January 1997 相似文献