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目的 探讨经颧骨-颅中窝入路手术治疗累及颅中窝的颅底肿瘤的疗效。方法 回顾性分析2016年3月至2021年1月经颧骨-颅中窝入路手术治疗的16例累及颅中窝的颅底肿瘤的临床资料。结果 肿瘤全切除9例,次全切除7例。术后病理示脑膜瘤7例,软骨肉瘤4例,骨肉瘤、浆细胞瘤、听神经瘤、三叉神经鞘瘤、血管外皮细胞瘤各1例。术后平均随访(36.3±26.9)个月;MRI复查未出现残留肿瘤再生长或复发;术后6个月KPS评分(75.5±12.4)分,mRS评分0~2分16例;末次随访,15例面神经功能为House-Brackmann分级1级,2级1例。结论 对于累及颅中窝的颅底肿瘤,经颧骨-颅中窝入路手术治疗效果良好。 相似文献
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A 58-year-old female was referred to our department with intermittent suffocation for 1.5 years, aggravated for a month. 1.5 years before she developed oral ulcer, raynaud phenomenon, proteinuria, bilateral pleural effusion, ANA and anti-dsDNA positive. This patient was diagnosed with systemic lupus erythematosus (SLE). After given hormones, hydroxychloroquine sulfate (HCQ), her symptom relieved soon. The patient stopped her pills 1 year ago. One month ago, she had chest tightness, increased urine foam, and suffered from oliguria. Her admission medical examination: blood pressure (BP) 130/80 mmHg, conjunctiva pale, and lower lung breath sounds reduced. There was no tenderness, rebound pain and abdominal muscle tension in the abdomen. Liver and spleen rib inferior, mobile dullness negative, and lower extremity edema. Blood routine tests were performed with hemoglobin (HGB) 57 g/L. Urine routine: BLD (3+). 24-hour urinary protein 3.2 g. serum albumin 20.5 g/L, C-reactive protein (CRP) 12.85 mg/L, erythrocyte sedimentation rate (ESR) 140 mm/h. Antinuclear antibody (ANA) (H)1 ∶10 000;, anti-dsDNA antibody 1 ∶3 200;, anti-Smith antibody, anti-U1-snRNP / Sm antibody were positive, blood complement 3(C3) 0.43 g/L, complement 4(C4) 0.07 g /L. Anticardiolipin antibody (ACL), anti-β2-GP1;, lupus anticoagulant (LA) were negative, HRCT suggested bilateral medial pleural cavity product liquid. Admission diagnosis: SLE lupus nephritis, anemia, pleural effusion, and hypoproteinemia. We treated her with methylprednisolone 1 000 mg×3 d;, late to 48 mg/d and cyclophosphamide 1.0 g, HCQ 0.2 g bid, gamma globulin 10 g×5 d. Day 2 of treatment;, this patient developed acute right upper quadrant pain, not accompanied by nausea, vomiting, blood stool and diarrhea. Antipyretic antispasmodic treatment was invalid, after the morning to ease their own abdominal pain. Day 4 of treatment, daytime blood HGB 77 g/L. Bilateral renal vascular ultrasound: bilateral renal artery blood flow velocity was reduced. The abdominal pain of the above symptoms recurred at night, BP was 120/80 mmHg, and no positive signs were found on abdominal examination. No abnormality was found in the vertical abdominal plain film. Blood routine examination: HGB 53 g/L, Plasma D dimer 2 515 μg/L;, amylase in hematuria was normal, the stool occult blood was negative. Abdominal computed tomography (CT): normal structure of right adrenal gland disappeared, irregular mass shadow could be seen in adrenal region, CT value was about 50 HU. Morphological density of left adrenal gland was not abnormal. The retroperitoneum descended along the inferior vena cava to the right iliac blood vessel and showed a bolus shadow. The density of some segments increased. The lesion involved the right renal periphery and reached the left side of abdominal aorta. Most lesions surrounded the inferior vena cava, the right renal vein and part of the small intestine. The boundary between the upper lesion and the vena cava was unclear. Iodine-containing contrast agent was taken orally. No sign of contrast agent overflowing was found in the abdominal cavity. Hematoma and exudative changes were considered in retroperitoneum. Conclusion of contrast-enhanced ultrasound of blood vessels: The retroperitoneal inferior vena cava (volume 3.5 cm×3.5 cm×1.5 cm) was hypoechoic and had no blood flow lesion. The adrenal gland had a high possibility of origin. Left renal vein thrombosis extended to inferior vena cava. According to the above data;, it was analyzed that the cause of retroperitoneal hematoma of the patient was left adrenal vein thrombosis caused by hypercoagulable state, which led to vascular rupture and hemorrhage caused by increased vascular pressure in adrenal gland. Therefore, on the basis of continuing to actively treat the primary disease, and on the basis of dynamic observation of no active hemorrhage for 3 days, the anticoagulant therapy was continued with 10 mg/d of apixaban. Clinical symptoms were gradually eased, HGB did not decrease. Two weeks later, the ultrasonic examination showed that the irregular cluster hypoechoic range behind the inferior vena cava was significantly smaller than that before (1.8 cm×1.2 cm×0.7 cm). Abdominal CT examination after 1 month showed that there was no abnormal morphological density of bilateral adrenal glands and basic absorption of retroperitoneal exudation. Adrenal hemorrhage is uncommon. SLE with adrenal hemorrhage is rarer. In SLE patients;, especially those complicated with APS, if abdominal pain accompanied by HGB decrease occurs, except after gastrointestinal hemorrhage, the possibility of adrenal hemorrhage should be warned. 相似文献
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目的探讨阴道分泌物功能酶检测联合常规镜检在阴道微生态变化中的应用价值。方法对来该院妇科门诊就诊的患者样本进行阴道分泌物功能酶和常规镜检联合检测,并对结果进行综合分析。结果在13 175例检测样本中,功能酶指标过氧化氢(H2O2)、白细胞酯酶(LE)、β-葡萄糖醛酸苷酶(GUS)、唾液酸酶(SNa)、凝固酶(GADP)阳性率分别为82.72%、79.97%、12.34%、15.63%、14.45%;H_2O_2阳性率随年龄增长呈上升趋势,差异有统计学意义(P0.05)。在阴道清洁度Ⅰ~Ⅱ度的样本中,H_2O_2、LE、GUS、SNa、GADP的阳性率分别为79.29%、73.38%、3.66%、3.46%、6.81%,SNa+H_2O_2、GUS+GADP、GUS+H_2O_2、GADP+H_2O_2的阳性率分别为3.11%、0.43%、5.83%、2.31%。结论阴道分泌物功能酶检测联合常规镜检可提示阴道微生态的早期改变,功能酶多指标联合分析有助于全面了解阴道微生态状况,对有效诊治阴道感染性疾病有重要的临床意义。 相似文献
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张令① 《中国初级卫生保健》2020,34(6):109-111
目的探讨透明帽辅助下胃镜食道异物取出术的临床效果及安全性。方法按随机数字表法将2018年1月—2019年2月就诊于驻马店市中心医院的94例食管异物者分为对照组与研究组各47例。对照组行常规电子胃镜取物,研究组行透明帽辅助下胃镜食道异物取出术。对比两组取物时间、异物取出成功率、黏膜损伤率、视野清晰度、患者耐受情况及并发症发生情况。结果研究组异物取出时间为(8.29±3.38)min,短于对照组的(15.15±4.68)min,差异有统计学意义;研究组异物取出成功率为97..87%,高于对照组的82.98%,黏膜损伤率为19.15%,低于对照组的38.30%,差异有统计学意义;研究组视野清晰度优于对照组,差异有统计学意义;研究组耐受优良率为82.98%,高于对照组的57.45%,差异有统计学意义;研究组渗血发生率为4.26%,低于对照组的17.02%,差异有统计学意义;两组穿孔发生率对比,差异无统计学意义。结论透明帽辅助下胃镜食道异物取出术视野清晰度较高,可有效缩短取物操作时间,改善患者耐受性,减轻食道黏膜损伤,减少渗血的发生,安全性较高。 相似文献
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目的探讨中晚期儿童肾透明细胞肉瘤(CCSK)的临床特点、诊治经过及预后特点。方法收集2014年1月至2017年12月在首都医科大学附属北京同仁医院儿科住院治疗的10例中晚期CCSK患儿的临床资料,对其临床特征、诊疗经过及预后情况等进行回顾性分析。结果1.临床特点:10例CCSK病例中男6例,女4例;中位发病年龄为32个月;7例为左侧CCSK,3例为右侧CCSK。初次诊断时Ⅲ期9例,Ⅳ期1例;其中4例初次诊断时误诊为肾脏其他肿瘤(40%,4/10例)。5例Ⅲ期病例治疗及随访过程中出现肿瘤复发及转移,主要远处转移部位为肺、骨、肝脏及脑。2.治疗及预后:10例中给予手术联合放疗及化疗者7例,未规范化治疗放弃者3例。中位随访时间33.5个月,7例存活,3例死亡,3年总生存率为65.6%。Ⅲ期患儿3年总生存率为74.1%,Ⅳ期患儿3年总生存率为0,Ⅲ期与Ⅳ期预后比较差异有统计学意义(χ^2=9,P=0.003)。5例复发病例中仅1例完全缓解,2例部分缓解,1例进展,1例死亡;3例无复发病例均完全缓解,且均为给予手术、化疗及放疗规范化治疗者。结论儿童CCSK初诊误诊率高,Ⅲ期病例治疗及随访过程中复发及远处转移风险高;Ⅲ期病例积极给予手术、化疗及放疗的规范化治疗,预后良好,而发生复发及远处转移者死亡率高。 相似文献
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目的探讨纳洛酮联合更昔洛韦治疗小儿病毒性脑炎的疗效及安全性。方法将2012年1月至2014年1月我院小儿病毒性脑炎患者60例随机分为观察组和对照组,对照组给予常规治疗,观察组给予纳洛酮联合更昔洛韦治疗,评估两组治疗效果及安全性。结果观察组患者总有效率明显高于对照组(P<0.05)。治疗后观察组患儿退热时间、头痛呕吐缓解时间、惊厥控制时间、意识恢复时间明显少于对照组(P<0.05)。结论纳洛酮联合更昔洛韦治疗小儿病毒性脑炎的疗效确切,副作用少,值得应用。 相似文献