中药内服配合皮肤外治法治疗痤疮350例免疫学改变及疗效分析

目的：探讨用中药内服配合皮肤外治法治疗痤疮的临床疗效及对免疫学指标的影响。方法：对350例痤疮患者采用中药辨证分型内服配合皮肤外治法治疗，检测其治疗前后免疫学指标。结果：中药内服配合皮肤外治法治疗痤疮疗效甚佳，痤疮患者的免疫学改变和治疗疗效有直接联系。     

Severe acne as a side effect of propranolol and nadolol in a migraineur

Beta-blockers have proven effective in the treatment of migraine. Dermatologic side effects are extremely rare. We report a patient with migraine who developed an acnelike dermatitis with two different beta-blockers with complete resolution of the acne upon discontinuation of each drug.     

Contemporary surgical treatment of hidradenitis suppurativa (HS) with a focus on the use of the diode hair laser in a case

Abstract

Hidradenitis suppurativa, a chronic recurrent disorder, characterized by painful, deep-seated nodules and abscesses commonly affecting the pilosebaceous-apocrine unit of the axillary, inguinal and mammary region in females, while the perianal area and buttocks are the prevalent sites in males. Its onset is after puberty, and may persist thereafter. Its exact aetiology is speculative. Follicular occlusion is the primary event leading to secondary inflammation, infection and destruction of the unit, ultimately affecting the adjoining subcutaneous tissue. Smoking and obesity may trigger or aggravate the condition. Stage of disease determines the mode of treatment. Medical treatment is valid in the early stage, but the results are transient. The early stage may warrant incision, and drainage of abscesses coupled with limited excision for locally recurring draining sinuses. While radical excision and healing with secondary intention, skin grafting, and flaps is recommended in advanced stages, laser therapy including the diode laser may prove a promising and innovative alternative.     

Therapeutic utility of antibacterial peptides in wound healing

Cationic antimicrobial peptides were first thought to fight infection in animal models by disintegrating bacterial peptides and later by inhibiting bacteria-specific intracellular processes. However, ever increasing evidences indicate that cationic peptides accumulate around and modulate the immune system both systemically and in cutaneous and mucosal surfaces where injuries and infections occur. Native and designer antibacterial peptides as well as cationic peptides, never considered as antibiotics, promote wound healing at every step of cutaneous tissue regeneration. This article provides an introductory list of examples of how cationic peptides are involved in immunostimulation and epithelial tissue repair, eliminating wound infections and promoting wound healing in potential therapeutic utility in sight. Although a few antimicrobial peptides reached the Phase II clinical trial stage, toxicity concerns limit the potential administration routes. Resistance induction to both microbiology actions and the integrity of the innate immune system has to be carefully monitored.     

小剂量泼尼松联合异维A胶丸治疗聚合型痤疮临床观察

目的探讨小剂量泼尼松联合异维A胶丸治疗中重度囊肿性痤疮的疗效。方法采用随机开放对照研究,入选患者78例,随机分为3组,C组予异维A胶丸0.5～1.0mg/(kg.d)和罗红霉素分散片300mg/d口服,A组在C组基础上同时予泼尼松20mg晨服,3周后泼尼松减为隔日晨服;B组在C组基础上口服吲哚美辛25mg3次/d,共5天,间隔5天重复使用,疗程均为6周。结果A,B,C三组痊愈率分别为74.07%,38.46%,32.00%,差异有显著性意义(P<0.05);有效率分别为92.5%,92.31%,88.00%,差异无显著性意义(P>0.05)。三组均未发现不可耐受副作用。结论小剂量泼尼松联合异维A胶丸治疗中重度囊肿性痤疮可以缩短疗程,提高痊愈率,是一种安全有效的方法。     

New photographic techniques for clinical evaluation of acne

Clinical evaluation of acne is usually based on direct visual assessment and ordinary flash photography, both of which are compromised by viewer subjectivity. It is difficult to accurately assess individual acne lesions and to observe early response to therapy. Standard flash photography has inherent limitations owing to the physics of light; it does not permit consistent visualization of subtle cutaneous characteristics like erythema or microcomedones, and it tends to blur distinctions between active inflammatory lesions and older hyperpigmented macules. Over the last decade there has been increasing interest in newer techniques aimed at increasing the accuracy and objectivity of acne evaluation. These include parallel‐polarized light photography, cross (or perpendicular)‐polarized light photography, videomicroscopy, and fluorescence photography. This article will review the advances of the past decade and summarize new techniques to evaluate acne lesions. Moreover, findings of a study that evaluated the course of individual acne lesions and the effects of adapalene gel 0.1% on inflammatory and non‐inflammatory acne lesions will be viewed. In this study, the use of parallel‐polarized and cross‐polarized photography, in combination with videomicroscopy and sebum production measurement, provided objective, detailed information on the evolution of different variable acne lesions and their response to adapalene gel 0.1%. Adapalene treatment produced rapid resolution of inflammatory and non‐inflammatory lesions, and inhibited formation of new lesions. Sebum secretion rates also declined during treatment. Use of the new assessment techniques proved to be a valuable, non‐invasive and reliable method of assessing acne vulgaris and its response to treatment.     

Technologies for cutaneous exfoliation using salicylic acid

The use of superficial chemical peels to achieve cutaneous exfoliation is valuable in maintaining a smooth skin texture. One of the preferred chemical modalities to perform superficial peels is salicylic acid. Salicylic acid can used to safely peel many different skin types because of its ability to self-neutralize. In addition, it is beneficial in the treatment of acne because of its comedolytic effect. The methodology for salicylic acid peeling is presented.     

红蓝光联合水杨酸治疗面部痤疮的临床效果

探究在面部痤疮患者中应用红蓝光联合水杨酸治疗的临床效果。方法 选取2023年1月-6月我 院皮肤科收治的80例面部痤疮患者为研究对象，采用随机数字表法分为对照组和研究组，每组40例。对照 组实施单纯红蓝光治疗，研究组实施红蓝光联合水杨酸治疗，比较两组痤疮症状评分、临床疗效、 不良反应发生情况、心理状态及治疗满意度。结果 研究组治疗4周后痤疮GAGS评分均优于对照组 （P ＜0.05）；研究组治疗总有效率为95.00%，高于对照组的70.00%（P ＜0.05）；研究组不良反应发生率 为7.50%，低于对照组的20.00%（P ＜0.05）；研究组治疗后SAS评分、SDS评分均低于对照组（P ＜0.05）； 研究组治疗满意度为92.50%，高于对照组的72.50%（P ＜0.05）。结论 在面部痤疮患者中应用红蓝光联合 水杨酸治疗的临床效果良好，可有效改善患者的痤疮症状，有利于减轻其不良情绪，且不良反应发生率较 低，患者满意度较高。     

阿达帕林凝胶治疗寻常痤疮临床观察

目的 :观察 0 1%阿达帕林凝胶治疗寻常痤疮的临床疗效和安全性。方法 :16 0例寻常痤疮患者 ,分别给予外涂 0 1%阿达帕林凝胶 (80例 )及 0 0 2 5 %全反维A酸凝胶 (80例 )。根据治疗前后炎性损害和非炎性损害总数减少的百分率评价疗效。结果 :两组痊愈率、显效率、有效率均无统计学差异 ,阿达帕林组不良反应率明显低于全反维A酸组。结论 :0 1%阿达帕林是一种局部治疗寻常痤疮的有效的安全的药物     

Effects of oral antibiotic roxithromycin on quality of life in acne patients

Macrolides are effective for inflammatory acne, but there are not many studies on roxithromycin. In this study, patients with acne were surveyed for improvement of their quality of life after treatment with roxithromycin. Patients were orally given roxithromycin 300 mg daily for 2–4 weeks. At the time of pre- and post-treatment, the dermatologists graded the severity of acne symptoms, and the patients answered questionnaires. In 123 half faces of 76 patients, 80 half faces were improved, 42 half faces were not changed, and one half face was deteriorated. The score of "symptom and feeling" and "leisure" in DLQI-J and "emotions" and "symptoms" in Skindex-29-J were significantly decreased after roxithromycin treatment. Roxithromycin has a therapeutic effect on inflammatory acne and leads to improvement of quality of life in the patients.