中西医结合防治围化疗期消化道损伤

目的：寻找化疗诱导胃肠粘膜损伤的保护方法。方法：对荷Ｈ２２腹水癌小鼠化疗前后分别给与健脾益气中药、肠生态制剂（以岐杆菌和地衣芽直菌）、中西医结合（中药和肠生态制剂联合）方法防治消化道损伤。检测胃肠膜病理,用流式细胞仪检测Ｈ２２腹水癌细胞凋亡,ＭＴＴ比色法检测杀伤作用,骨髓图片检测骨髓增生相。结果：中西医结合组较单纯化疗组对胃肠粘膜有保护作用明显增强化疗对Ｈ２２腹水癌细胞的杀伤和促进凋亡,减轻胃肠粘     

EFFECTS OF RADIX ANGE LICAE SINENSIS AND SHUANGHUANGLIAN ON A RAT MOD EL OF CHRONIC PSEUDOMONAS AERUGINOSA PNEUMONIA

ＩＮＴＲＯＤＵＣＴＩＯＮ　　Ｉｎｃｙｓｔｉｃｆｉｂｒｏｓｉｓ (ＣＦ)ｐａｔｉｅｎｔｓ,Ｐｓｅｕｄｏｍｏｎａｓａｅｒｕｇｉ ｎｏｓａ (ＰＡ)ｉｓｔｈｅｍａｊｏｒｐａｔｈｏｇｅｎｃａｕｓｉｎｇｃｈｒｏｎｉｃｌｕｎｇｉｎｆｅｃ ｔｉｏｎｗｉｔｈｉｎｃｒｅａｓｉｎｇａｇｅ (1,2 ) .Ｔｈｅｉｎｆｅｃｔｉｏｎｒｅｓｕｌｔｓｉｎａｒｅｍａｒｋａｂｌｅａｎｔｉｂｏｄｙｒｅｓｐｏｎｓｅ ,ｌｅａｄｉｎｇｔｏｆｏｒｍａｔｉｏｎｏｆｉｍ ｍｕｎｅｃｏｍｐｌｅｘｅｓｆｏｌｌｏｗｅｄｂｙｉｎｆｉｌｔｒａｔｉｏｎｏｆｐｏｌｙｍｏｒ…     

川芎嗪注射液对大鼠腹膜透析效能的影响

目的 通过动物实验观察川芎嗪对腹膜透析效能的影响,并初步探讨其作用机理。方法 采用空白及实验对照设计,将３６只雄性ＳＤ大鼠平均分为单纯腹透组、多巴胺对照组、川芎嗪常规浓度组及川芎嗪高浓度组４组,观察不同剂量川芎嗪加入腹透液对大鼠尿素氮清除率（ＣＢＵＮ）、肌酐清除率（ＣＣｒ）、尿素氮Ｄ／Ｐ值、肌酐Ｄ／Ｐ值、排液量均显著高于单纯腹透组（ｐ值均小于０．０５）,３组间两两比较差异无显著性（ｐ值均大于０．０     

黄芪灯盏花注射液对阳气虚型冠心病心率变异的影响

观察黄芪灯盏花注射液对 2 5例阳气虚型冠心病患者的心率变异性(HRV)的影响 ,并设对照组及正常人组 ,采用动态心电图含有 HRV时域分析软件进行分析。结果 :黄芪灯盏花注射液组 HRV数值明显提高 ,差异显著 (P<0 .0 5 ) ,或非常显著 (P<0 .0 1)。提示 :黄芪灯盏花注射液对冠心病患者 HRV心脏自主神经功能具有益影响。     

Risky drug practices and treatment needs of youth detained in New South Wales Juvenile Justice Centres

Demographic, drug use and criminal correlates of risky drug practices were examined among 279 detained youth in NSW Juvenile Justice Centres. Binge drinking was common, with 63% reporting the consumption of at least five drinks in a row in the 2 weeks prior to incarceration. It was associated with being older, being from an English-speaking background, regular tobacco consumption and having a current drug problem. A quarter (24%) of the sample had injected an illicit drug, over one-third (37%) of whom also reported sharing needles. Injectors were more likely to be polydrug users, regular amphetamine users and have a past history of drug treatment. While 16% of the sample indicated a need for drug treatment, only 10% were currently receiving some form of treatment, most commonly counselling. Appropriate strategies are needed among this population to address gaps in treatment provision.     

A comparison of perinatal mortality between ethnic Chinese and ethnic whites: Why the Chinese rate was lower

Objectives. To confirm the observation that has been occasionally reported in the literature that perinatal mortality rate is lower in ethnic Chinese than in ethnic whites, and to assess the reasons for this lower perinatal mortality rate.

Methods. Secondary‐analysis based on published data.

Results. This exercise demonstrates that the perinatal mortality rate was lower in ethnic Chinese than in ethnic whites. The birth weight distribution in ethnic Chinese was more favourable with reduced births at two extremes of the distribution, and the exposure to risk factors for perinatal death by their mothers was also lower.

Conclusion: Perinatal mortality rate is lower in ethnic Chinese than in ethnic whites, and the lower perinatal mortality rate in ethnic Chinese is probably caused by their favourable birth weight distribution and lower exposure to risk factors of perinatal death by their mothers.     

Examiner Differences in the Mini-Cex

Objective: The objective of this study was to analyze whether faculty ratings of residents, using the mini-CEX oral exam format, differed in stringency or were influenced by the clinical setting. It also sought to learn whether the examiners were satisfied with the format.Method: A mini-CEX encounter consisted of a single faculty member observing a resident conduct a focused history and physical examination in an inpatient, outpatient, or emergency room setting. After asking the resident for a diagnosis and treatment plan, the faculty member rated the resident and provided educational feedback. The encounters were intended to be short and occur as a routine part of the training, so each resident would be evaluated on many occasions by different faculty.Sample: Sixty-four attending physicians evaluated residents from five internal medicine training programs; data were analyzed for 355 mini-CEX encounters involving 88 residents.Results: There were not large differences among the examiners in their ratings. Moreover, there were not great differences among the ratings in terms of the training program with which the examiner was associated, the setting of the mini-CEX, or the nature of the patient. The examiners were generally satisfied with the format and their level of satisfaction was correlated with the residents' perceptions of the format.Conclusion: The mini-CEX adapts itself to a broad range of clinical situations, and these results show that it should produce roughly comparable scores over examiners and settings. This makes it a worthwhile device for evaluation at the local level.This revised version was published online in September 2005 with corrections to the Cover Date.     

Rapid molecular characterization of Hb H disease in Chinese by polymerase chain reaction

Summary We have developed a rapid method to molecularly distinguish different types of Hb H disease. The study depended on (a) most of the Hb H disease in Taiwan having an-thalassemia-1 of the Southeast Asia type (-SEA) in one allele and (b) the differences of X box of-globin gene cluster in the other allele. To detect the -SEA allele, we utilized the primers located on either side of the breakpoint to do PCR, then characterized the amplified products. For the other allele, we sequenced part of the X box, and found that bases –2803 to –2461 of the X box of – ^3.7 belonged to the X box of ₂ globin gene. In – ^4.2, the bases belonged to the X box of ₁ globin gene, whereas in ^cs it contained both X boxes of ₁ and ₂ globin genes. There was anMboII site at this region of the X box of ₂ globin gene. We utilized PCR to amplify this region and digested it with restriction enzymeMboII, then combined it with another PCR of different primer pairs to molecularly diagnose different types of Hb H disease. One hundred and one cases of Hb H disease from different families were studied: all of the cases had one allele of -SEA deletion, while the other allele showed that 52/101 were – ^3.7, 41/101 were ^cs , 7/101 were – ^4.2, and 1/101 was – ^G.Taichung. Of 52 cases of Hb H with – ^3.7, 47 were type-I deletion and five were type-II deletion.