全文获取类型
收费全文 | 461625篇 |
免费 | 33952篇 |
国内免费 | 14713篇 |
专业分类
耳鼻咽喉 | 4568篇 |
儿科学 | 17236篇 |
妇产科学 | 8730篇 |
基础医学 | 37926篇 |
口腔科学 | 7626篇 |
临床医学 | 53421篇 |
内科学 | 69915篇 |
皮肤病学 | 6566篇 |
神经病学 | 24653篇 |
特种医学 | 18325篇 |
外国民族医学 | 50篇 |
外科学 | 50512篇 |
综合类 | 65504篇 |
现状与发展 | 61篇 |
一般理论 | 27篇 |
预防医学 | 29886篇 |
眼科学 | 7862篇 |
药学 | 41876篇 |
450篇 | |
中国医学 | 46851篇 |
肿瘤学 | 18245篇 |
出版年
2024年 | 1037篇 |
2023年 | 6212篇 |
2022年 | 11303篇 |
2021年 | 21493篇 |
2020年 | 16355篇 |
2019年 | 19118篇 |
2018年 | 13823篇 |
2017年 | 14061篇 |
2016年 | 16504篇 |
2015年 | 18647篇 |
2014年 | 35810篇 |
2013年 | 33118篇 |
2012年 | 34517篇 |
2011年 | 33087篇 |
2010年 | 28161篇 |
2009年 | 26341篇 |
2008年 | 24101篇 |
2007年 | 24747篇 |
2006年 | 21202篇 |
2005年 | 15913篇 |
2004年 | 11113篇 |
2003年 | 9685篇 |
2002年 | 7421篇 |
2001年 | 6473篇 |
2000年 | 5501篇 |
1999年 | 4310篇 |
1998年 | 4192篇 |
1997年 | 3876篇 |
1996年 | 3448篇 |
1995年 | 3266篇 |
1994年 | 2967篇 |
1993年 | 2418篇 |
1992年 | 2484篇 |
1991年 | 2145篇 |
1990年 | 2022篇 |
1989年 | 1823篇 |
1988年 | 1780篇 |
1987年 | 1543篇 |
1986年 | 1286篇 |
1985年 | 2282篇 |
1984年 | 2314篇 |
1983年 | 1591篇 |
1982年 | 1792篇 |
1981年 | 1715篇 |
1980年 | 1492篇 |
1979年 | 1254篇 |
1978年 | 931篇 |
1977年 | 891篇 |
1976年 | 787篇 |
1975年 | 513篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Yang Liu Yanyan Gao Hengliang Liu Qi Chen Jinrui Ji Kailong Jia 《Arquivos brasileiros de cardiologia》2021,116(2):229
BackgroundDual antiplatelet therapy (DAPT) is the cornerstone treatment of acute myocardial infarction (AMI).ObjectiveThe present study aimed to investigate the efficacy and safety of triple antiplatelet therapy (TAPT) in elderly female patients with diabetes and ST segment elevation myocardial infarction (STEMI), who had undergone percutaneous coronary intervention (PCI).MethodsWe designed a randomized, single-blind study. Control group A (97 elderly male patients with diabetes and STEMI, whose CRUSADE scores were < 30) received aspirin, ticagrelor, and tirofiban. A total of 162 elderly female patients with diabetes and STEMI were randomly divided into two groups according to CRUSADE score. Group B (69 patients with CRUSADE score > 31) received aspirin and ticagrelor. Group C (93 patients with CRUSADE score < 30) received aspirin, ticagrelor and tirofiban. P values < 0.05 were considered statistically significant.ResultsCompared to the findings in group A, post-PCI Thrombolysis in Myocardial Infarction (TIMI) grade 3 blood flow and TIMI myocardial perfusion grade 3 were significantly less prevalent in group B (p < 0.05). When compared to groups A and C, the incidence of major adverse complications was significantly higher in group B (p < 0.05).ConclusionTAPT could effectively reduce the incidence of major complications in elderly female patients with diabetes and STEMI. However, close attention should be paid to hemorrhage in patients receiving TAPT. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0) 相似文献
102.
103.
104.
应用拷贝数变异测序(copy number variation sequencing,CNV-seq)技术鉴别来源不明的胎儿标记染色体,明确其遗传物质的来源,并探讨此技术在产前诊断中的应用价值。讨论Pallister-Killian综合征(Pallister-Killian syndrome,PKS)的临床特征及遗传学特点,提高对此类罕见染色体疾病的认识。该病例因在妊娠中期超声发现胎儿异常而行羊水穿刺进行CNV-Seq检测,同时分析胎儿和父母的核型。羊水CNV-Seq结果示该样本12号染色体p13.33-p11.1处检测到拷贝数为3.5、片段大小为34.70 Mb的嵌合重复区域;羊水染色体核型结果为47,XY,+i(12)(p10)[58]/46,XX[42],综合上述结果考虑为PKS。通过结合超声结果,综合应用染色体G显带核型分析和CNV-seq技术能准确确认染色体异常片段来源,在产前有效诊断PKS患者。 相似文献
105.
《Vaccine》2020,38(45):7118-7128
IntroductionToward the Global Vaccine Action Plan 2020 goal, almost 90% of countries have established a National Immunization Technical Advisory Group (NITAG). However, little is known about NITAG's contributions to governance.MethodsIn 2017–2018, a two-step, qualitative retrospective study was conducted. Jordan (JO), Argentina (AR), and South Africa (SA) were selected owing to government-financed NITAGs from middle-income countries (MICs), geographic diversity, and a vaccine introduction with NITAG support. Country case studies were developed, collecting data through desk review and face-to-face key informant interviews (KIIs) from Ministry of Health (MoH) and NITAG. Case studies were analyzed together, to assess governance applying the European Observatory on Health Systems and Policies framework focusing on transparency, accountability, participation, integrity, and policy capacity (TAPIC).ResultsDocument review and 53 KII (22 AR, 20 SA, 11 JO) showed NITAGs played a pivotal role as advisors promoting a culture of evidence-informed policies. NITAGs strengthened governance, although practices varied among countries. Meetings were conducted behind-closed-doors, participation restricted to members, only in one country agendas, and recommendations were public (AR). To increase participation, policy capacity, and transparency, countries considered adding experts in communications, advocacy, and economics. AR and SA contemplated including community members. NITAGs functioned autonomously from the government, with no established internal or external monitoring or supervision. NITAG meeting minutes allowed the review of integrity, adherence to terms of reference, standard operating procedures, and conflict of interest (CoI). For the most part, NITAGs abided by their mandates. Significant issues were related to the level of MoH support and oversight of CoI declaration and documentation.ConclusionsSystematically implementing governance approaches could improve processes, better tailor policies, and implementation. The long-term survival and resilience of NITAGs in these countries showed they play a significant role in strengthening governance. Lessons learned could be useful to those promoting country-driven evidence-informed decision-making. 相似文献
106.
皮肤损伤后的异常愈合会导致病理性瘢痕的产生。病理性瘢痕的出现不仅影响美观,严重时还会造成心理和生理功能障碍。病理性瘢痕的机制研究对于瘢痕治疗有极为重要的意义。其中,动物瘢痕模型是目前研究病理性瘢痕的重要模型手段之一。理想的动物瘢痕模型应该在组织学、细胞学等层面尽可能接近于人类的病理性瘢痕。该文分别从传统技术动物瘢痕中的啮齿类动物模型、兔耳模型和猪模型,以及新技术动物瘢痕模型这两个方面,结合近年来在瘢痕领域应用较多的研究,进行了相应系统的阐述。 相似文献
107.
108.
目的 探讨模拟诊疗在留学生心血管内科实习带教中的应用效果。方法 将35名留学生随机编号,分成试验组和对照组。试验组18名学生分成3组(每组6名)进行模拟诊疗教学,对照组17名学生进行常规实习。通过填写评价单和相关的临床能力测试对两组教学效果进行评价。选用SPSS 19.0软件进行t检验。结果 参与模拟诊疗教学的留学生均希望在各科实习中多采用此方法。在临床能力测试方面,试验组学生在病史采集[(22.16±2.17)vs.(20.33±2.03)]、体格检查[(23.05±1.79)vs.(19.78±2.05)]及回答问题[(23.50±1.47)vs.(19.56±1.92)]方面均优于对照组,差异有统计学意义(P<0.05)。但是在病历书写方面,两组差异无统计学意义(P>0.05)。结论 利用高仿真的模拟诊疗教学手段,弥补了留学生在实习期间不能充分接触患者的缺陷,有助于提高其临床操作技能、增强医患沟通能力等医学职业素养。 相似文献
109.
《Sleep medicine》2020
Transcranial magnetic stimulation (TMS) may offer a reliable means to characterize significant pathophysiologic and neurochemical aspects of restless legs syndrome (RLS). Namely, TMS has revealed specific patterns of changes in cortical excitability and plasticity, in particular dysfunctional inhibitory mechanisms and sensorimotor integration, which are thought to be part of the pathophysiological mechanisms of RLS rather than reflect a non-specific consequence of sleep architecture alteration.If delivered repetitively, TMS is able to transiently modulate the neural activity of the stimulated and connected areas. Some studies have begun to therapeutically use repetitive TMS (rTMS) to improve sensory and motor disturbances in RLS. High-frequency rTMS applied over the primary motor cortex or the supplementary motor cortex, as well as low-frequency rTMS over the primary somatosensory cortex, seem to have transient beneficial effects. However, further studies with larger patient samples, repeated sessions, an optimized rTMS setup, and clinical follow-up are needed in order to corroborate preliminary results.Thus, we performed a systematic search of all the studies that have used TMS and rTMS techniques in patients with RLS. 相似文献
110.