大鼠模拟经前期综合征(PMS)肝气逆证动情周期血清激素水平的测定基金项目:国家中医药管理局资助课题 No:972035

本实验通过对雌性正常青年大鼠(未孕)和经脉冲电剌激5天造模大鼠血清激素的测定,结果发现:未孕正常大鼠血清中泌乳素(PRL)、雌二醇(E2)、孕酮(P)在动情期的前、中、后三期变化很显著(P<0.001);造模未孕大鼠三种激素除孕酮在中后期变化不显著、雌二醇在前中期较显著(P<0.01)外,其余均很显著(P<0.001),且三种激素与正常未孕相应期比除孕酮的中期变化不显著外,其余均变化很显著(P<0.001).     

男性不育症患者血清TNF-α、T、FSH、PRL检测的临床意义

目的：探讨男性不育症患者血清TNF-α、T、FSH、PRL水平的变化及临床意义。方法：应用放射免疫分析对36例男性不育症患者进行了血清TNF-α、T、FSH、PRL检测,并与35例男性正常人作比较。结果：男性不育症患者血清T水平非常显著地低于男性正常人组（P〈0.01）,而TNFα-、FSH、PRL水平又非常显著地高于男性正常人组（P〈0.01）,血清TNF-α水平与T水平呈负相关（r=-0.5184,P〈0.01）,与FSH、PRL水平呈正相关（r=0.6184、0.5925,P〈0.01）。结论：检测男性不育症患者血清TNF-α、T、FSH、PRL水平的变化对诊断、预后判断及治疗均有较大的临床价值。     

Neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher T3 transfer by milk after nicotine withdraw

Maternal nicotine exposure leads to neonatal hypothyroidism that can be returned to euthyroidism after nicotine withdrawal. Here, we examined the transfer of iodine through milk, deiodinase activities (D1 and D2), and serum T3, T4 and TSH in rat offspring after maternal exposure to nicotine. One day after birth, a minipump was implanted to dams releasing nicotine (NIC), 6 mg/kg/day for 13 days or vehicle saline. Animals were killed at the day 15 and 21 of lactation. At day 15, NIC-treated dams showed decreased T4 and mammary 2 h-radioiodine uptake (RAIU) and increase of TSH, thyroid 2 h-RAIU, liver D1 and mammary D2. At the cessation of NIC-exposure, pups displayed decreased T3, T4 and thyroid 2 h-RAIU and increased TSH. At weaning (21-postnatal day), NIC-treated dams recovered their T4 and TSH, but increased deiodinase level in the liver and mammary gland. Milk T3 content in NIC-treated dams was higher at both day 15 and 21, and thyroid function was recovered at the day 21. Thus, thyroid function was affected by nicotine in both mothers and pups, suggesting a primary hypothyroidism. After nicotine withdrawal, pups recovered thyroid function probably due to the increased lactational transfer of T3 in relation with increased mammary gland deiodinase activities.     

老年人群血清LH、PRL及睾酮变化规律的研究

应用RIA方法．检测627例血清睾酮（T）、促黄体生成素（LH）和泌乳素（PRL）水平．探讨各激素的增龄性变比。结果表明：血清T水平对照组为32．07±14．25nmol／L其它各组随增龄呈进行性降低．且与对照组相比存在显著差异（P＜005）：血清LH水平是随龄增高趋势．且与T变比呈显著负相关（r=－0．21，P＜0．01）。血清PRL水平亦呈现随龄增高趋势。PRL与T（r=－0．12．P＜0.05）、PRL与LH（r=0．11．P＜0．05）呈微弱相关关系。上述结果提示．在男性衰老过程中．T水平逐渐降低．对LH负反馈抑制作用减弱，而引致LH分泌增高．血清PRL对性腺轴激素水平有影响．但其具体作用及作用方式有待进一步研究。     

产后不宜哺乳产妇回乳时机探讨

目的探讨产后回乳的最佳时机。方法将2004年11月-2005年6月自然分娩不宜用母乳喂养的产妇152例,按住院号的单双数分为观察组88例,于产后立即给予维生素B6200 mg口服,3次/d,每日煎服200 g麦芽汁,而对照组64例产妇于产后72 h同法口服维生素B6及麦芽汁。结果观察组产妇回乳效果比对照组产妇好,两者比较有显著性差异(P<0.001)。结论对于产后不宜母乳喂养的产妇应及早采取回乳措施,最好于产后立即进行,以便取得较好的回乳效果。     

产妇乳汁PRL分泌影响因素的探讨

报道140例产后36～48、72～96小时的产妇乳汁中PRL 测定结果,表明乳汁中PRL 水平随产后时间的延长而逐渐下降,PRL 水平与泌乳量呈正相关。产后投子宫收缩剂麦角组的产妇乳汁中PRL 值低于投催产素组产妇乳汁中的PRL 值;分娩女婴的产妇乳汁中PRL 值高于分娩男婴产妇乳汁中PRL 值。但不同年龄、不同分娩方式及从事脑力或体力劳动的产妇乳汁中PRL 值未见显著差异。     

Effects of exogenous melatonin on pituitary hormones in humans

The effects of melatonin on physiological function remain unclear, although the therapeutic potential of melatonin is being increasingly recognized. The aim of the present study is to investigate the effects of exogenous melatonin on the spontaneous release of pituitary hormone in humans. A double blind placebo‐controlled protocol was designed to examine 12 adult healthy volunteers and 12 sleep disorder patients who have been treating with low doses of melatonin for 1 year. Either exogenous melatonin or placebo of 1 mg was given at 09:00 hours, followed by the collection of blood samples every 20 min for 4 h. Each blood sample was examined for levels of serum melatonin, PRL, LH, FSH, GH and TSH. LH levels were higher in sleep disorder patients compared with the healthy volunteers. In other pituitary hormones, there were no significant difference between healthy adults and sleep disorder patients. In all subjects, PRL levels were stimulated by acute administration of 1 mg of exogenous melatonin, while the levels of other pituitary hormones were not affected. These results suggested that exogenous melatonin can affect the spontaneous release of LH and PRL in humans. In addition, we demonstrated that 1‐year oral melatonin treatment did not affect the responses to the acute administration of melatonin.     

子宫内膜分泌不良不孕妇女内膜胞浆女性激素受体和相关血清激素水平关系探讨

本文对内膜分泌不良妇女子宫内膜胞浆雌、孕激素受体含量变化及血清雌二醇、孕酮、促卵泡成热激素及垂体泌乳素水平进行了分析讨沦,了解子宫内膜发育与雌、孕激素受体及血清有关激素之间的关系。结果表明,内膜分泌不良组与对照组比较,雌激素受体含量明显降低(P<0.005),孕激素受体含量同时降低(P<0.05)。提示不孕妇女子宫内膜分泌不良,可能是由于组织胞浆雌、孕激素受休含量降低,使其对相应激素的反应性下降所致。建议对这类患者的治疗方案应从激素水平及受体含量两方面进行考虑。