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991.
重组抗原的IgM捕捉ELISA在肾综合征出血热诊断中的应用 总被引:3,自引:2,他引:1
用原核表达的汉坦病毒76118株核蛋白为夹心抗原,组合抗人μ链多克隆抗体和酶标抗汉坦病毒单克隆抗体,建立了IgM捕捉法ELISA,用以检测610份疑似患者血清,并与免疫荧光法(IFA)相比较。结果本方法与IFA的阳性符合率9410%、阴性符合率9283%、总符合率9361%,检出率在发病5日内明显高于IFA,6至30日无区别,30天后开始下降,检出病例的月分布与发病规律相符。表明重组核蛋白抗原的IgM捕捉ELISA能够准确早期诊断HFRS。 相似文献
992.
993.
994.
对31 例Du 患者及31 例慢性胃炎患者进行HP 检测及血清胃泌素测定,并对其中23 例HP阳性Du 患者抗HP 治疗后的血清胃泌素及HP 进行测定。结果显示HP 检出率Du 组为74 .19 % (23/31) ,较慢性胃炎组48 .39 % (15/31) 高( P< 0 .05) ;DuHP 阳性组的血清胃泌素较DuHP 阴性组、慢性胃炎HP 阳性组及慢性胃炎HP 阴性组明显增高( P 均< 0 .05) ,而DuHP 阴性组的血清胃泌素与慢性胃炎HP 阳性组及慢性胃炎HP 阴性组比较差异无显著性( P> 0 .05) ,23 例DuHP 阳性者抗HP 治疗后,HP转阴者的血清胃泌素较治疗前明显下降(P< 0 .05) ,HP 未转阴者的血清胃泌素前后差异无显著性( P>0.5) 。提示Du 血清胃泌素与幽门螺杆菌感染有一定相关性。 相似文献
995.
Lee CT Kuo BI Chen CY Chang FY Lee SD 《European journal of clinical pharmacology》1999,54(11):817-820
Objective: To determine which demographic factors may influence serum gastrin and pepsinogen I (PGI) levels in duodenal ulcer patients
undergoing omeprazole treatment.
Methods: We conducted an outpatient-based prospective study in the Veterans General Hospital, Taipei, to investigate the pharmacological
effects on patients with duodenal ulcers receiving omeprazole treatment for 4 weeks. Sixty-eight patients (61 males/7 females,
aged 25–73 years) with endoscopically confirmed duodenal ulcer were included. Gastrin and pepsinogen I levels were measured
before and after treatment. Demographic factors including age, sex, smoking, ulcer healing and antral Helicobacter pylori colonization/clearance were analyzed, in order to measure their probable influences on serum gastrin and pepsinogen I levels.
Results: Ulcer healing was seen in 92.6% of patients while 48 (70.6%) antral clearances were seen in 66 H. pylori colonized patients at the end of trial. Omeprazole monotherapy led to a marked elevation of serum gastrin (85.8 pg · ml−1, SD 32.0 pg · ml−1 vs 133.9 pg · ml−1, SD 71.6 pg · ml−1, P < 0.01), and pepsinogen I (111.0 ng · ml−1, SD 36.7 ng · ml−1 vs 253.6 ng · ml−1, SD 64.8 ng · ml−1, P < 0.01) levels when measured on day 29. Only patients showing antral H. pylori clearance exhibited an influence on the magnitude of pepsinogen I elevation following omeprazole monotherapy (143.9%, SD
67.3% vs 78.6%, SD 51.2%, P < 0.01). Moreover, the sensitivity and specificity of serum pepsinogen I variations were plotted on a receiving operating
characteristic (ROC) curve. The 140% increased pepsinogen I level yielded a maximum accuracy of 80% specificity or 50% sensitivity
to predict antral H. pylori clearance.
Conclusion: Antral H. pylori clearance is at least partially responsible for the omeprzaole-induced hyperpepsinogenemia I. The magnitude of hyperpepsinogenemia
I probably provides a non-invasive alternative for predicting H. pylori clearance.
Received: 22 August 1996 / Accepted in revised form: 1 October 1998 相似文献
996.
Effective treatment of acute hyperkalaemia in childhood by short-term infusion of salbutamol 总被引:1,自引:0,他引:1
M. J. Kemper E. Harps H. H. Hellwege D. E. Müller-Wiefel 《European journal of pediatrics》1996,155(6):495-497
Hyperkalaemia is a lifethreatening emergency and infusion of glucose with insulin has so far been regarded as the standard treatment of choice. Recently the -2 stimulatory drug salbutamol has been shown to be an effective agent to treat hyperkalaemia by inducing a shift of potassium into the intracellular compartment. We treated 15 children aged 0.1–14 (mean 5.2) years suffering from acute hyperkalaemia (mean level 6.6±0.54, range 5.9–7.7 mmol/l) with a single infusion of salbutamol (5 g/kg over 15 min). Serum potassium concentrations decreased significantly within 30 min to levels of 5.74±0.53 and 4.92±0.53 mmol/l after 120 min (P<0.001, respectively). No side-effects occurred other than a slight increase in heart rate in 3 patients.Conclusion A single intravenous infusion of salbutamol at a dose of 5 g/kg is a highly effective treatment for hyperkalaemia with minimal clinical side-effects. The effect lasts for at least 120 min and may reverse hyperkalaemia in some patients without further interventions so that salbutamol seems justified as the first choice treatment for this condition in childhood. 相似文献
997.
Bilateral striatal necrosis in children without damage elsewhere in the brain can present as an acute neurological disorder
or as a progressive disorder. Three children of 6, 7 and 12 years age developed dystonic posture of limbs without any cranial
nerve involvement or alteration of sensorium soon after recovery from acute high grade febrile illness of 3–4 days duration.
Computerized tomographic scan of head showed bilateral necrosis of basal ganglia. We think that these patients probably constitute
a clinically and radiologically distinct subgroup of disorder that prouce bilateral striatal necrosis in children. The cause
of the syndrome is unknown. 相似文献
998.
Chaudhary S 《Indian journal of pediatrics》1996,63(4):433-436
Otitis media is a common pediatric problem. It is well established that over half of infants and children with acute otitis
media may have spontaneous recovery. Since it is difficult to predict the course (self-limited versus serious disease) all
the children with acute suppurative otitis media need to be treated with antibiotics. Amoxicillin is still the initial antibiotic
of choice. There are several alternate antibiotics available with activity against beta-lactamase positive bacteria. These
agents have no advantage over amoxicillin in infections due to penicillin resistant pneumococci. Recent use of beta-lactam
antibiotics and/or attendance in a day care where there is frequent use of antibiotics are predisposing factors for penicillin
resistant pneumococcal infection. In such cases after tympanocentesis, higher dose of amoxicillin, clindamycin or intramuscular
ceftriaxone should be considered. Secretory otitis media does not need to be treated with antibiotics unless the patient is
in high risk group. Prophylactic use of antibiotics should be actively discouraged. Influenza and pneumococcal vaccination
(2 years or older) should be encouraged in children with recurrent episodes of acute otitis media. Breast feeding should be
encouraged. 相似文献
999.
E. Tasdemiroglu E. Bagatur I. Ayan E. Darendeliler R. A. Patchell 《Acta neurochirurgica》1996,138(11):1261-1266
Summary Five cases of primary spinal column sarcomas are presented. Sarcomas primarily originating from paravertebral soft tissues were excluded. Patients' age ranged from 1 to 14 years (mean 8.4 years). The male: female ratio was 23. Two patients had Ewing's sarcoma (ES) originating from L5-S1 and L4-5 pedicles, respectively; two patients had mesenchymal chondrosarcoma (MCS) originating from L1-2 pedicles and L5 body, respectively; and one patient had osteogenic sarcoma (OS) of C4 body. All patients clinically presented with pain and progressive weakness of the extremities. The time that elapsed between the onset of symptoms and diagnoses ranged from one to five months. All cases were treated with chemotherapy, radiotherapy and subtotal tumour resection with spinal canal decompression. Two cases received posterior spinal fusion operations. Three patients were alive 10 to 98 months following diagnosis. Only the case with ES of L5-S1 pedicles was in complete remission and off therapy at the 98th postoperative month. The two MCS cases were in partial remission, and were receiving chemoterapy at the time of analysis. These tumours caused similar clinical findings and prognoses, and required combined treatment, which consisted of surgery, radiotherapy and chemotherapy; histologically three different types of malignant tumours are presented in the same category. We preferred surgical decompression and stabilization procedures especially for neurologically symptomatic patients, even if they had extensive tumours with high grades. By spinal canal decompression and stabilisation, we did not intend to cure the disease; however, we intended to provide neurological improvement, spinal stabilisation, improved quality of life, early mobilisation of the patient, and cytoreduction by means of surgical tumour ablation, which could render the chemotherapy more effective. 相似文献
1000.
Fabrizio Tagliavini Giorgio Giaccone Orso Bugiani Blas Frangione 《Acta neuropathologica》1993,85(3):267-271
Summary Here ditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA-D) is characterized clinically by recurrent strokes and pathologically by deposition of amyloid (A) in cerebral vessel walls and, to a lesser extent, in the neuropil. Distinct from Alzheimer's disease, amyloid formation in HCHWA-D is not associated with neurofibrillary changes. Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of A in the neurodegencrative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. The study showed that amyloid deposits in the vessel walls and in the neuropil were surrounded by abnormal ubiquitinated neurites, suggesting that A deposition induces neuritic changes.Supported by the Italian Ministry of Health. Department of Social Services, and by N.I.H. Grants AG05891 and AG08721 (to B.F.) 相似文献