Test meal intake in obese binge eaters in relation to mood and gender

OBJECTIVE: We assessed test meal intake in men and women with and without binge eating disorder (BED) in relation to mood score (Zung scale). METHODS: Eighty-five overweight subjects (24 males and 61 females) participated; 30 subjects with BED and 55 without BED. Following an 8-hr fast, subjects consumed a liquid test meal until extremely full. RESULTS: BED subjects consumed significantly more (p =.009) of the test meal (1,032 g +/- 429) than the non-binge eaters (737 g +/- 399). The men ingested more than the women (p =.002). BED subjects also had higher depression scores (p =.01), without differing by gender. However, depression scores were unrelated to test meal intakes (r = -.01). DISCUSSION: The larger meal intakes of the BED group may be due to the larger stomach capacity previously found in both bulimics and obese subjects. The findings also support the premise that BED, listed in the DSM-IV appendix for further study, is found in a distinct subgroup of overweight individuals.     

Risk factor profile for atherosclerosis among young adults in Israel--results of a large-scale survey from the young adult periodic examinations in Israel (YAPEIS) database

Assessing the prevalence of relevant risk factors among young adults is a critical step in the process of preventing atherosclerotic cardiovascular diseases (ASCVD) later in life. The Israel Defense Force Periodic Health Examination Center performs a routine check-up for subjects aged 25–45 years. Medical history, physical examination notes, laboratory results and ECG tracings are recorded, computerized and processed to form the Young Adults Periodic Examinations in Israel (YAPEIS) database. Data representing 31,640 subjects (27,769 males and 3871 females) examined between the years 1991–1999 were analyzed. The prevalence of documented risk factors for ASCVD were evaluated. The results of all parameters were graded categorically as low, moderate or high and the Framingham risk score was calculated. Fifty-one percent of the study participants were found to be overweight (body mass index 25 kg/m²), 8.5% had high systolic blood pressure and 14.6% had high diastolic blood pressure. The prevalence of hypercholesterolemia and hyperglycemia was found to be 44.7 and 9.7%, respectively. Thirty-two percent of the subjects smoked cigarettes, and 76.7% reported not performing any routine physical activity. Furthermore, 31.8% had a Framingham score indicating a greater than 5% risk for developing a coronary event within the next 10 years. As expected, the prevalence of these risk factors increased with age and were found to be less frequent among females. Thus we conclude that many young Israeli adults hold significant risk factors for future ASCVD. Many of these risk factors are modifiable, and risk behavior is often amenable to alteration. Awareness to the high prevalence of risk factors among young adults should spark vigorous health-promotion programs as well as screening, education, and interventional measures aimed at altering the expected outcome of future ASCVD.     

中国成人家庭内部食物分配及影响因素

目的 :　研究家庭成员的性别、年龄、职业、个人收入、是否户主等特征对食物分配的影响。方法 :　利用中美合作课题“中国健康与营养调查”1 993年的资料 ,应用多元 Logistic回归方法进行分析。本研究用“偏差分数”来表示食物分配情况。结果及结论 :　男性比女性更有可能分得较多的食物 ;45岁以上中老年人会比 1 8～ 44岁年龄组人群获得更多的食物分配 ;干部和服务行业人群在家庭内部食物分配中更易受到偏向 ,农村地区工人职业人群会得到较多的食物分配 ;经济收入较高的家庭成员在食物分配中更易受到偏爱 ;家庭中户主分得的食物所占全家的比例会比其他家庭成员要高。     

氧化苦参碱对大鼠局灶性脑缺血再灌注损伤保护作用的中枢机制

目的：探讨氧化苦参碱（OMT）对大鼠局灶性脑缺血再灌注损伤的作用及其中枢机制。方法：采用结扎大脑中动脉的方法制备大鼠局灶性脑缺血再灌注模型。外周给药大鼠随机分为假手术组、脑缺血再灌注模型组、路路通组（LLT，31.25 mg•kg^-1）及OMT 35、70和105 mg•kg^-1 腹腔注射给药组；脑室给药大鼠随机分为假手术组、脑缺血再灌注模型组、LLT 0.15 mg•kg^-1组及OMT 0.35 mg•kg^-1脑室注射给药组。以神经学评分及脑梗塞面积为指标观察OMT对大鼠局灶性脑缺血再灌注性损伤的保护作用，同时检测OMT脑室注射给药大鼠血清NO含量。结果：与脑缺血再灌注模型组比较，腹腔注射OMT 105 mg•kg^-1组神经学评分明显降低（P<0.05），OMT 70和105 mg•kg^-1组脑梗塞面积缩小（P<0.05）；与脑缺血再灌注模型组比较， OMT 0.35 mg•kg^-1脑室注射给药组大鼠脑梗塞面积缩小（P<0.05），血清NO含量明显降低（P<0.05）。结论：脑室注射OMT对局灶性脑缺血再灌注大鼠的脑损伤具有明显的保护作用，中枢作用可能为其机制之一。     

"创伤评分系统"软件的研制

目的：研制集多种院前和院内评分为一体的简捷方便的评分工具软件系统。方法：将创伤评分各指标参数进行比较归类分解，编制评分系统功能与流程，采用Delphi语言进行编程。结果：成功编制出“创伤评分系统”软件，该软件功能主要包括：新建、查询、打印、资料备份与恢复、字典维护等功能；可实现步步提示查询AIS评分和诊断、同时计算10种常用创伤评分、数据资料随意组合查询、结果导出和打印等。结论：该软件资料录入简捷方便，计算简单准确，资料查询筛选方便为创伤临床医师提供了一种科学、便捷、高效的工具．     

小儿急性胰腺炎病情严重度评分的临床应用

目的 探讨小儿急性胰腺炎评分系统在病情严重度判定中的临床应用价值.方法 回顾分析2002年1月～2006年8月间本院收治的49例小儿急性胰腺炎(AP)病例,分析比较Ranson、APACHEⅡ及小儿急性胰腺炎评分(John评分)系统对小儿急性胰腺炎病情严重度评判的灵敏度、特异度、似然比及接收者工作特征(ROC)曲线下面积(AUC)等指标,检验各评分系统对小儿AP病情严重度评判的价值.结果 49例中,发生胰腺坏死/假性囊肿/脓肿,脏器功能障碍等严重并发症的小儿SAP重症急性胰腺炎(SAP)7例,轻症急性胰腺炎(MAP)42例.SAP组与MAP组间,3种评分系统的分值分别为(1.12±0.29)与(0.93±0.22),(3.39±0.73)与(2.85±0.68),(3.07±0.45)与(1.12±0.27),仅John评分分值的组间差异有统计学意义(t=15.1974,P=0.0000).3种评分系统对小儿SAP评判的灵敏度分别为28.57%、42.86%、85.71%,John评分高于前二者,特异度分别为88.10%、85.71%、83.33%.3种评分系统评判小儿SAP的AUC值分别为0.54、0.59及0.90,John评分的AUC值明显高于前二者,差异有显著性意义(P=0.0083、0.0112).结论 与Ranson及A-PACHEⅡ评分比较,John评分对小儿AP病情严重度和预后的评判价值较大.     

SIRS评分对ICU鲍氏不动杆菌感染患者预后评估的研究

目的 评价SIRS评分对ICU危重症患者感染鲍氏不动杆菌预后的意义.方法 回顾性分析ICU 70例鲍氏不动杆菌感染的患者临床资料,研究其预后与SIRS评分的关系.结果 70例患者中,存活51例,占72.9％,死亡19例,死亡率为27.1％；在死亡的患者当中SIRS评分高的死亡率也高,差异有统计学意义(P＜0.05).结论对于鲍氏不动杆菌感染的ICU患者,SIRS评分分值高可能预示预后不良.     

不同药物穴位注射治疗急性缺血性脑卒中的临床研究

目的:观察不同药物穴位注射治疗急性缺血性脑卒中的临床疗效差异。方法:将90例急性缺血性脑卒中患者随机分腺苷钴胺组、脑苷肌肽组和对照组,每组30例。腺苷钴胺组及脑苷肌肽组分别采用腺苷钴胺及脑苷肌肽穴位注射配合常规治疗及康复训练治疗,对照组采用常规治疗及康复训练治疗,共治疗2周。分别于治疗前后进行临床神经功能缺损评分、日常生活能力评分及临床疗效评价。结果:治疗后各组患者临床神经功能缺损评分、日常生活能力评分均较治疗前改善(P0.05)。治疗后临床神经功能缺损评分和临床疗效组间比较,腺苷钴胺组及脑苷肌肽组均优于对照组(P0.05),腺苷钴胺组及脑苷肌肽组比较差异无统计学意义(P0.05)。治疗后日常生活能力评分组间比较,腺苷钴胺组及脑苷肌肽组均优于对照组(P0.05),腺苷钴胺组优于脑苷肌肽组(P0.05)。结论:在常规治疗及康复训练基础上使用不同药物穴位注射治疗急性缺血性脑卒中,可明显改善患者的生活质量,提高临床疗效,腺苷钴胺疗效更佳。     

Pain score assessment in babies undergoing laser treatment for retinopathy of prematurity under sub-tenon anaesthesia

Purpose To assess the tolerability and outcomes of laser treatment for retinopathy of prematurity (ROP) under sub-tenon anaesthetic with oral or rectal sedation using a reliable, multidimensional, and internationally accepted tool for assessment of neonatal pain.Methods Sixty-two babies have had ROP laser treatment in our neonatal unit in the 7-year interval between 1 March 2005 and 28 February 2012; 44% (27 of the 62) were performed using sub-tenon anaesthesia. Pain scores were routinely assessed using the Neonatal Pain Agitation and Sedation Scale (N-PASS) every 10 min during laser treatment. The outcome and requirement for re-treatment in this group was compared with that in the intravenous sedation group.Results Pain scores were available in 19 of the 27 babies treated under sub-tenon anaesthesia. The mean pain score during treatment was 2.7 (SD±1.7, range 0.5–6.2). There was no statistically significant correlation between the mean pain score and duration of treatment (Spearman correlation coefficient (ρ) = 0.31; P = 0.09), number of laser burns (ρ = 0.32; P = 0.09), or post-menstrual age of the baby at the time of treatment (ρ = 0.38; P = 0.052). Treatments performed under sub-tenon anaesthesia were as successful as those performed under intravenous sedation. The mean pain scores during laser treatment under sub-tenon anaesthesia in our study were lower than those previously reported during ROP screening or heel-stick procedure.Conclusion Our study demonstrated that sub-tenon anaesthesia with oral or rectal sedation provides sufficient pain control for laser treatment for ROP without the need or risks of intravenous sedation and intubation.