组合靶基因自动检测仪应用软件的设计

目的：研制与开发组合靶基因自动检测仪应用软件。方法：应用VB6．0编程语言及Access 97数据库实现压电石英谐振频率的实时检测与分析。结果：实现了组合靶基因自动检测仪压电石英谐振频率的实时检测。数据分析，结果保存与数据转换等。结论：组合靶基因自动检测仪应用软件是一类可实时检测与分析压电石英谐振频率的新型实用性软件，可广泛应用于压电石英谐振频率的检测。     

Alternative graphical representations of genotypes in a pedigree

Three representations of the conditional independences due toMendelian segregation of genes in a pedigree are proposed. Thecomputational costs of performing calculations using the techniqueof peeling with each of these representations is compared byconsidering the weights of triangulations of the graph producedby each representation.     

重组毕赤酵母表达期菌体浓度的软测量模型

建立了用于在线估计高密度重组毕赤酵母培养过程中处于表达阶段的菌体密度软测量模型。分别对比了基于遗传算法（GA）的动力学软测量模型以及基于人工神经网络（ANN）的软测量模型，并对神经网络软测量模型的拓扑结构以及训练参数进行了初步探讨。当采用基于遗传算法（GA）的动力学模型，模型拟舍值的最大误差为7．63％；在采用神经网络软测量技术时，选取合适的模型结构和输入参数，最大误差为3．12％，而且软测量模型可以很好地反映菌体浓度实时变化趋势。该研究结果表明，在酵母细胞的高密度培养过程中采用基于神经网络的软测量模型具有较高的准确度，可以较好地实时反映发酵过程中菌体浓度的变化。     

Simulating realistic zero loop pedigrees using a bipartite Prufer code and graphical modelling.

Graph algorithms previously developed by the authors are adapted to simulate pedigrees similar to those used in genetic linkage studies which associate disease phenotypes with specific genomic locations. Pedigrees are chosen uniformly at random from the set of those with specified numbers of individuals and matings and which contain no loops. Summary statistics from pedigrees generated in this way can be used to check real pedigrees for anomalies due to biased sampling or phenotypic effects on the pedigree structure.     

How to Optimize Radiological Images Captured from Digital Cameras, Using the Adobe Photoshop 6.0 Program

Over the past decade, the technology that permits images to be digitized and the reduction in the cost of digital equipment allows quick digital transfer of any conventional radiological film. Images then can be transferred to a personal computer, and several software programs are available that can manipulate their digital appearance. In this article, the fundamentals of digital imaging are discussed, as well as the wide variety of optional adjustments that the Adobe Photoshop 6.0 (Adobe Systems, San Jose, CA) program can offer to present radiological images with satisfactory digital imaging quality.     

Methodology used for "software for automated linkage in Italy" (SALI)

Linkage of epidemiological registries can provide cost-effective information on the associations between different diseases or exposures in the population under study and on completeness of surveillance system databases. We describe the program SALI (software for automated linkage in Italy) aimed at matching individual records from medium-sized registries (in the order of 100,000 records), where the desired outcome is to miss as few links as possible and, because of low link-likelihood (< 1%), a manual revision of matched pairs is feasible. SALI, developed in CA-Clipper language, uses registry files in dBase format. It requires only name, surname, and date of birth as key fields, and it allows for spelling errors in Italian or other Latin languages through a specific algorithm. Furthermore, a double-blind procedure ensures data confidentiality. The main linkage procedure is based on four stages, two automatic ones, and two where the operator can decide through specific windows whether to accept stage-selected matches. SALI takes into account possible errors in key fields thus reducing false negatives. It was used to solve the problem of linkage between AIDS and cancer registries in Italy. It can be used with every IBM-compatible computer system, assuring uniquely high portability.     

基因组序列CGR图形表示的多重分形分析

为了更好地描述基因组序列CGR(chaos-game representation)图形的分形特征,引入多重分形理论进行分析。通过研究3种概率集对标度不变性范围的影响,选取出标度不变性最好的概率集,计算光滑的广义维数谱和多重分形谱。结果表明:以相对概率组成概率集时标度不变性最好,而且标度不变性随尺度变化可被分为3个不同的区域,这反映了基因组序列不同长度的序列片段有不同的分布规律。可见,多重分形方法可以用于描述基因组序列CGR图形的分形特征。     

基于PACS的MRI影像多媒体教学与报告系统的研究

目的：开发基于医院影像归档和通讯系统（picture archiving and communication system，PACS）环境的MRI（磁共振显像）影像多媒体教学与报告系统。方法：医院PACS系统符合DICOM3.0标准，采用1000M光纤主干网，100M交换到桌面；在临床医生浏览工作站安装多媒体教学系统，在诊断工作站安装教学系统与报告系统；科学内容按部位分类，以树枝模式管理。教学字资料来源于具有一定权威的教科书、专及期刊。图像资料来源于各部位经病理及临床证实的病例，直接从PACS系统提取，经标注说明后，以件形式存放于PACS图像服务器硬盘。结果：MRI辅助影响教学系统能够实时调阅最合适病种的MRI征象、临床特点、病理、鉴别诊断、典型图像及注释、正常断面解剖等，供教学、诊断和报告参考。结论：PACS环境下MRI辅助影像学系统，能满足临床医生和低年资影像诊断医生对MRI影像知识进一步继续医学教育的需求，能为影像诊断医生提供教学及科研工具，提高MR室工作质量和工作效率。     

基于PDA的嵌入式ECG监护分析仪

目的为了方便快捷地实时监测心律失常,设计一种基于PDA的嵌入式ECG监护分析仪。方法仪器功能包括低功耗MSP430系列单片机控制心电信号的采集、放大、滤波、转换和在PDA上实时显示、存储和分析,并实现心电数据的远程传输。对仪器工作原理进行分析,把监护分析仪总体结构划分为子模块,并具体介绍各子模块的功能与实现。结果与结论与医院现有的三导全自动心电图机、Holter动态心电图机进行对照,本监护分析仪携带方便、操作简单、接收的心电信号无失真,连续工作时间大于20h等。各高频干扰信号对ECG信号无影响;软件可对心电信号进行实时显示,可连续记录15h的原始心电数据。     

基于中医诊疗指南的冠心病知识图谱构建

目的：运用知识图谱技术将诊疗指南中的辨证论治过程构建为可视化的知识图谱,通过程序将输入临床表现到输出相应的中医诊断和处方用药的过程进行可视化,为中医医师直观地显示诊疗过程和数据关系,为中医药诊治冠心病的标准化和规范化提供助力,为中医药诊疗的传承和推广提供技术依托。方法：采用Neo4j联合py2neo知识图谱技术,以中华中医药学会心血管病分会发布的《冠心病稳定型心绞痛中医诊疗指南》为模式构建知识图谱,通过编程实现以临床表现的输入调用知识图谱,可视化展示冠心病稳定型心绞痛的中医规范化诊疗过程。结果：使用py2neo库调用Neo4j,从诊疗指南中提取整理好的结构化数据导入Neo4j,构建基于冠心病稳定型心绞痛中医诊疗指南的知识图谱,且该知识图谱支持图数据库查询功能。结论：该研究结合目前中医诊疗经验传承中存在的问题,针对冠心病稳定型心绞痛这个单一病种,笔者提出了一种基于凝结了中医行业专家经验和循证证据所形成的诊疗指南,实现基于中医诊疗指南和专家经验的知识图谱可视化展示过程,为直观地展现从症状输入到遣方用药的整个中医诊疗过程和辅助中医经验传承提供助力,为中医的标准化和规范化诊疗提供了一种可参考的...