Early Experiences of Haemostasis on Brain Tumour Surgery with Argon Plasma Coagulation (APC)

Summary  Objective. We first applied a novel haemostatic strategy involving Argon Plasma Coagulation (APC), an innovative no-touch electrocoagulation technique in which a high-frequency alternating current is delivered to the tissue through ionized argon gas, to brain tumour surgery, and report its usefulness and limitations.  Methods. The APC system we used comprised an APC 300 developed by ERBE Elektromedizin GmbH, Germany. We applied APC to 13 brain tumours in 12 patients (5 meningiomas, 4 sarcomas, 2 glioblastomas, and 2 pituitary adenomas). To avoid unnecessary thermal injury to the tissue as much as possible, power/gas flow settings of 20 and 40 W were used. The impact time was varied individually but was around several seconds per one impact. The argon jet (1.5–4.5 L/min) clears a field of pooled blood and evenly conducts electrical energy to the target tissue. A thin and flexible probe particularly increased the usefulness of APC for haemostasis on deep-seated skull base tumour operations under a microscope.  Conclusion. All patients were successfully treated and satisfied with the surgical results without any complications due to APC. APC appears to be an excellent alternative strategy for achieving haemostasis on vascular-rich brain tumour surgery, and may be valuable for the management of patients with coagulation defects.     

酶标仪检测数据的PC端处理及远程控制

本文利用串行通讯技术和灵活的计算机编程技巧，实现了酶标仪和计算机之间的数据通讯、分析和处理，并可脱离酶标仪面板，做到对酶标仪的远程控制。     

液基薄层细胞学检测及TBS分类在宫颈病变诊断中的应用

目的 探讨液基薄层细胞学（TCT）检测在宫颈病变诊断中的价值。方法 对648例宫颈异常的患者进行液基薄层细胞学检测，将诊断意义不明的不典型细胞（ASCUS）以上病变者行阴道镜下活检，将细胞学检测结果与活检结果作对比分析。结果 658例TET检测的患者中，宫颈病变发生率迭80．7％，其中良性病变348例，占53．7％，宫颈上皮内病变183倒，占28．2％，对183倒异常者进行阴道镜下活检与组织病理学诊断比较，符合率为90．7％。宫颈上皮内病变高发年龄为30．40岁，占37．8％。结论 TCT技术在宫颈病变的诊断中，具有简便、实用，准确率高的特点，配合阴道镜检查能及时发现官颈早期病变，是防止宫颈癌的关键。     

ACS：180碱泵加液量异常对测量结果的影响及质量控制

化学发光仪中,碱泵系统提供的碱性辅助试剂是被测物反应结束后产生化学发光的必要条件,碱泵加量精度下降,会影响测量结果的准确性。质量控制的方法分为,碱泵加液量精度测试和碱泵系统清洗以及碱泵的修复。     

资源库在医学研究生教学中的建立与应用

结合多媒体资源库的构建,介绍了资源库的构建要求以及在医学研究生教学中应用和亟需完善的一些问题。     

径向基人工神经网络在宫颈细胞图像识别中的应用

目的：探讨径向基（RBF）人工神经网络在宫颈细胞图像识别中的应用。方法：提取宫颈细胞和细胞核的15个形态学特征参数及12个色度学特征参数，对700个宫颈细胞按正常、低度鳞状上皮内病变（LSIL）、高度鳞状上皮内病变（HSIL）、宫颈癌进行分类识别。利用软件STATISTICA7．0建立网络模型并训练，用VC＋＋．NET语言调用网络。结果：RBF网络对训练集的拟合度为97．3％，对测试集的分类准确率为95．4％。在测试集中，正常细胞的识别率为96％，LSIL细胞识别率为94％，HSIL细胞识别率为100％，癌细胞识别率为88％。RBF网络输入参数的敏感度排序与细胞病理学特征基本一致。结论：RBF人工神经网络可以很好的对宫颈细胞特别是HSIL细胞进行分类识别。     

Oftalmoplejía completa izquierda por metástasis ósea de cáncer de próstata

Prognosis in prostate cancer is determined, in greater part, by the presence of metastases. Bone metastases can occur in any part of the skeleton even, for example, at the base of the skull. We present a case of a 78 year old male who, in December 2001, presented with paralysis of the third cranial nerve. The NMR and CAT scans were normal and circulating levels of PSA were elevated. He was referred to the Urology Service where the treatment guidelines included complete androgen block. Subsequently, he developed retro-orbital pain, divergent strabismus and palpebral ptosis. CAT and NMR indicated a soft tissue mass at the sphenoid level. Treatment was Gamma Knife Radio-surgery. Since August 2004, in conjunction with the latest rise in PSA, the patient's general status deteriorated considerably and he was referred to the Oncology Service. there was an increase in the paralysis of the third, fourth and sixth cranial nerve (complete left ophthalmoplegia) and left-central facial paralysis. Metastases from prostate cancer can be disseminated via the lymphatic or the blood system. Currently, there are more metastases from large-size tumours. Metastases are critical in prostate cancer because of their adverse effect on the patient's survival. Measurements of circulating levels of prostate specific antigen and prostate acid phosphatase are very useful in the clinical diagnosis of the primary tumour, or its metastases.     

2-(E)-(4-甲磺酰基)亚苄基环戊酮Mannich碱类化合物的合成及其抗炎活性

目的设计合成2-(E)-(4-甲磺酰基)亚苄基环戊酮Mannich碱类化合物,并对其抗炎活性进行初步评价.方法以环戊酮、4-甲磺酰基苯甲醛及胺类化合物为原料,经多步反应合成目标化合物,并以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性.结果与结论共合成10个新化合物,经1H-NMR和MS确证其结构.初步药理实验结果显示9个目标化合物均具有一定的抗炎活性.     

基于置信规则库的慢性萎缩性胃炎陈永灿辨证经验挖掘

[目的] 根据名老中医陈永灿(下称陈氏)诊治慢性萎缩性胃炎(chronic atrophic gastritis，CAG)的临床资料和诊疗方案，挖掘基于置信规则库(belief rule base，BRB)的CAG辨证经验。[方法] 对症候信息进行编码，将症候“有、无”分别赋值为“1、0”，以此建立CAG中医症候信息数据库。将编码后的信息作为CAG辅助诊断模型的输入特征，通过BRB挖掘症候信息与证素之间的关系，利用证据推理(evidence reasoning，ER)融合算法对输入特征进行激活处理并输出结果，最后根据输出的证素结果结合临床实际得到证型。[结果] 在收集到的572例CAG病例数据集上对CAG辅助诊断模型进行训练及测试，证实该模型准确率达到79.07%，优于传统的支持向量机(support vector machine，SVM)算法；由预测结果得到的证型主要为脾虚气滞型、寒热错杂型、肝胃郁热型。[结论] CAG辅助诊断模型在实际临床运用中具有可行性，表明人工智能技术有助于名老中医经验的传承和传播。