全文获取类型
收费全文 | 193461篇 |
免费 | 16847篇 |
国内免费 | 8411篇 |
专业分类
耳鼻咽喉 | 2559篇 |
儿科学 | 4385篇 |
妇产科学 | 2868篇 |
基础医学 | 37813篇 |
口腔科学 | 5934篇 |
临床医学 | 14450篇 |
内科学 | 25067篇 |
皮肤病学 | 4914篇 |
神经病学 | 11077篇 |
特种医学 | 4210篇 |
外国民族医学 | 118篇 |
外科学 | 15817篇 |
综合类 | 28591篇 |
现状与发展 | 48篇 |
预防医学 | 7681篇 |
眼科学 | 3744篇 |
药学 | 15734篇 |
30篇 | |
中国医学 | 5327篇 |
肿瘤学 | 28352篇 |
出版年
2024年 | 247篇 |
2023年 | 2518篇 |
2022年 | 3653篇 |
2021年 | 6590篇 |
2020年 | 5932篇 |
2019年 | 5779篇 |
2018年 | 5995篇 |
2017年 | 6378篇 |
2016年 | 6627篇 |
2015年 | 7550篇 |
2014年 | 11333篇 |
2013年 | 12460篇 |
2012年 | 10803篇 |
2011年 | 12284篇 |
2010年 | 10103篇 |
2009年 | 9789篇 |
2008年 | 10295篇 |
2007年 | 10423篇 |
2006年 | 9448篇 |
2005年 | 8574篇 |
2004年 | 7617篇 |
2003年 | 6662篇 |
2002年 | 5395篇 |
2001年 | 4722篇 |
2000年 | 3978篇 |
1999年 | 3586篇 |
1998年 | 3426篇 |
1997年 | 3147篇 |
1996年 | 2896篇 |
1995年 | 2596篇 |
1994年 | 2336篇 |
1993年 | 1938篇 |
1992年 | 1638篇 |
1991年 | 1503篇 |
1990年 | 1211篇 |
1989年 | 1105篇 |
1988年 | 1042篇 |
1987年 | 844篇 |
1986年 | 762篇 |
1985年 | 1011篇 |
1984年 | 923篇 |
1983年 | 625篇 |
1982年 | 648篇 |
1981年 | 528篇 |
1980年 | 461篇 |
1979年 | 362篇 |
1978年 | 261篇 |
1977年 | 204篇 |
1976年 | 158篇 |
1975年 | 71篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
《European journal of surgical oncology》2022,48(5):1062-1067
BackgroundSurgical resection is recommended for patients with resectable acinar cell carcinoma (ACC). The aim of this study was to investigate the clinical characteristics and surgical outcomes of resectable ACC in comparison to pancreatic ductal adenocarcinoma (PDAC).MethodA retrospective analysis was performed on all patients who consecutively underwent radical resection with pathologically confirmed ACC and PDAC from December 2011 to December 2018. Clinicopathologic characteristics and follow-up information were analyzed. A 1:3 propensity score matching (PSM) method was used to minimize the bias between ACC and PDAC.ResultsA total of 26 patients with ACC and 1351 with PDAC were included. Compared to PDAC, ACC tended to be larger (4.5 vs. 3.0 cm; p < 0.001) and more frequently located in the pancreatic body/tail (61.5% vs. 36.6%, p = 0.009), with lower total bilirubin levels, lower neutrophil lymphocyte ratio (NLR) levels and lower carbohydrate antigen 19-9 (CA19-9) levels and carcinoembryonic antigen (CEA) levels. There was no difference in postoperative morbidities in patients with ACC and PDAC. The median OS and RFS were longer in ACC when compared to PDAC (OS: 43.5 mo vs. 19.0 mo, p = 0.004; RFS: 24.5 mo vs. 11.6 mo, p = 0.023). After the 1:3 PSM, ACC remained to be a better histological type for OS (p = 0.024), but had comparable RFS with PDAC (p = 0.164).ConclusionPatients with ACC after radical resection had better OS than that with PDAC. However, ACC is also an aggressive tumor with a similar trend of RFS with PDAC after the matching, necessitating the multidisciplinary treatment for resectable ACC disease. 相似文献
62.
《Vaccine》2021,39(45):6601-6613
AKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic. The Fc moiety is designed to enhance immunogenicity by increasing uptake via Fc-receptors (FcγR) on Ag-presenting cells (APCs) and prolonging exposure due to neonatal Fc receptor (FcRn) recycling. AKS-452 induced approximately 20-fold greater neutralizing IgG titers in mice relative to those induced by SP/RBD without the Fc moiety and induced comparable long-term neutralizing titers with a single dose vs. two doses. To further enhance immunogenicity, AKS-452 was evaluated in formulations containing a panel of adjuvants in which the water-in-oil adjuvant, Montanide™ ISA 720, enhanced neutralizing IgG titers by approximately 7-fold after one and two doses in mice, including the neutralization of live SARS-CoV-2 virus infection of VERO-E6 cells. Furthermore, ISA 720-adjuvanted AKS-452 was immunogenic in rabbits and non-human primates (NHPs) and protected from infection and clinical symptoms with live SARS-CoV-2 virus in NHPs (USA-WA1/2020 viral strain) and the K18 human ACE2-trangenic (K18-huACE2-Tg) mouse (South African B.1.351 viral variant). These preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain. 相似文献
63.
64.
Luis Veloza Cristina Teixido Natalia Castrejon Fina Climent Ana Carri Marta Marginet Davide Soldini Blanca Gonzlez‐Farr Inmaculada Ribera‐Cortada Armando Lopez‐Guillermo Eva Gonzlez‐Barca Adriana Sierra Mileyka Herrera Cndida Gmez Adriana Garcia Olga Balagu Elias Campo Antonio Martinez 《Histopathology》2019,75(6):799-812
65.
66.
67.
《International journal of oral and maxillofacial surgery》2021,50(11):1422-1428
It is clinically challenging to identify oral leukoplakias that have a high risk of undergoing malignant transformation. The aim of this retrospective study was to elucidate the associations between malignant transformation of oral leukoplakias and various clinicopathologic factors. Patients with a diagnosis of clinical oral leukoplakia, verified through histopathologic examination and with access to digital images of the lesion, were retrospectively included for the period 2003–2013. Using the clinical images, all lesions were re-evaluated regarding diagnosis and clinical subtype. Of the 234 included patients, with a median follow-up of 9 years, 27 (11.5%) developed oral squamous cell carcinoma. Among the clinicopathologic factors investigated, non-homogeneous oral leukoplakia (OL), OL with dysplasia, and OL localized to the tongue showed statistically significant increased rates of malignant transformation in the multivariate Cox regression analysis. Non-homogeneous OL showed a 15.2-times higher transformation rate than homogenous OL (P < 0.001). Dysplastic leukoplakias developed into carcinomas 2.4-times more often than did non-dysplastic leukoplakias (P = 0.048). OL located on the tongue showed a 2.8-times higher malignant transformation rate than OLs at other oral locations (P = 0.018), when other locations were combined into one group. Non-homogeneous OL, OL with dysplasia, and OL localized to the tongue have higher transformation rates. 相似文献
68.
目的 探讨人格特征对喉鳞状细胞癌(LSCC)患者术后近期心理健康状况的影响。方法 纳入2017年1月—2019年12月在湖北省肿瘤医院行手术治疗的119例男性LSCC患者,术后5~7 d采用SCL-90、SAS、SDS自评量表评估术后心理状态,采用EPQ问卷测评患者的人格特征。多元线性逐步回归方法分析LSCC患者术后近期SAS和SDS评分的影响因素。结果 男性LSCC患者术后SCL-90、SAS、SDS得分显著高于中国常模(P≤0.05),EPQ中精神质(P)量表和神经质(N)量表得分高于中国常模(P<0.01)。男性LSCC患者术后躯体化、强迫、焦虑、抑郁、敌对、恐怖、偏执、精神病性因子得分均显著高于中国常模(P<0.05)。家庭收入、手术方式、术后近期是否行放化疗、P和N人格特征是术后SAS评分的影响因素(均P<0.01);家庭收入、手术方式、术后近期是否行放化疗和N人格特征是术后SDS评分的影响因素(P<0.01)。结论 LSCC患者术后近期存在抑郁、焦虑等心理障碍;具有P和N人格特征;家庭收入、手术方式、术后近期是否行放化疗以及P和N人格特征是影响术后SAS及SDS评分的独立危险因素。 相似文献
69.
70.
《Saudi Pharmaceutical Journal》2022,30(6):655-668
Most vaccines approved by regulatory bodies are administered via intramuscular or subcutaneous injections and have shortcomings, such as the risk of needle-associated blood infections, pain and swelling at the injection site. Orally administered vaccines are of interest, as they elicit both systemic and mucosal immunities, in which mucosal immunity would neutralize the mucosa invading pathogen before the onset of an infection. Hence, oral vaccination can eliminate the injection associated adverse effects and enhance the person's compliance. Conventional approaches to manufacturing oral vaccines, such as coacervation, spray drying, and membrane emulsification, tend to alter the structural proteins in vaccines that result from high temperature, organic and toxic solvents during production. Electrohydrodynamic processes, specifically electrospraying, could solve these challenges, as it also modulates antigen release and has a high loading efficiency. This review will highlight the mucosal immunity and biological basis of the gastrointestinal immune system, different oral vaccine delivery approaches, and the application of electrospraying in vaccines development. 相似文献