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991.
Barry L. Eppley M.D. D.M.D. Don-John Summerlin D.M.D. M.S. Christopher D. Prevel M.D. A. Michael Sadove M.D. 《Aesthetic plastic surgery》1994,18(4):413-416
Based on previous experimental connective tissue work, the use of a positively charged dextran-based biomaterial in subcutaneous tissue sites was evaluated. After hydration with saline, the biomaterial was injected beneath the abdominal skin in rats. A robust macrophage response was initially seen at 30 days without acute inflammation. By one year postoperatively, extensive intermaterial fibroblast and collagen ingrowth had occurred. No evidence of a foreign-body or chronic inflammatory response was seen. These preliminary findings suggest good tissue compatibility of this biomaterial and suggests that when combined with a biocompatible liquid medium, the potential for development of a bioactive dermal and subcutaneous injectable substance exists. 相似文献
992.
993.
脂溶性维生素注射液的细菌内毒素检查法,收载于卫生部药品标准中(1996年),其限值为L≤1Eu·ml~(-1)。然而,试验中发现,该产品对一些厂生产的鲎试剂有很强的干扰作用,无法测定其细菌内毒素。通过试验,确定了二个厂生产的鲎试剂对其作细菌内毒素检查。 相似文献
994.
荧光法测定磺胺嘧啶钠注射液的含量夏维杰,柳雅君(沈阳军区总医院药剂科,沈阳110015)孙国祥(沈阳药科大学分析教研室,沈阳110015)磺胺嘧啶钠(SD-Na)注射液是一种常用的抗菌剂。中国药典收载的定量方法SD-Na用永停滴定法。本文提出用对二甲... 相似文献
995.
吲哚美辛脂质体注射液的制备、含量测定及稳定性 总被引:3,自引:0,他引:3
本文报道了吲哚美辛脂质体制备方法,建立了紫外分光光度法测定吲哚美辛的含量,方法的平均回收率为101.5%,变异系数0.71%。考察了不同pH值对吲哚美辛脂质体稳定性的影响。结果表明所制备的吲哚美辛脂质体在pH5.5最稳定。 相似文献
996.
Burana-Osot J Ungboriboonpisal S Sriphong L 《Journal of pharmaceutical and biomedical analysis》2006,40(5):1068-1072
A stability-indicating HPLC assay method has been developed and validated for medroxyprogesterone acetate (MPA) in bulk drug and injectable suspension. An isocratic RP-HPLC was achieved on a Hichrom C18 column (150 mm × 4.6 mm i.d., 5 μm) utilizing a mobile phase of methanol 0.020 M acetate buffer pH 5 (65:35, v/v) and a photodiode array detector at 245 nm. The stress testing of MPA was carried out under acidic and alkaline hydrolysis, and oxidation conditions. MPA was well resolved from its degradation products, a main related substance (megestrol acetate) and two preservatives (methyl paraben and propyl paraben) with the resolution ≥2. The proposed method was validated for selectivity, linearity, accuracy, precision and solution stability. The method was found to be suitable for the quality control of MPA in bulk drug and injections as well as the stability-indicating studies. 相似文献
997.
实验性大鼠肺血栓栓塞症中ICAM-1、P-选择素的变化及红花注射液对其的影响 总被引:6,自引:0,他引:6
目的动态观察红花注射液对大鼠肺血栓栓塞症(PTE)中血管内皮细胞间黏附分子-1(ICAM-1)和P-选择素的影响.方法将Wistar大鼠随机分为正常组、模型组和治疗组,用颈静脉注入自体血凝块制备动物模型.治疗组在模型建立后立即自鼠尾静脉注射红花注射液2 ml/kg,每天1次,共5天.各组大鼠分别于栓塞后1、3、24、72、120 h处死,行病理观察;采用免疫组化和原位杂交的方法检测肺血管内皮ICAM-1和P选择素蛋白及mRNA的表达水平.结果与正常组比较,模型组大鼠肺栓塞后病理可见肺动脉血栓形成,炎性反应明显;肺血管内皮ICAM-1蛋白及mRNA表达在栓塞后3 h开始增高(P<0.01),而P-选择素蛋白及mRNA表达在栓塞后1 h开始增高(P<0.01).治疗组大鼠病理损伤减轻,肺血管内皮ICAM-1和P-选择素水平均下降(P<0.01).结论红花注射液可减轻大鼠PTE时的肺损伤,这种作用可能是通过下调血管内皮上的黏附分子来实现的. 相似文献
998.
Objective: To investigate the effects of Compound Glycyrrhizin Injection (CGI) on liver function and cellular immunity of children with infectious mononucleosis complicated liver impairment (IM-LI) and to explore its clinical therapeutic effect. Methods: Forty-two patients with IM-LI were randomly assigned, according to the randomizing number table, to two groups, 20 in the control group and 22 in the treated group. All the patients were treated with conventional treatment, but to those in the treated group, CGI was given additionally once a day, at the dosage of 10 ml for children aged below 2 years, 20 ml for 2-4 years old, 30 ml for 5-7 years old and 40 ml for 8- 12 years old, in 100-200 ml of 5% glucose solution by intravenous dripping. The treatment lasted for 2 weeks. T lymphocyte subsets and serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) were detected before and after treatment. Besides, a normal control group consisting of 20 healthy children was also set up. Results: Baseline of the percentage of CD3^+ , CD8^+ lymphocyte and serum levels of ALT, AST, TBiL in the children with IM-LI were markedly higher, while the percentage of CD 4^+ lymphocyte and the CD4^+/CD8^+ ratio was markedly lower in IM-LI children as compared with the corresponding indices in the healthy children ( P〈0.01 ). These indices were improved after treatment in both groups of patients, but the improvement in the treated group was better than that in the control group (P〈0.01). Conclusion: Cellular immunity dysfunction often occurs in patients with IM-LI, and CGI treatment can not only obviously promote the recovery of liver function, but also regulate the immune function in organism. 相似文献
999.
BACKGROUND
Ganglia are the most common benign soft tissue tumours of the hand. Although benign, a significant number of patients with wrist ganglia consult with their general practitioners, and ultimately the hand surgeon, complaining of pain. A great number of patients are concerned about the cosmetic appearance, and an equally significant number genuinely believe that the ganglion is a cancer. There are several management options resulting in varying degrees of success. These include observation only, surgical excision, aspiration only, aspiration with injection of methylprednisolone, and aspiration with injection of methylprednisolone and hyaluronidase.OBJECTIVE
The main objective was to investigate the effectiveness and safety of sodium tetradecyl sulfate as a sclerosing agent after aspiration of wrist ganglia.METHODS
Initial data were collected prospectively during a period of 48 months. Following this, patients were sent a postal survey at least two years after they had received treatment to access the levels of recurrence and persistent complications.RESULTS
In the short term, 90% of the patients achieved complete resolution after one episode of aspiration and injection. However, there was only a 65% cure rate after two to five years. Complications were few and not significant.CONCLUSION
Sodium tetradecyl sulfate is an effective sclerosing agent after aspiration of wrist ganglia with an excellent short-term efficacy and a long-term cure rate comparable to that of surgical excision. 相似文献1000.
Z. S. Herman K. Kmieciak-Kołada J. Słominska-żurek R. Szkilnik 《Psychopharmacology》1972,27(3):223-232
The influence of acetylcholine (Ach) injected into the lateral ventricle of the brain on the behaviour of white, male Wistar rats was investigated, together with the effect on the levels of noradrenaline (NA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) in discrete brain areas. Ach in doses of 1–100 g caused a decrease of locomotor activity of rats. A dose of 0.1 g produced the same effect in medium and high activity rats, but did not affect the behaviour of low activity rats. Atropine injected i.p. in a dose of 2.5 mg/kg abolished the behavioural effect of Ach. 50 g of Ach caused various changes of NA, 5-HT and 5-HIAA level in discrete brain areas. No correlation between biochemical and behavioural changes were seen. 相似文献