当前高校设备维修管理服务SWOT分析与战略探讨

随着高校对教学科研仪器设备投入的不断增加，仪器设备维修工作的重要性日益突出。通过SWOT分析法，对高校设备维修服务的内外因素进行分析，找出当前高校设备维修工作的内在优势和弱势、外在机会和挑战，并提出在高校设备维修服务战略方面的进攻调整防御和生存四种相应策略的思考。     

阿托伐他汀对系膜增殖性肾炎大鼠肾组织细胞外基质和纤溶酶原激活剂抑制物-1表达的影响

目的：观察阿托伐他汀对系膜增殖性肾炎（MsPGN）大鼠肾组织细胞外基质（ECM）和纤溶酶原激活剂抑制物-1（PAI-1）表达的影响，探讨其肾脏保护作用的机制。方法：采用抗胸腺细胞血清诱发的MsPGN大鼠模型，将SD大鼠随机分为正常对照组、肾炎模型组、小剂量阿托伐他汀治疗组（8mg·kg^-1·d^-1）和大剂量阿托伐他汀治疗组（16mg·kg^-1·d^-1）。治疗12d后。检测各组大鼠血总胆固醇（CHOL）、甘油三酯（TG）、血肌酐（Scr）和24h尿蛋白，以及肾组织Ⅳ型胶原（Col Ⅳ）、纤维结合蛋白（FN）和PAI-1的表达。结果：阿托伐他汀治疗组大鼠24h尿蛋白、肾组织Col Ⅳ、FN和PAI-1 mRNA的表达明显下降。肾组织病理改变明显改善，与模型组相比有统计学差异（P〈0．05），且呈剂量依赖关系。其中肾炎模型组尿蛋白（30．34±0．62）mg／d。阿托伐他汀小剂量治疗组（21．17±0．79）mg／d，大剂量治疗组（9．77±0．54）mg／d。同时，各组血脂水平无明显差异（P〉0．05）。结论：阿托伐他汀可显著改善MsPGN大鼠肾脏病变，抑制肾组织ECM成分和PAI-1的表达。     

异体脱钙骨基质复合bBMP修复兔桡骨骨缺损

目的：探讨异体脱钙骨基质复合BMP修复节段性骨缺损的能力。方法：64只新西兰大白兔采用桡骨15mm节段性骨缺损模型，随机分为4组，A组植入异体脱钙骨基质(Demineralized Bone Matrix,DBM)与牛骨形态发生蛋白(Bovine Bone Morphogentic Protein,bBMP)复合材料，B组植入异体DBIM，C组植入异体骨粒，D组为空白对照组。术后4、8、12、16w，进行放射学检查、病理组织学检查和计算机图像分析新生骨面积。结果：异体DBM与bBMP复合材料组骨生成、新骨面积和骨连接情况明显优于异体DBM组、异体骨粒组和空白对照组。结论：异体DBM复合BMP材料通过骨诱导和骨传导两种方式修复骨缺损，是一种较为理想、具有高效成骨活性的植骨材料。     

增生性玻璃体视网膜病变基质金属蛋白酶的定量研究

目的:研究增生性玻璃体视网膜病变(proliferative vitreoretinopathy,PVR)玻璃体中基质金属蛋白酶(matrix metalloproteinases,MMPs)的表达,探讨MMPs在PVR病理过程中的作用。方法:PVR患者采用标准三切口巩膜扁平部玻璃体切割术(pars plana vitrectomy,PPV),取未稀释的玻璃体21只眼,PPV术后复发的玻璃体腔液20只眼,意外死亡的正常人玻璃体10只眼,采用明胶酶谱分析法定量分析MMP-2和MMP-9活性水平。结果:PVR玻璃体有MMP-2活性水平增高,与正常玻璃体比较差异有显著性意义(P<0.05)。21眼PVR玻璃体中13只眼有MMP-9活性水平增高,平均(171.52±13.17)扫描单位。20眼PPV术后PVR复发的玻璃体腔液19只眼有MMP-9活性水平增高,平均(156.01±37.21)扫描单位。正常人玻璃体无MMP-9的表达。结论:PVR玻璃体有MMP-2和MMP-9活性水平增高,MMP-9活性水平增高可能与术后PVR复发有关。眼科学报2003;19:130-132。     

Structure and Behavior in Hydrophilic Matrix Sustained Release Dosage Forms: 4. Studies of Water Mobility and Diffusion Coefficients in the Gel Layer of HPMC Tablets Using NMR Imaging

Purpose. The purpose of this study was to characterise the water mobility in the gel layer of hydrating HPMC tablets. Water mobility in the gel layer of different HPMCs was studied. Methods. NMR imaging, a non-invasive technique, has been used to measure the spatial distribution of self-diffusion coefficient (SDC) and T₂ relaxation times across the gel layer. Results. It has been shown that there is a water mobility gradient across the gel layer of HPMC tablets. Although SDC and T₂ relaxation times in the outer parts of the gel layer approached that of free water, in the inner parts they decreased progressively. Water mobility and SDC in the gel layer of different HPMCs appeared to vary with degree of substitution of the polymer and the lowest values were obtained across the gel layer of K4M tablets. Conclusions. Water mobility varies across the gel layer of hydrating HPMC tablets and it is dependent on the degree of substitution of the polymer.     

组织工程学研究中偏光显微镜的应用

偏光显微镜是地质界用来观察晶体矿物的重要仪器。其理论基础是结晶光学，特点是即可观察结构，又可根据光学性质（折光率值不同）来判断成分。通过在研究ＮＥＣＭ和注射性胶原制作的过程中，用偏光显微镜和光镜观察同一部位的组织片，加以对比分析。因为胶原是生物体内的特殊“晶体”，故认为偏光显微镜应用在组织工程研究中，不仅开阔了观察领域，而且是重要的观测手段和方法。用偏光显微镜观察了猪骨ＥＣＭ胶原框架，以及注射性胶原制作过程中胶原变化特点。认为本方法简单不需染色，并可特异的观察到胶原的分布和走行。     

The incidence, timing, and predisposing factors of germinal matrix and intraventricular hemorrhage (GMH/IVH) in preterm neonates

Background Germinal matrix and intraventricular hemorrhage (GMH/IVH) is a known complication occurring in the first week of life in preterm neonates. However, the precise time of its occurrence and the ideal time to perform diagnostic imaging studies remain controversial. The purpose of this paper is to address these two issues in our patient population to allocate our resources to those at highest risk.Materials and methods This study included 282 premature newborns (under 37 weeks of gestation) that were admitted to our neonate ICU in a year’s time and screened for GMH/IVH. They were grouped in four categories according to their weight at birth, and according to their gestational age. All patients had a daily cranial ultrasound during the first week. It was then repeated once in the second week and once in the third.Results We found that the incidence of GMH/IVH among preterm neonates was 44.68%. It was inversely related to the weight and the age of the newborn. The onset of bleeding coordinated with the occurrence of hypoxia and respiratory distress requiring mechanical ventilation. The majorities occurred in the first 7 days of life; they were mostly grade I and II according to the Papule classification and silent for the most part. Complications were present in 41% of the survivors.     

Glycosaminoglycan Supplementation Promotes Nerve Regeneration and Muscle Reinnervation

This study shows that treatment of rats with exogenous glycosaminoglycans stimulates peripheral nerve regeneration, increases the abundance of mRNAs for myelin proteins and promotes muscle reinnervation. After the sciatic nerve had been crushed the number of regenerating axons in the distal stump was markedly and highly significantly increased by glycosaminoglycan treatment throughout the experimental period. The increased number of axons was correlated with increased axon and fibre (axon + myelin) diameter. The abundance of mRNAs for P_o protein and myelin basic protein of regenerating nerves was also affected by treatment with glycosaminoglycans. The increase in mRNA was also observed in the contralateral unlesioned nerve. Such a phenomenon did not occur in saline-treated rats. Glycosaminoglycan treatment markedly increased the number of muscle fibres reinnervated and accelerated the restoration of muscle twitch tension elicited by nerve stimulation. The effect was particularly evident during the early stages (16 and 21 days after nerve crush) of muscle reinnervation.     

小鼠骨髓基质细胞系QXMSC1促进骨髓移植后的造血重建

目的：观察骨髓基质细胞系QXMSC1在骨髓移植后早期能否加速造血重建。方法：用脾克隆形成单位（CFU-S）测定QXMSC1对造血干细胞的影响。计数每根股骨有核细胞数，用半固体琼脂克隆形成法测定粒单系祖细胞（CFU－GM），微量甲基纤维素法测定红系祖细胞（CFU-E及BFU－E）。结果：QXMSC1细胞可明显增加CFU－S克隆数。在骨髓移植后第10天，QXMSC1可增加骨髓有核细胞数，增加CFU－GM、CFUE克隆数。移植后第20天，这些作用更明显，且对BFU-E也有明显的刺激作用。结论：骨髓基质细胞系QXMSC1与骨髓细胞共移植可明显促进骨髓移植后早期造血功能重建。