论药物有机化学中生物大分子课程教学

生物大分子对于包括药学在内的生命科学显得越来越重要，因此药学基础课程有机化学中生物大分子这部分课程需要得到更加的重视。本文介绍了从我们近几年在这部分课程的教学实践中总结出的行之有效的教学经验。     

Mayoclinic健康咨询服务网站介绍

梅奥医学诊疗中心是享誉世界的非营利性综合医疗合作中心。重点介绍Mayoclinic健康咨询服务网站,包括网站的结构、功能及内容,目的是为国内读者了解梅奥医学诊疗中心咨询服务以及为同类型网站建设提供帮助。     

明代医家李梴养生学术思想探析

明代医家李梴非常注重养生,提出了很多关于养生的观点,如养生抗衰老要以预防为主,应注重体质锻炼,以及用灸养生防病说、保养勿用药说以及不贪不躁不妄可以却未病而尽天年理论,对后人有很大启发。     

《麻醉学专业导论》课程教学体系的构建、实践与评价

目的  构建《麻醉学专业导论》教学体系，评价教学效果。方法  在原《麻醉学专业导论》教学体系基础上，拓展实验教学与理论授课专题，构建理论与实践相结合的新型教学体系。通过问卷调查，从专业认知能力、后续课程学习动力、制定职业与发展规划等3个方面，分析接受传统教学体系2014-2017级学生与接受新型教学体系2018-2019级学生的教学效果。结果  新型教学体系分别从“了解麻醉学的地位、专业特色、工作领域”“为今后学习基础医学课程和临床医学课程、参加临床见习/实习”“确定职业规划、了解执业医师资格考试、准备研究生考试”等方面提高了传统教学对学生的指导与引导作用。结论  理论与实践相结合的教学体系强化了学生专业认知能力的培养、强化了学生后续课程学习的动力、强化了学生职业规划与发展的引导，更大程度地实现了“了解专业、热爱专业、学习专业、胜任专业”的教学目标。     

CT Findings of Colonic Complications Associated with Colon Cancer

A broad spectrum of colonic complications can occur in patients with colon cancer. Clinically, some of these complications can obscure the presence of underlying malignancies in the colon and these complications may require emergency surgical management. The complications of the colon that can be associated with colon cancer include obstruction, perforation, abscess formation, acute appendicitis, ischemic colitis and intussusception. Although the majority of these complications only rarely occur, familiarity with the various manifestations of colon cancer complications will facilitate making an accurate diagnosis and administering prompt management in these situations. The purpose of this pictorial essay is to review the CT appearance of the colonic complications associated with colon cancer.     

泽泻炮制及副作用

泽泻性寒,味甘、淡,归肾、膀胱经,具有利水渗湿、泄热之功效。古代泽泻经盐炒、麸炒、土炒等炮制后,水溶性煎生物较生品均有不同程度增加,尤以盐制品为高,利于有效成分煎出。现代炮制主要包括生泽泻、清炒泽泻、麸炒泽泻、土炒泽泻及盐炙泽泻等,最常用为麸炒泽泻和盐泽泻,泽泻生品以利水渗湿为主,麸炒泽泻以渗湿和脾、降浊生清为主,盐炙泽泻引药下行,增强滋阴泻热及利尿作用。泽泻无明显副作用,少数出现轻度食减退、嘈杂、肠鸣、腹泻等胃肠反应。     

不稳定斑块破裂引起变异性心绞痛1例

背景:典型变异性心绞痛是心绞痛并发心电图一过性ST段抬高,由冠脉痉挛引起。病例:一位68岁男性变异性心绞痛患者,冠脉造影后行光学相干断层扫描（Optical coherence tomography,OCT）发现右冠状动脉近端薄壁不稳定粥样斑块破裂。冠脉痉挛是变异性心绞痛的发病机制,而冠脉粥样硬化可能是引起冠脉痉挛的基础疾病,薄壁不稳定粥样斑块的破裂可能是其潜在病因。结论: 不稳定斑块破裂可能会引起变异性心绞痛发作。（明确“撕裂”与“破裂”两个病理生理过程）     

8个多年生禾本科牧草引种试验

在新疆察布查尔县中洲牛场试验地,对8个多年生禾本科牧草进行了物候期、产草量和适应性研究.结果表明:两种高羊茅(加拿大)、(特克斯)和披碱草(昭苏)品种在适应性、产草量和草质量方面表现较好,适宜在该地区大量推广种植,可以作为人工草地建设或天然草场改良的优质牧草.     

Efficient Introduction of Macromolecules and Oligonucleotides into Brain Capillary Endothelial Cells Using HVJ-Liposomes

Abstract

In this study, we examined the feasibility of introducing macromolecules into cultured mouse brain capillary endothelial cells (MBEC4 cells) by utilizing the hemagglutating virus of Japan (HVJ)-liposomes with fusogenic activity. We used fluorescein isothiocyanate dextran (FITC-Dextran) and FITC-labeled oligodeoxynucleotide (FITC-ODN) as models of a macromolecule and an ODN, respectively. Intracellular fluorescence appeared rapidly after the exposure of MBEC4 cells to FITC-Dextran-containing HVJ-liposomes, and remained detectable for at least 3 days. Only a control level of intracellular fluorescence was seen after treatment with FITC-Dextran alone, FITC-Dextran with empty HVJ-liposomes or FITC-Dextran-containing liposomes without fusogenic activity. In the early phase after administration (0–30 min), the introduction of FITC-Dextran into MBEC4 cells by the HVJ-liposome method resulted in a rapid and time-dependent increase of intracellular fluorescence intensity. Moreover, FITC-ODN was also introduced into MBEC4 cells by the HVJ-liposome method, although FITC-ODN alone was not introduced. These results indicate that the HVJ-liposome method is useful for the efficient introduction of macromolecules, including ODN, into brain capillary endothelial cells.