叶底珠枝叶水提物对小鼠急性肝损伤的保护作用

目的:叶底珠水提取物对四氯化碳引起小鼠急性肝损伤的保护作用。方法:60只小鼠随机分为正常组、模型组、高剂量组、中剂量组、低剂量组、阳性对照组。高、中、低剂量组分别按2.0,1.0,0.5g/kg-1灌胃叶底珠水提取物;阳性对照组按0.1g/kg-1水飞蓟宾灌胃;正常组和模型组给予等体积生理盐水。第5天给药1小时后,模型组、高、中、低剂量组和阳性对照组按0.015ml.g-1腹腔注射0.1%CCl4,正常对照组腹腔注射等体积生理盐水。测定小鼠血清天冬氨酸转氨酶(aspartate transaminase,AST)、丙氨酸氨基转移酶(alanine transaminase,ALT)活性和肝组织超氧化歧化酶(superoxide dismutase,SOD)活性及丙二醛(malondialdehyde,MDA)含量。结果:叶底珠水提取物能显著降低CCl4所致小鼠血清ALT和AST活性(P0.01),同时升高肝组织SOD活性(P0.01),降低肝组织MDA的含量(P0.01)。结论:叶底珠水提取物对CCl4所致小鼠急性肝损伤具有保护作用。     

Discussion of the process control of large-scale instruments and equipment procurement in State Key Laboratory

In recent years, the usage, management and benefit of large-scale scientific research instruments and equipment in scientific research institutes have been a leading issue in the management of scientific research institutes. Within the scope of equipment budget, it is necessary for each equipment acquisition team to conduct a round of communication, coordination and negotiation with suppliers in order to improve the cost performance of equipment procurement and maximize the performance index to meet the needs of scientific research. By introducing the practical experience of the State Key Laboratory in purchasing imported equipment and managing large-scale instruments, this paper probes into the management process of the imported large-scalescientific research tax-free equipment of scientific research institutes, and explores the system and methods to guarantee and improve the efficiency of large-scale instruments in scientific research institutes from the aspects of policy, funds and technology.     

医用耗材集中采购模式回顾与探讨

医用耗材的招标采购是一个系统工程,对医用耗材采用集中招标的采购模式,可以保证临床使用到质量优良的医用耗材,控制产品价格的虚高,有利于降低医疗成本,减轻患者负担。在规范医用耗材采购方式和流通渠道的同时,对集中采购的过程也需要不断总结与完善。     

暗标评标法在高职院校图书招标采购中的应用

针对现阶段高职院校图书馆图书公开招标采购中的各种问题,结合其他行业采购中暗标评标法的经验,探讨了暗标评标法在图书招标中的可操作性和流程。     

The use of ‘off-the-shelf’ foot orthoses in the reduction of foot symptoms in patients with early rheumatoid arthritis

BackgroundFoot pain in patients diagnosed with early rheumatoid arthritis is common.ObjectivesTo investigate effects of off-the-shelf foot orthoses on outcomes of swollen and tender joints, and pain, in patients with early rheumatoid arthritis.MethodsThirty-five patients with painful and swollen foot joints were recruited. None had previously used foot orthoses or had contraindications to their use. Any patients with concomitant musculoskeletal disease, endocrine disorders, and neurological disease, were excluded. At baseline, participants were prescribed a customised off-the-shelf foot orthosis with chair-side modifications. Data was collected at baseline, three and six months. Foot pain (using Visual Analogue Scale) and the number of tender and swollen foot joints was measured.ResultsThere was a trend towards a reduction in the number of swollen and tender joints by 3 months with a further improvement by 6 months. Statistically (p < 0.05) and clinically significant reductions in pain levels were also noted.ConclusionPatients diagnosed with early RA may benefit from using off-the-shelf foot orthoses with the majority of their pain reduction occurring within the first 3 months of use, but with some small further symptomatic improvement up to 6 months. There was a tendency to a reduction in swollen and tender joints although more studies are required to substantiate these findings.     

药品顺加作价的作用和效果分析

医院药品采购,在招标的基础上进行顺加作价是对药品招标工作的重大改进.顺加作价采用中标价为基准价,使零售价的确定有了合理的标准,所形成的零售价真正实现了降价.但新出台的顺加作价政策在实践中也反映出一些不完善之处.对医院的亏损及其补偿措施、潜在的负面作用等问题需要特别给予关注和设法解决.文章提出了需要关注的问题和解决问题的思路.     

光子嫩肤技术治疗面部色素性皮肤病的效果观察

目的:探讨光子嫩肤技术在面部色素性皮肤病治疗中的临床应用效果。方法:回顾分析86例面部色素性皮肤病患者的临床资料,对患者采用光子多功能治疗仪进行治疗,观察分析治疗效果。结果:经治疗,雀斑患者、痤疮后色素沉着患者、脂溢性角化患者、黄褐斑患者以及其他色素沉着患者的总有效率分别为95.2%、95.2、66.7%、50.0%和40.0%。患者无严重不良反应症状。结论:采用光子嫩肤技术能有效治疗面部色素皮肤病,尤其是对雀斑、痤疮后色素沉着治疗效果显著。     

Juvenile fibromyalgia: Guidance for management

Juvenile fibromyalgia (JFM) is a disease in which patients complain of acute and chronic severe pain, an overt primary cause for which cannot be found or surmised. Although patients with JFM mainly complain of systemic pain or allodynia in the medical interview and physical examination, the concept of the disease is the total sum of painful illness, chronic fatigue, hypothermia and many other autonomic symptoms and signs. Many issues are interacting including individual traits (personality, temperament, sensitivity, memory of pain; age: early adolescence), individual states (self‐esteem, anxiety, developmental level), and external stressors (parent especially mother, school environment). JFM is diagnosed on the combination of disease history, physical examination to determine the 18 tender points and allodynia, pain from gently touching their hair, and negative results of blood tests (inflammatory markers, thyroid function, myogenic enzymes). The goals of treatment are the following: restoration of function and relief of pain. Psychological support is advocated. Although the exact number of patients with JFM is still to be elucidated, it seems to be growing because pediatric rheumatologists in Japan encounter children with a wide variety of musculoskeletal pains. This guideline describes how to diagnose JFM in children and how to treat them appropriately.