全文获取类型
收费全文 | 126105篇 |
免费 | 9780篇 |
国内免费 | 3636篇 |
专业分类
耳鼻咽喉 | 988篇 |
儿科学 | 2330篇 |
妇产科学 | 1786篇 |
基础医学 | 7200篇 |
口腔科学 | 2878篇 |
临床医学 | 15077篇 |
内科学 | 18675篇 |
皮肤病学 | 2312篇 |
神经病学 | 6485篇 |
特种医学 | 4064篇 |
外国民族医学 | 40篇 |
外科学 | 12275篇 |
综合类 | 18372篇 |
现状与发展 | 23篇 |
一般理论 | 2篇 |
预防医学 | 5140篇 |
眼科学 | 2038篇 |
药学 | 11149篇 |
73篇 | |
中国医学 | 11105篇 |
肿瘤学 | 17509篇 |
出版年
2024年 | 193篇 |
2023年 | 2173篇 |
2022年 | 3250篇 |
2021年 | 5541篇 |
2020年 | 5168篇 |
2019年 | 4660篇 |
2018年 | 4455篇 |
2017年 | 4934篇 |
2016年 | 5245篇 |
2015年 | 5027篇 |
2014年 | 9056篇 |
2013年 | 11754篇 |
2012年 | 7423篇 |
2011年 | 7901篇 |
2010年 | 6522篇 |
2009年 | 6016篇 |
2008年 | 5918篇 |
2007年 | 6319篇 |
2006年 | 5659篇 |
2005年 | 5009篇 |
2004年 | 4079篇 |
2003年 | 3698篇 |
2002年 | 3049篇 |
2001年 | 2677篇 |
2000年 | 2210篇 |
1999年 | 1760篇 |
1998年 | 1453篇 |
1997年 | 1212篇 |
1996年 | 1019篇 |
1995年 | 920篇 |
1994年 | 721篇 |
1993年 | 558篇 |
1992年 | 490篇 |
1991年 | 452篇 |
1990年 | 382篇 |
1989年 | 333篇 |
1988年 | 322篇 |
1987年 | 279篇 |
1986年 | 216篇 |
1985年 | 258篇 |
1984年 | 223篇 |
1983年 | 165篇 |
1982年 | 164篇 |
1981年 | 163篇 |
1980年 | 129篇 |
1979年 | 121篇 |
1978年 | 65篇 |
1977年 | 42篇 |
1976年 | 49篇 |
1975年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
帕罗西汀合并认知疗法治疗酒依赖伴发抑郁及对戒酒的影响 总被引:1,自引:0,他引:1
目的评价帕罗西汀合并认知疗法治疗酒依赖伴发抑郁的疗效及对戒酒的影响。方法将98例酒依赖伴发抑郁的患者随机分为研究组和对照组,分别用认知疗法合并帕罗西汀、单用帕罗西汀治疗4个月。用汉密顿抑郁量表(HAMD)评定疗效;用复饮率评定戒酒效果。结果治疗1个月后,研究组HAMD评分16.79±6.50与对照组相近17.88±6.59(P>0.05)。治疗4个月后HAMD评分10.76±5.32、明显低于对照组14.54±5.12(P<0.01);临床疗效(痊愈率44.44%、显效率22.22%、有效率33.34%)明显高于对照组(21.74%、21.74%、56.52%)(P<0.05);复饮率(24.44%)低于对照对照组(45.56%)(P<0.05)。结论认知疗法合并帕罗西汀治疗酒依赖伴发抑郁疗效较好,戒酒效果较好。 相似文献
992.
993.
Camil Castelo-Branco Montserrat Rovira Francesca Pons Magdalena Durán Jordi Sierra Angels Vives Juan Balasch Albert Fortuny Juan Vanrell 《Maturitas》1996,23(3):307-312
Long permanent remissions in malignant hematopoietic disorders can often be achieved by autologous bone marrow transplantation (ABMT) or by allogenic bone marrow transplantation (BMT). Previous studies have shown that such therapies may induce osteoporosis due to iatrogenic ovarian failure. The administration of hormone replacement therapy (HRT) in these women could prevent the adverse effects of long-term ovarian failure without remarkable side effects. The aim of this study was to evaluate how the bone mass is affected by HRT in patients undergoing ABMT or BMT adjusting the results for age, weight, and height. Subjects and methods: Thirteen women with previous ABMT/BMT were treated with a standard dose (0.625 mg/day) of conjugated equine estrogen (CEE) or with 50 μg/day of 17-β-estradiol in transdermal therapeutic systems (TTS) plus 5 mg/day of medroxyprogesterone acetate sequentially added to the last 12 days of estrogen therapy. Bone mass was measured prior to and 12 months following HRT. Blood samples were collected before therapy and during the 6th and 12th treatment months. Results: The mean time elapsed between bone transplantation and HRT initiation was 13.0 months (range 3–26 months). Before treatment nine patients were osteopenic and after HRT bone mass increased in all cases. Following ABMT/BMT, hepatic hyperenzymemia was detected in three patients. After 6 and 12 months of treatment no significant changes were observed in hepatic enzymes. Conclusion: Although hepatic hyperenzymemia is commonly considered as a contraindication for HRT, our results suggest that HRT is safe for these patients and that such therapy should be initiated after transplantation in women to prevent adverse effects of long-term ovarian failure. 相似文献
994.
Ethical considerations for enzyme replacement therapy in neuronopathic Gaucher disease 总被引:1,自引:0,他引:1
Elstein D, Abrahamov A, Zimran A. Ethical considerations for enzyme replacement therapy in neuronopathic Gaucher disease. Clin Genet 1998: 54: 179–184. 0 Munksgaard, 1998
Enzyme replacement therapy for Gaucher diseases, the most prevalent lysosmal storage disease, was originally approved by the FDA for type I patients and has proven to be both safe and effective in reducing hepatosplenomegaly and improving the hematological parameters. However, the use of enzyme treatment in both neuronopathic forms has heretofore been on an investigational or trial basis, with reports of progression of neurological deterioration even at very high doses. To date, there are no guidelines for clinicians with regard to enzyme replacement therapy in the neuronopathic forms of metabolic diseases. Herein, we discuss strategies derived from the literature ub-his treatment of very premature babies and from the Jewish Halachic point of view. In conclusion, we describe recommendations for the ethical treatment and/or withdrawal of treatment. as well as practical guidelines for dosage regimens, in children with neuronopathic Gaucher disease. 相似文献
Enzyme replacement therapy for Gaucher diseases, the most prevalent lysosmal storage disease, was originally approved by the FDA for type I patients and has proven to be both safe and effective in reducing hepatosplenomegaly and improving the hematological parameters. However, the use of enzyme treatment in both neuronopathic forms has heretofore been on an investigational or trial basis, with reports of progression of neurological deterioration even at very high doses. To date, there are no guidelines for clinicians with regard to enzyme replacement therapy in the neuronopathic forms of metabolic diseases. Herein, we discuss strategies derived from the literature ub-his treatment of very premature babies and from the Jewish Halachic point of view. In conclusion, we describe recommendations for the ethical treatment and/or withdrawal of treatment. as well as practical guidelines for dosage regimens, in children with neuronopathic Gaucher disease. 相似文献
995.
将小鼠粒细胞-巨噬细胞集落刺激因子(GM-CSF)基因经过同源重组得到表达GM-CSF的重组痘苗病毒,用此痘苗病毒转染小鼠黑色素瘤细胞,制备黑色素瘤瘤苗裂解物(GM-CSFVMO),C57BL/6小鼠皮下接种B16-F10细胞3天后在注射部位注射瘤苗裂解物,一周后再注射一次。结果发现GM-CSFVMO能够显著地抑制荷瘤小鼠肿瘤结节的生长并明显延长荷瘤小鼠的存活期。用此瘤苗裂解物免疫小鼠两次,间隔一周,免疫一周后给C57BL/6小鼠皮下接种B16-F10细胞,结果肿瘤结节出现时间明显延长,部分小鼠肿瘤不再生长。经GM-CSFVMO治疗或免疫后小鼠的外周血和脾淋巴细胞对肿瘤细胞杀伤活性明显升高,NK活性变化不明显。本结果提示,诱导机体特异性细胞免疫可能是瘤苗裂解物的抗肿瘤作用机理之一。 相似文献
996.
目的 总结143例晚期喉癌患者的临床特征,分析预后的影响因素。方法 回顾性分析2010年1月-2016年12月经中国人民解放军总医院治疗的143例晚期喉癌患者的临床资料。其中,男135例(94.4%),女8例(5.6%);年龄35~79岁,中位年龄58岁。依据患者治疗方案不同分为2组:手术联合术后放化疗组106例和非手术综合治疗组37例。收集患者基本临床情况、治疗、随访及生存情况;生存率及单因素生存分析采用Kaplan-Meier法和log-rank检验,多因素生存分析采用Cox比例风险回归模型。结果 143例晚期喉癌患者的5年总体生存率为67.9%。单因素分析显示,影响晚期喉癌患者预后的临床因素有年龄、临床分期、T分期及肿瘤分化程度等(P值均<0.05);Cox模型多因素分析显示,患者年龄、临床分期、肿瘤分化程度及治疗方式是影响预后的独立危险因素(P值均<0.05)。T4期、临床Ⅳ期患者采用手术联合术后放化疗5年生存率分别为62.2%和59.5%,明显好于非手术综合治疗的18.2%和41.4%,差异均有统计学意义(P值均<0.05)。结论 晚期喉癌患者预后相对较差,影响患者预后的因素包括患者年龄、临床分期、肿瘤分化程度及治疗方式等。对于临床Ⅳ期、尤其是T4期患者,采取手术联合术后放化疗可以获得相对较好的预后。 相似文献
997.
Daniel P. Potaczek Sebastian D. Unger Nan Zhang Styliani Taka Sven Michel Nesibe Akdağ Feng Lan Markus Helfer Christoph Hudemann Markus Eickmann Chrysanthi Skevaki Spyridon Megremis Anne Sadewasser Bilal Alashkar Alhamwe Fahd Alhamdan Mübeccel Akdis Michael R. Edwards Sebastian L. Johnston Harald Renz 《The Journal of allergy and clinical immunology》2019,143(4):1403-1415
998.
Vicente AC Agwale SM Otsuki K Njouku OM Jelpe D Idoko JA Caride E Brindeiro RM Tanuri A 《Virus genes》2001,22(2):181-186
In Nigeria, the most populous country in Africa, the characterization of HIV-1 strains has been limited. In this study we evaluated the genetic diversity of the protease coding region, one of the anti-retroviral therapy target, and investigated the presence of mutations related to resistance to HIV protease inhibitors. We analyzed samples collected during 1996 and all patients were anti-retroviral drug na¨ves. Ten samples were evaluated by sequencing of the protease gene. The majority, 80%, were classified as subtype A and the two others were unclassified-divergent strains, something in between A and G subtypes. The gag region from these outliners were sequenced and the phylogenetic analysis classified them as subtype G. The protease amino acid consensus sequence of the Nigerian subtype A are in complete agreement with the consensus A differing from the USA subtype B consensus in 10 positions (L10V, I13V, K14R, I15V, K20I, M36I, R41K, P63L, H69K and L89M).The secondary substitutions associated with protease inhibitor resistance were observed in all Nigerian sequences at the positions L10V, M36I and L89M. The majority of sequence variation was concentrated in the interval between aminoacids 70–90 where the protease substrate binding region is located. 相似文献
999.
认知疗法治疗强迫症的对照研究 总被引:2,自引:0,他引:2
目的 探讨认知疗法治疗强迫症的疗效。方法 对 6 0例符合 CCMD-2 -R诊断标准 ,且 Y-BOCS量表评分≥ 1 6分的强迫症病人 ,随机分到认知治疗组 ( 30例 )和氯丙咪嗪组 ( 30例 ) ,两组在氯丙咪嗪常规治疗的同时 ,其中一组加用认知治疗 ,共治疗 8周。在治疗前、后两组均进行临床疗效评估和 Y-BOCS量表评分。结果 认知治疗组痊愈 1 1例、显效 1 6例、有效 3例。氯丙咪嗪组痊愈 6例、显效 1 4例、有效 1 0例。两组痊愈和显效比较有显著差异 ( P<0 .0 5 )。 Y-BOCS量表减分率 :认知治疗组 5 4 .90 % ,氯丙咪嗪组 4 2 .33% ,两组比较有显著差异 ( P<0 .0 5 )。结论 认知疗法配合药物治疗强迫症比单用氯丙咪嗪治疗强迫症疗效更好 相似文献
1000.
H. H. Hennemann W. Wundt R. Schuh B. Bauer 《Journal of molecular medicine (Berlin, Germany)》1986,64(11):512-517
Summary Acute leukaemia was complicated by pneumonia in 38 (34.8%) of 109 patients treated between 1979 and 1983; in 39.5% of the patients pneumonia occurred more than once. In 23 patients (60.5%) pneumonia occurred during cytostatic therapy, and 25 patients (65.8%) had less than 1000 mm2 granulocytes. Antibiotic therapy had no or only little effect in 70%. A total of 21 patients (55.3%) died of pneumonia. In 15 patients a direct relationship could be seen between pneumonia and the bacterial spectrum in the sputum. A prevalence of gram-negative bacteria was found (24 of 40 bacteria isolated, especially Enterobacteriaceae (19). Fungi were cultivated in 10 cases. Each of the typical pneumonia bacteria was only seen once respectively. It is most important that therapy begin immediately, even before the bacteria have been identified. Only then is there hope that the survival time of patients with acute leukaemia can be influenced. 相似文献