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Development and characterization of DNAzyme candidates demonstrating significant efficiency against human rhinoviruses
Authors:Daniel P Potaczek  Sebastian D Unger  Nan Zhang  Styliani Taka  Sven Michel  Nesibe Akdağ  Feng Lan  Markus Helfer  Christoph Hudemann  Markus Eickmann  Chrysanthi Skevaki  Spyridon Megremis  Anne Sadewasser  Bilal Alashkar Alhamwe  Fahd Alhamdan  Mübeccel Akdis  Michael R Edwards  Sebastian L Johnston  Harald Renz
Institution:1. Institute of Laboratory Medicine, member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), and the inVIVO Planetary Health, Group of the Worldwide Universities Network (WUN), Marburg, Germany;7. Institute of Virology, Philipps-University Marburg, Marburg, Germany;2. PreDicta Consortium;3. John Paul II Hospital, Krakow, Poland;4. Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium;5. Allergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece;6. Secarna Pharmaceuticals GmbH, Planegg, Germany;8. Division of Infection, Inflammation and Respiratory Medicine, University of Manchester, London, United Kingdom;9. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland;10. Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland;11. Airway Disease Infection Section, National Heart and Lung Institute (NHLI), Imperial College London, London, United Kingdom;12. Medical Research Council (MRC) and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
Abstract:
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  • Keywords:Allergy  antisense  antiviral  asthma  atopy  DNAzyme  exacerbation  human rhinovirus  RNA  therapy  ALI  Air-liquid interface  COPD  Chronic obstructive pulmonary disease  CRE  Cis-acting replication element  CRSwNP  Chronic rhinosinusitis with nasal polyps  DMEM  Dulbecco modified Eagle medium  NF-κB  Nuclear factor κB  RV  Human rhinovirus  50% Tissue culture infective dose  TCM  Tissue culture medium  TLR9  Toll-like receptor 9  UTR  Untranslated region
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