相同治法不同配伍对冠心病心绞痛疗效及客观指标的影响

目的 :探讨相同治法不同配伍的中药复方对冠心病心绞痛的临床疗效及客观指标的影响。方法 :采用随机双盲法 ,选取符合入选标准病人 96例 ,随机分为血府逐瘀汤原方组 ;精制血府逐瘀组 ;药对配伍组进行药物干预。结果 :①冠心病心绞痛疗效依次为血府逐瘀组 ,精制血府逐瘀组 ,药对组 (P <0 0 5 ) ;血瘀气滞证证候疗效依次为血府逐瘀组 ,精制血府逐瘀组 ,药对组 (P <0 0 5 ) ;②血府逐瘀组全血粘度、血小板粘附、红细胞变形治疗前后经t检验有显著性差异 (P <0 0 1) ;精制血府逐瘀组全血粘度、血小板粘附治疗前后经t检验有显著性差异 (P <0 0 1) ;药对组血小板粘附、血浆粘度治疗前后经t检验有显著性差异 (P <0 0 1)。③ 3组治疗后一氧化氮均升高 ,治疗前后经t检验有显著性差异 (P <0 0 5 ) ,3组间比较无差异 ;3组疗后ET无显著性差异 (P <0 0 5 )。 3组疗后CD6 2P、CD4 1均降低 ,血府逐瘀组、精制血府逐瘀组治疗前后有显著性差异 (P <0 0 5 ) ,药对组治疗前后无显著性差异 (P >0 0 5 )。结论 :相同治法 ,不同配伍的中药复方临床疗效及客观指标的改善出现差异 ,理法方药一致时优于理法方药不一致时。     

甘草及其有效成分的药效学研究进展

查阅近年文献,概述甘草在抗炎、抗病毒、调节心脑血管、抗肿瘤、抗氧化等方面的药理作用及作用机制,为临床有效应用提供依据。     

细毡毛忍冬血清药物化学初步研究

目的：对细毡毛忍冬乙醇提取物进行血清药物化学研究,为筛选确定细毡毛忍冬的药效成分奠定基础。方法：建立细毡毛忍冬乙醇提取物及大鼠含药血清、空白血清的HPLC指纹图谱分析方法;通过比较细毡毛忍冬乙醇提取物、含药血清及空白血清指纹图谱,确定其血清移行成分。结果：在含药血清中发现了8个移行成分,其中2个为原型成分,6个是代谢产物。结论：血中移行成分和代谢产物可能成为细毡毛忍冬的体内直接作用物质,对其更深入的研究有助于探索其药效物质基础及作用机制。     

树鼩乳汁的主要成分检测及其意义-修改稿

目的 探讨树鼩乳汁的基本成份,并和其它乳制品成份进行了比较分析。方法 采用无菌操作的方法,用注射器直接采取2只母树鼩分娩22d后的乳汁,1次/天,连续3天,每只母树鼩采取18ml乳汁,按照国家标准的方法进行成分检测。结果 发现树鼩乳总固形物为44.88％、脂肪为23.66％、蛋白质为8.75％、乳糖为0.47％、灰分为0.73％。与牛乳相比,树鼩乳总固形物、蛋白质和脂肪含量高于牛乳,而乳糖含量低于牛乳。与婴幼儿配方奶粉相比,树鼩乳的蛋白质、乳糖含量低于婴幼儿配方奶粉,而脂肪含量远高于婴幼儿配方奶粉。树鼩乳脂肪含量远高于婴幼儿配方奶粉和牛乳的1.39和6.07倍,乳糖含量远低于婴幼儿配方奶粉和牛乳的14.5和10.4倍。结论 树鼩乳的主要营养成分呈现高脂高蛋白低糖,可为树鼩人工育幼和饲养工作提供依据。     

复方田七跌打软膏治疗急性软组织挫伤的实验研究

目的　观察自产复方田七软膏在动物实验中的疗效。方法　设计软组织挫伤打击器对小白鼠造成人为挫伤的动物实验 ,分 2期通过外表和组织学观察复方田七跌打软膏的消肿、止痛、去瘀的效果。结果　复方田七软膏组的评分较樟脑组和对照组低 ,显示其疗效明显优于其他 2组。结论　复方田七软膏具有明显消肿止痛、活血化瘀作用。     

Marketing dietary supplements in the United States: a review of the requirements for new dietary ingredients

Since the passage of the Dietary Supplement Health and Education Act in 1994, the marketplace for dietary supplements has experienced dramatic growth. New products have redefined the entire marketplace, and new ingredients are introduced to consumers at lightning speed. As part of this act, laws were passed to ensure the safety of new dietary ingredients introduced into the United States marketplace. But more than 11 years later, these laws are frequently misunderstood, and more frequently ignored. This article reviews the regulatory landscape of new dietary ingredients and defines the issues manufacturers must contend with to legally market dietary supplements with new dietary ingredients in the U.S.     

Dissolution characteristics of cylindrical particles and tablets

In this paper, dissolution characteristics of primary-particles and compressed tablets were investigated by experiments using a mathematical model. For the primary-particle, it was found that the dissolution rate increased with a decrease in the particle size. Assuming that primary-particles of size distribution were of cylindrical shape and that the dissolution occurs from the total external surface, an extended Nernst–Noyes–Whitney equation fitted to the experimental data well. As the influences of particle size and shape on thickness of a diffusion-boundary film were found to be quite low, the dissolution rate was considered to be affected by the specific surface area dominantly. Furthermore, the same model was applied to a compressed tablet and fitted to the data well. Though the rate constant obtained were not affected by the properties of primary-particles forming the tablet, it was found to increase with the apparent voidage which occupies the inter-particle volume of tablet diluent among less soluble particles. Consequently, an increase in the apparent voidage is presumed to accelerate penetration of water into the internal voids of the tablet. Thus, the dissolution going, the effective surface area inside the tablet is considered to be extended.     

Patch testing with perfume ingredients

From the large number of substances used in perfumes it is difficult and tedious to identify the allergen in a specific case of dermatitis. Many substances are both irritants and sensitizers. Based on personal experience, a list has been prepared of potential sensitizers, their concentrations and diluents suitable for patch testing.     

缬草的性状与显微鉴别研究

目的:研究缬草的性状及显微鉴别特征。为进一步制定缬草的质量标准及开发利用提供科学依据。方法:利用性状与显微鉴别的方法对其进行药材性状的组织构造及粉末的鉴别。结果:制订和建立了缬草的性状鉴别与显微鉴别的标准。结论:本文章建立的鉴别指标可有效控制缬草的药用质量。     

Characterization of the constituents in rat biological fluids after oral administration of Fufang Danshen tablets by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry method was established to detect as many constituents in rat biological fluids as possible after oral administration of Fufang Danshen tablets (FDTs). A C18 column (1.8 μm particle size) was adopted to separate the samples, and mass spectra were acquired in both negative and positive modes. First, the fingerprints of FDTs were established, resulting in 43 components being detected within 25 min. Among these compounds, 37 were tentatively identified by comparing the retention times and mass spectral data with those of reference standards and the reference literature; the other 6 components were tentatively assigned solely based on the MS data. In vivo, 14 components and 8 metabolites of FDT were observed in plasma, and 12 components of FDT were detected in urine. Tanshinaldehyde, danshexinkun B, a glycine conjugate of danshensu and a methylated conjugate of danshexinkun B were newly detected in rat biological fluids. This study developed a high-speed and sensitive method that was successfully utilized for screening the active ingredients of a Chinese medical formula and provided helpful chemical information for further pharmacology and active mechanism research on Chinese medicine.