| 细毡毛忍冬血清药物化学初步研究 |
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| 引用本文： | 付燕伟,黎豫川,陀扬凌,唐瑜,张旭.细毡毛忍冬血清药物化学初步研究[J].四川省卫生管理干部学院学报,2014(4):7-8. |
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| 作者姓名： | 付燕伟 黎豫川 陀扬凌 唐瑜 张旭 |
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| 作者单位： | 成都中医药大学药学院教育部中药材标准化重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137 |
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| 基金项目： | 四川省教育厅重点项目（2010A036） |
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| 摘 要： | 目的：对细毡毛忍冬乙醇提取物进行血清药物化学研究,为筛选确定细毡毛忍冬的药效成分奠定基础。方法：建立细毡毛忍冬乙醇提取物及大鼠含药血清、空白血清的HPLC指纹图谱分析方法;通过比较细毡毛忍冬乙醇提取物、含药血清及空白血清指纹图谱,确定其血清移行成分。结果：在含药血清中发现了8个移行成分,其中2个为原型成分,6个是代谢产物。结论：血中移行成分和代谢产物可能成为细毡毛忍冬的体内直接作用物质,对其更深入的研究有助于探索其药效物质基础及作用机制。
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| 关 键 词： | 细毡毛忍冬 血清药物化学 移行成分 |
Primary research on serum pharmacochemistry of Lonicera similes Hemsl |
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| FU Yan-wei,LI Yu-chuan,TUO Yang-ling,TANG Yu,ZHANG Xu.Primary research on serum pharmacochemistry of Lonicera similes Hemsl[J].Journal of Sichuan Continuing Education College of Medical Sciences,2014(4):7-8. |
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| Authors: | FU Yan-wei LI Yu-chuan TUO Yang-ling TANG Yu ZHANG Xu |
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| Institution: | Pharmacy College, Chengdu University of Traditional Chinese Medicine; The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine,＂ State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and MOST, Chengdu 61113 7, China) |
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| Abstract: | Objective： To ,screen and identify the medicinal ingredients through the research on serum pharmacochemistry of ethanol extract of Lonicera similes Hemsl. Method：The HPLC fingerprints analytical methods of ethanol extract of Lonicera similes Hemsl. was built up. Serum transitional components were identified through comparing the fingerprints of ethanol extract, rat serum-containing active components and blank serum. Result： 8 transitional ingredients were obtained. Two of them were prototype components, and the others were metabolites. Conclusion： Serum transitional components and the metabolites may be active ingredients that directly work in the body. Further research will be beneficial to explore the material basis of efficacy and action mechanism of Lonicera similes Hemsl. |
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| Keywords: | Lonicera similes Hemsl serum pharmacochemistry transitional ingredients |
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