9th month (P<0.05).There was a significant di

n cognition ability at 9th month too (P<0.05).Conclusion The baby touch that begins at early time after birth may benefit the neurological and psychological development of the infants and has a long-based effect.Baby touch Intelligence development Different phase0中国全科医学Chinese General Practice36-37R174E055;E069;72;2;EE055_72;E069_2;郭建华000900030001;000900030008000200010003;0009000300040015000230-31影响婴儿出生体重的高危因素分析张勇,王燕,朱鹃,范钦颖中日友好医院预防保健科 ,中日友好医院预防保健科 ,中日友好医院预防保健科 ,中日友好医院预防保健科 100029北京市,100029北京市,100029北京市,100029     

SPSS统计软件简介

统计软件(statistical software)是统计方法与计算机相结合的产物,是由统计学家、数学家、电脑专业人员根据统计学理论将各种统计方法用一定的计算机语言编成各种统计分析模块,让计算机去完成统计计算过程的专业软件,它的作用在于代替专家对科研数据进行统计处理。各种统计软件包一般都是由统计学家、数学家、计算机软硬件专家共同设计研制而成,并经过精心调试,严格考察才面市     

The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6 -174GC, IL-8 -251AT and MCP-1 -2518AG in the risk of venous thromboembolism: a case-control study

Introduction

Cytokines increased the risk of venous thromboembolism (VTE) in some case-control studies, but not in a prospective study. Data concerning the role of cytokines in the risk of VTE are limited. We examined in a case-control study the association of VTE and levels of interleukin (IL)-6, IL-8 and monocyte chemotactic protein-1 (MCP-1) and assessed whether promoter polymorphisms (IL-6 -174GC, IL-8 -251AT, MCP-1 -2518AG) would affect the thrombotic risk and cytokine levels.

Materials and methods

The study included 119 patients (94 women) with a first event of VTE aged between 18-60 years, and 126 healthy controls (100 women) matched for age (± 5 years). Blood was collected > 7 months after the thrombotic event. Odds ratios (ORs) were calculated per increase of cytokines levels by 1 pg/mL.

Results

ORs adjusted for age and sex were 1.520 [95% Confidence Interval (CI) 1.177 - 1.962] for IL-6, 1.095 (95% CI 1.002 - 1.196) for IL-8 and 1.000 (0.988 - 1.012) for MCP-1. With additional adjustment for ethnic composition, body mass index (BMI) and high sensitive C-reactive protein (hs-CRP), risk estimates remained significant for IL-6 and became of borderline statistical significance for IL-8. Polymorphisms did not influence the thrombotic risk and the cytokine levels in study participants.

Conclusion

VTE was associated with IL-6 and IL-8 levels, and for IL-6 this association was independent of BMI and hs-CRP. Thus far, a causal relationship between inflammation and VTE remains to be clarified and more prospective data are warranted.     

随机区组设计资料的方差分析

本研究以随机区组设计资料的方差分析为例,给出在SPSS中的完整的统计分析步骤。其中以残差的正态性检验来代替各单元格的正态性检验,从而解决由于样本量太小而无法进行正态性检验的问题。     

Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology

Mescaline and phencyclidine (PCP) are potent hallucinogenic agents affecting human and animal behavior. As their psychotropic effects remain poorly understood, further research is necessary to characterize phenotypes they evoke in various animal models. Zebrafish (Danio rerio) are rapidly emerging as a new model organism for neuroscience research. Here, we examine the effects of mescaline (5-20mg/l) and PCP (0.5-3mg/l) in several zebrafish paradigms, including the novel tank, open field and shoaling tests. Mescaline and PCP dose-dependently increased top activity in the novel tank test, also reducing immobility and disrupting the patterning of zebrafish swimming, as assessed by ethograms. PCP, but not mescaline, evoked circling behavior in the open field test. At the highest doses tested, mescaline markedly increased, while PCP did not affect, zebrafish shoaling behavior. Finally, 20mg/l mescaline did not alter, and 3mg/l PCP elevated, whole-body cortisol levels. Overall, our studies indicate high sensitivity of zebrafish models to hallucinogenic compounds with complex behavioral and physiological effects.     

The utility of DW-MRI in the diagnosis of pancreatic focal lesions

Background

Early diagnosis is crucial in management of pancreatic malignancy. DWMRI could be used in differentiating pancreatic lesions and judge about tumor aggressiveness.

香丹注射液中重金属的质量控制及评价

目的：建立电感耦合等离子体质谱（ICP-MS）法,测定香丹注射液中的铅（Pb）、 镉（Cd）、砷（As）、汞（Hg）、铜（Cu）。方法：分别以锗（Ge）、铟（In）、（Bi）为内标,采用ICP-MS 法同时测定5种元素的残留量;采用SPSS统计分析软件对不同厂家各批次之间及相同厂家不同批次之间的样品进行统计分析与评价。结果：所测元素标准曲线的相关系数均r>0.999,平均回收率为104%～122%,相对标准偏差（RSD）<7.9%。Cd和Pb的含量呈显著正相关性,Pearson相关系数为0.880;另外As和Pb、As和Cd的含量也有一定的相关性,Pearson相关系数分别为0.623和0.587。以上统计结果P值均小于0.05（具有显著性意义）。结论：该方法准确、快速、简便,可用于香丹注射液中重金属及有害元素的质量控制,也为横向评价各厂家生产的该药品质量提供辅助性参考。     

基于SPSS的共现聚类分析参数选择的实例研究

以OHSUMED语料库内提供的明确相关提问对为金标准和研究材料,借助BICOMB软件生成主题词-来源文献矩阵和共词矩阵,并获得各种系数的相似（相异）矩阵,对比分析目前国内基于SPSS共现聚类分析过程中主题词-来源文献矩阵与共现矩阵、各种相似性参数和各种类间距离计算方法的聚类效果。结果表明：主题词-来源文献矩阵聚类结果优于共词矩阵,在聚类分析中应优先选择。共词矩阵选择相似系数时应结合实际矩阵数据性质,并注意聚类方法原理上的正确性。     

作者合著网络节点重要性评价指标的属性

选取2014年JCR中肿瘤学领域影响因子最高的3种期刊Ca-A Cancer Journal For Clinicians,Nature Reviews Cancer和Lancet Oncology为数据来源,利用书目共现分析系统BICOMB对3种期刊的文献数据进行共现分析,运用整体网络分析工具UCINET绘制肿瘤学研究领域的作者合著网络,运用SPSS分析作者发文量,被引量与合著网络节点重要性的评价指标（点度中心度、中间中心度、接近中心度和特征向量）之间的相关性,以此发现作者合著网络节点重要性指标的具体评价意义。