Interparietal hernia mimicking malignant small bowel obstruction

Summary Interparietal hernias are rare but in most cases should not present any particular difficulty with diagnosis or subsequent management. However, in difficult cases magnetic resonance imaging may prove to be the most useful investigation in the future. In this case report we described such a hernia in an adult, which was provisionally diagnosed as a caecal carcinoma.     

甘肃省1999年上半年性病疫情报告及漏报情况调查分析

目的 查明我省今年上半年性病疫情下降的主要原因。方法 对全省14个地、州和市所在地的部分医疗机构1999年上半年的性病疫情报告情况进行调查,计算漏报率。结果 调查83所医疗机构,查出病例4 647例,报告病例924例,漏报病例3 723例,漏报率为80.11％,报告病例数与查出病例数比为1:5。结论 我省1999年上半年STD疫情下降的主要原四是性病疫情报告率非常低,漏报率极高。     

隐蔽分组(分配隐藏)和盲法的概念、实施与报告

“分配隐藏”很容易被误解而被广大临床试验实施者和论文作者所忽略,尤其是常将“分配隐藏”与盲法混淆。分配隐藏实质是产生随机序列者和决定分配序别者不能参与纳入受试者,也不宜参与以后的试验过程,尤其不能参与结果的测量。本文通过实例介绍了正确的分配隐藏和盲法实施过程。最后,还举例介绍了论文写作中方法学的描述。     

反基因寡核苷酸抑制内皮细胞组织因子表达的体外研究

目的：探讨形成三股螺旋的寡核苷酸(triple helix-forming oligonucleotide，TFO)对内皮细胞组织因子(tissue factor，TF)基因表达的抑制作用。方法：将针对TF基因启动子区的3个Spl/Egr-1位点合成的TFO，与含有人TF基因5’上游序列-244/ 122bp的荧光素酶报告基因质粒PL37，经脂质体转染内皮细胞，接受12dyn/cm^2切应力作用后，检测及分析报告基因活性。结果：反向硫代磷酸酯TFO(antiprarallel-phosphorothioated TFO，apTFO)显抑制荧光素酶表达．抑制率高达70.3％。结论：apTFO能有效抑制切应力诱导的TF基因表达。     

Impact of adolescent peer aggression on later educational and employment outcomes in an Australian cohort

This study used prospective birth cohort data to analyse the relationship between peer aggression at 14 years of age and educational and employment outcomes at 17 years (N = 1091) and 20 years (N = 1003). Participants from the Western Australian Pregnancy Cohort (Raine) study were divided into mutually exclusive categories of peer aggression. Involvement in peer aggression was reported by 40.2% (10.1% victims; 21.4% perpetrators; 8.7% victim–perpetrators) of participants. Participants involved in any form of peer aggression were less likely to complete secondary school. Perpetrators and victim–perpetrators of peer aggression were more likely to be in the ‘No Education, Employment or Training’ group at 20 years of age. This association was explained by non-completion of secondary school. These findings demonstrate a robust association between involvement in peer aggression and non-completion of secondary school, which in turn was associated with an increased risk of poor educational and employment outcomes in early adulthood.     

第二届北京国际自身免疫性肝病专题研讨会议纪要

@@     

170例药品不良反应报告分析

目的：了解汕头大学医学院第二附属医院（以下简称“我院”）药品不良反应（ adverse drug reaction,ADR）发生的特点及规律,为进一步完善ADR监测工作提供参考。方法：对我院2013年收集的170例ADR报告进行回顾性分析。结果：引起ADR的药物剂型主要为注射剂,共161例（占94．71％）;抗菌药物引起的ADR最多,共71例（占41．76％）,其次为抗肿瘤药,共21例（占12．35％）。结论：应加强ADR的监测与报告,提高医务人员对ADR的重视,以减少ADR的发生,保障患者用药安全。     

广州市2005-2008年丙型肝炎疫情分析

丙型肝炎病毒(HCV)感染是一个易被忽视的社会公众问题.HCV感染慢性化程度高,可发展为肝硬化及肝癌~([1]).目前丙型肝炎已有特效的药物治疗,如能及早治疗,可防止其发展为肝硬化和肝癌~([2-3]).     

Hyperthyroidism in Two Patients with Crohn Disease and Takayasu Arteritis

Thyroid abnormalities and Takayasu arteritis (TA) have been reported separately in patients with Crohn disease (CD). We report two patients with hyperthyroidism, CD and Takayasu arteritis and discuss hypothetical mechanisms. Case 1. A thyrotoxic goiter was diagnosed in 1987 in a 34-year-old woman treated since 1969 for severe CD and TA. Iodine urinary excretion was 405 &#114 &#55 g/mL (20-500). Anti-thyrotropin receptor (TRAK) and anti-thyroid antibodies were not detectable. The ultrasonography showed a nodule in the right lobe of the thyroid and two nodules in the left lobe. A 123 I thyroid scan showed a multinodular goiter with no hot nodule. She was treated successfully with propylthiouracile until 1991, when a new episode of thyrotoxicosis led to a subtotal thyroidectomy. Case 2. Hyperthyroidism was diagnosed in February 2000 in a 49-year-old woman treated for CD and TA, both diagnosed in 1980. TRAK and anti-thyroid peroxydase antibodies were not detectable. The ultrasonography disclosed a normal thyroid volume with an inhomogeneous parenchymal structure and nodular images in both lobes. A 123 I thyroid scan showed one hot nodule in the lower part of each lobe. A subtotal thyroidectomy was performed. The association of these three diseases may not be fortuitous, possibly explained by genetic predisposing factors and disease-related iodine deficiency both involving Nuclear Factor &#51 B pathway.