Peyronie’s disease may negatively impact the sexual experience of a couple and female sexual function: a single center study

BackgroundPeyonie’s disease (PD) mostly affects males in the fifth decade of life, with a prevalence in the general population ranging between 0.5% and 20.3%. The pathology of PD is characterized by fibrosis of the tunic albuginea of the cavernous bodies of the penis, with the presence of pain in the erection and penile deformity. This is associated with decreased sexual function for both participants. The objective of the study was to investigate the influence of PD pathology on both male patients’ and their female partners’ sexual spheres, and analyze changes in sexual function and perception following penile correction surgery.MethodsProspective study, we included male patients with PD and their female partner sexually active. Patients underwent corporoplasty with multiple plications. The male and female sexuality was evaluated before surgery and three months after male treatment by the Female sexual Function Index (FSFI); International Index of Erectile Function (IIEF); Visual Analogical Scale (VAS).ResultsFrom January 2018 to November 2019 we included 35 couple. The female subjects before partner’s surgery presented dyspareunia, loss of sexual desire, inability to achieve orgasm, and sexual dissatisfaction. At three months after surgical treatment there was an improvement of sexual function in both male patients and female partners (desire P<0.0001, arousal P<0.0001, lubrification P<0.0001, orgasm P<0.0001, satisfaction P<0.0001, pain P<0.0001). As regarding male patients the pain decreased significantly (VAS score from 6 to 2.5), while there was no statistically significant improvement in erectile function (P=0.05).ConclusionsOur findings suggest that a viable approach to treatment of PD patients that involves their partners could lead to better functional and psychological results.     

A novel mis-sense mutation (G1381A) in the G6PD gene identified in a Chinese man

Objective　To detect new mutations among 29 glucose-6-phosphate dehydrogenase (G6PD) deficient individuals from Yunnan province. Methods　The nitroblue tetrazolium (NBT) method was used to screen G6PD deficient individuals. Mutation was identified by single strand conformation polymorphism (SSCP), amplification created restriction site (ACRS), amplification refractory mutation system (ARMS) and DNA sequencing. Results　Among 29 cases, 18 cases of G1388A, 1 case of C1004A, and 1 case of G1381A were identified. Nine cases remained to be defined. The G1381A mutation is a novel mis-sense mutation, with a substitution of threonine for alanine (A461T). The resultant G6PD had reduced enzymatic activity. In addition, G1381A caused a restriction site of Stu I to disappear, providing a rapid method for the detection of this mutation. Conclusion　A novel mis-sense mutation G1381A was found. This mutation results in a substitution of threonine for alanine, producing enzyme with reduced activity. The loss of the Stu I restriction site offers a rapid method for the detection of this mutation.     

银杏叶提取物在MPTP神经毒中的抗氧化作用

目的 观察银杏叶提取物（Ginkgo biloba leaves EGb)在1－甲基－4－苯基－1,2,3,6－四氢吡啶（1－methyl-4-phenyl-1,2,3,6-tetrahyropyridine,MPTP)神经毒中的抗氧化作用。方法 采用大脑立体定位仪向黑质内注射MPTP,腹腔注射EGb连续20d,测定大鼠相关脑区中丙二醛（malondiadehyde,MDA)、超氧化物歧化酶（superoxide dismutase,SOD)含量的变化。结果 MPTP使黑质中的MDA增高,SOD降低;EGb对此有明显的抑制作用。结论 EGb在MPTP神经毒中有明显的抗氧化作用。     

pH电极位置对反流性食管炎酸监测的影响

为探讨ｐＨ电极位置对反流性食管炎酸监测的影响,将６０例反流性食管炎随机分为对照（Ｃ）组和试验（Ｔ）组。 Ｃ组 ３０例用测压法将 ｐＨ电极置于下食管括约肌（ＬＥＳ）上缘 ５ ｃｍ处;Ｔ组 ３０例用 ｐＨ梯度法将电极放于胃食管连接处（ＧＥＪ）上方 ５ ｃｍ处。连续 ２４ ｈ ｐＨ监测。结果显示,Ｃ与Ｔ组前鼻孔至ＧＥＪ平均距离分别为（４６． ２±４．１） ｃｍ与（４６． ５±４． ５） ｃｍ,两者无明显差异（Ｐ＝０． ８）。两组前鼻孔至ＧＥＪ平均距离（４６． ３±４． ３） ｃｍ比 Ｃ组前鼻孔至ＬＥＳ上缘平均距离（４３． ３±３． １） ｃｍ低 ３． ０ ｃｍ（Ｐ＝０． ０００３）。食管酸监测的 ｐＨ＜４,总百分时间和总计分在Ｔ组（８．５和 ４５． ５）和Ｔ组中ＧＥＪ＞ＬＥＳ上缘＋３ ｃｍ和＜－３ｃｍ范围者（１０． ０和 ９９． ３）较Ｃ组（４． ８和 ２６． ３）均有明显增高, Ｐ均＜０． ０１）,而Ｔ组中ＧＥＪ≤ＬＥＳ上缘＋３ ｃｍ和≥－３ ｃｍ范围者（７． １和 ３９． ４）则无明显差异（ Ｐ均＞０． ０５）。研究结果表明,因 ＧＥＪ常比 ＬＥＳ上缘偏低,故以 ＧＥＪ安放电极（尤其是ＧＥＪ＞ＬＥＳ上缘 ＋ ３ｃｍ或＜－ ３ｃｍ范围者）对反流性食管炎行 ｐＨ监测时     

Comparison of the precision of two standardized co-ordinate systems for the quantitation of brain anatomy: preliminary results

We assessed reproducible definition of two standardized co-ordinate systems for intersubject analysis of brain images. The baselines in the two co-ordinate systems were a modification of the canthomeatal (inCM) line and the anterior-posterior commissural )AC-PC) line. Axial spin-echo MR images of four subjects at 1.5T were used. Operator error was computed from the replicate analyses of two operators. The mCM line was determined by the lens of the eye and the internal auditory canal, and the AC-PC line was determined by the intersection of the AC and PC with the interhemispheric fissure. Reproducibility of the mCM markers (SD=0.59 mm) did not differ significantly from that of the AC-PC line (SD=0.68 mm). The measurement error of the angle of the baseline (), however, was more than 7 times as large for the AC-PC line as for the mCM line. An additional error affecting the rostrocaudal rotation of the co-ordinate systems, attributable to the distance between the anatomic markers, was 2.1 and 3.6° (3 mm and 5 mm slice thickness) for the mCM co-ordinate system and 8.2 and 11.0° (3 mm and 5 mm slice thickness) for the AC-PC system. The AC-PC line based co-ordinate system is therefore, less reproducible than the mCM line based system. this could be improved if a combination of axial and sagittal images were used for the definition of the AC-PC line.     

长期饮酒对男性生殖系统功能影响

目的探讨饮酒对男性生殖系统的损害及其机理。方法选择45名男性饮酒者和9名慢性酒精中毒者为研究对象,以15名不吸烟不接触毒物的男性为对照组。结果长期大量饮酒和酒精中毒者血清中T和CS水平下降,而LH和FSH水平升高;精浆和精子中LDH,LDH-x和G-6PD活力下降,以LDH-x下降为敏感;精子数量和活动精子年均降低,精子畸形率及异常精液检出率均升高。上述各指标与对照组比较差异均有高度显著性（P＜0.01）。结论长期饮酒可损害男性生殖系统功能。     

Retrograde intubation dacryocystorhinostomy for proximal and midcanalicular obstruction

Objective

Retrograde intubation of canaliculi during dacryocystorhinostomy can restore canalicular patency in cases otherwise managed with bypass tubes. The surgical technique and success for this procedure are discussed.

A new model for non-invasive,reproducible fixation of a stereotaxic frame using an orthodontic resin plate

Summary The authors describe a new method for reproducible, non-invasive fixation of a stereotaxic localizing frame. A localizing system similar to that of Brown-Roberts-Wells for MR can be fixed at the base of the facial skeleton to the upper dental arch by an orthodontic resin plate. Results of trials with CT scan, advantages and disadvantages are discussed.The new fixture could be employed in open surgery and in fractionated radiotherapy.     

Comparative patterns of i-antigen expression, F-cell frequency and Hb A2 level in acute myeloid leukemia and in acute lymphoid leukemia

Hb F, Hb A₂ and i-antigen expression were investigated in adulthood acute leukemias. The study of i-antigen expression by immuno-agglutination and immunofluorescence showed that it is preferentially increased among AML patients. A similar result was obtained for F-cell frequency which was often increased in AML, while it was normal in ALL. Hb A₂ level was significantly lower in AML than in ALL. These differences between AML and ALL red cell patterns further suggest that the leukemic clone involves the erythroid lineage in AML but not in ALL.     

成年男性额面颈部红外热像的定位定量研究

目的:探索人体红外辐射(IRR)的表达规律。方法:应用国产DW—9100医用红外热像仪,采集成年男性额、面、颈部IRI,IRIAS专用软件自动定位、定量,Excel 统计学处理。结果:成年男性额、面、颈部IRI有效色码表达可达11级,色码分布具有明显的定位规律;Ⅰ～Ⅺ级色码温区呈递减状态,同级色码平均温差为1.03℃,P<0.01; 逐级色码平均递减温差为1.05℃,P<0.01 ,均有显著差异。不同年龄的色码温差亦有显著差异。结论:人体额面颈部IRR具有明显的定位、定量规律。有助于进一步探索人体IRR表达的多元信息。