全文获取类型
收费全文 | 2071篇 |
免费 | 98篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 110篇 |
妇产科学 | 157篇 |
基础医学 | 276篇 |
口腔科学 | 146篇 |
临床医学 | 123篇 |
内科学 | 386篇 |
皮肤病学 | 24篇 |
神经病学 | 225篇 |
特种医学 | 48篇 |
外科学 | 265篇 |
综合类 | 5篇 |
预防医学 | 82篇 |
眼科学 | 29篇 |
药学 | 132篇 |
中国医学 | 5篇 |
肿瘤学 | 162篇 |
出版年
2023年 | 13篇 |
2022年 | 3篇 |
2021年 | 60篇 |
2020年 | 33篇 |
2019年 | 37篇 |
2018年 | 51篇 |
2017年 | 38篇 |
2016年 | 47篇 |
2015年 | 47篇 |
2014年 | 81篇 |
2013年 | 104篇 |
2012年 | 156篇 |
2011年 | 166篇 |
2010年 | 75篇 |
2009年 | 85篇 |
2008年 | 112篇 |
2007年 | 137篇 |
2006年 | 124篇 |
2005年 | 133篇 |
2004年 | 119篇 |
2003年 | 95篇 |
2002年 | 99篇 |
2001年 | 27篇 |
2000年 | 29篇 |
1999年 | 39篇 |
1998年 | 12篇 |
1997年 | 10篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 11篇 |
1993年 | 17篇 |
1992年 | 20篇 |
1991年 | 24篇 |
1990年 | 19篇 |
1989年 | 14篇 |
1988年 | 17篇 |
1987年 | 12篇 |
1986年 | 7篇 |
1985年 | 13篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1981年 | 10篇 |
1980年 | 5篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1974年 | 4篇 |
1973年 | 6篇 |
1967年 | 2篇 |
排序方式: 共有2181条查询结果,搜索用时 15 毫秒
1.
Maria Rinzivillo Ilaria De Felice Ludovica Magi Bruno Annibale Francesco Panzuto 《Journal of gastrointestinal oncology.》2021,12(2):845
BackgroundIn the last decades, the incidence of neuroendocrine neoplasia (NEN) increased from 1 to 5 new diagnoses/100,000 persons/year. The synthetic somatostatin analogues (SSAs) represent the first-choice treatment for both functionally active and inactive gastro-enteric-pancreatic NEN. This systematic review examines the role of octreotide long-acting release (LAR) in combination with other therapies for NEN management.MethodsPrimary outcomes were the disease control rate and the progression free survival (PFS), defined as the time between treatment initiation and progression of disease. Secondary outcomes were overall survival (OS) and safety.ResultsThis systematic review identified 13 studies, concerning the use of octreotide LAR in association with other therapies in advanced NENs and included 1,206 patients. Patients were treated with octreotide LAR in combination with other drugs, mainly with everolimus (404 patients, 35%), but even with Peptide Receptor Radionuclide Therapy, bevacizumab, interferon or fluoride-derivatives. Disease control was observed in 85% cases with SSAs in combination with other therapies; PFS ranged from 15 to 16.4 months and OS from 25 to 61.9 months. SSAs are very well tolerated drugs, with few side effects which are usually mild, not requiring drug withdrawn.ConclusionsThe review summarizes the effectiveness and available safety data on octreotide LAR in combination with other therapies in patients with NEN and may provide suggestions to address the therapeutic strategy. Further comparative head-to-head studies are needed to understand which is the best combination treatment for patients with progressive NEN after failure of first-line therapy. 相似文献
2.
Wojciech Szychta M.D. Ph.D. Gheorghe Cerin M.D. Ph.D. F.E.S.C. Bogdan Adrian Popa M.D. Armienti Felice M.D. Guido Lanzillo M.D. Ph.D. Marco Diena M.D. Grzegorz Opolski M.D. Ph.D. F.E.S.C. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(6):1040-1043
Sinus venosus atrial septal defect (SV‐ASD) usually coexists with partial anomalous pulmonary vein connection (PAPVC). It is a difficult diagnosis in transthoracic echocardiography (TTE) due to eccentric position of defects. We present a rare case of atypical anatomical variation in PAPVC, which was never described before. Two right pulmonary veins drained into superior vena cava, which overrode SV‐ASD and interatrial septum, a third pulmonary vein into the right atrium. Complete diagnosis could not be set after TTE, nor transesophageal echocardiography, whereas angio‐CT was finally conclusive. This diagnostic approach allowed the surgical planning. 相似文献
3.
4.
F. Murina R. Felice S. Di Francesco L. Nelvastellio I. Cetin 《Gynecological endocrinology》2020,36(5):431-435
AbstractThis study is a single-center, retrospective analysis of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60?mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene?+?laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene?+?laser group compared with the laser treatment group (?87% vs???34%, respectively), and the vestibular health score started declining faster in the ospemifene?+?laser group. Although, additional research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clinical effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause. 相似文献
5.
6.
Papa F Cortese A Maltarello MC Sagliocco R Felice P Claudio PP 《The British journal of oral & maxillofacial surgery》2005,43(4):309-313
We report 50 patients who had sinus lift operations between 1995 and 1999 using different grafting materials [autologous bone, heterologous bone, and hydroxyapatite]. The casenote were analysed clinically (intraoperative and postoperative results and complications), radiographically (amount of augmented bone 6 months postoperatively), and histologically (quality of the new bone 12 months postoperatively). Our aim was to find out if the various bone grafting materials used resulted in different outcomes after adjustment for significant predictors. We found that hydroxyapatite was associated with the lowest rate of loss of grafted material (median, 2.4 mm) followed by the autologous bone from iliac crest (2.8 mm). Bovine bone shown the highest loss (3.3 mm). 相似文献
7.
Femiano F Scully C Gombos F 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2003,95(2):169-173
A 68-year-old female patient treated with benazepril for arterial hypertension developed oral and cutaneous blistering. Biopsy of the oral and cutaneous lesions showed neutrophilic microabscesses in the mesenchymal papillae, with epitheliomesenchymal separation. Direct immunofluorescence revealed linear immunoglobulin deposits at the epithelial basement membrane zone, consisting predominantly of IgA. The histologic results supported the clinical diagnosis of drug-induced linear IgA disease. The substitution of benazepril with a beta blocker resulted in complete resolution of all mucocutaneous lesions. 相似文献
8.
Ciuffolo F Manzoli L D'Attilio M Tecco S Muratore F Festa F Romano F 《European journal of orthodontics》2005,27(6):601-606
The aim of this study was to describe the prevalence and distribution, by gender, of occlusal traits in a sample of Italian students aged 11-14 years (mean 13 +/- 1 years). Using standardized and validated recording criteria, a single operator measured the overjet, overbite, open bite, anterior and posterior crossbites, crowding, coincidence of the upper and lower midlines, and diastema, in 810 secondary school students (53.6 per cent males). Chi-square, t-test statistics, and odds ratios (ORs) with 95 per cent confidence intervals (CI) were used to investigate the relationship between gender and malocclusion characteristic. Logistic regression was used to further analyse the independent association between gender and each outcome measure. Ninety-three per cent of the subjects showed at least one occlusal trait, with one or two anomalies recorded in 63 per cent of children. The prevalence of occlusal traits ranged from 1.1 (negative overjet) to 54 per cent (upper and lower midlines not coincident). Males were more likely than females to show both an increased overbite and an increased overjet, although the latter result was not confirmed by logistic regression (P = 0.05). Multivariate analysis showed a negative association between overbite and misalignment of the lower incisors and lack of coincidence of the upper and lower midlines, whereas subjects with an increased overbite were more likely to have an increased overjet (all P < 0.01). Further studies are required in order to further clarify these findings and to provide accurate estimates of the orthodontic treatment need in Italian adolescents. 相似文献
9.
Tecco S Festa F Caputi S Traini T Di Iorio D D'Attilio M 《The Angle orthodontist》2005,75(6):1041-1045
The friction generated by various bracket-archwire combinations previously has been studied using in vitro testing models that included only one or three brackets. This study was performed using a specially designed apparatus that included 10 aligned brackets to compare the frictional resistance generated by conventional stainless steel brackets, self-ligating Damon SL II brackets and Time Plus brackets coupled with stainless steel, nickel-titanium and beta-titanium archwires. All brackets had a 0.022-inch slot, and five different sizes of orthodontic wire alloys used. Each bracket-archwire combination was tested 10 times, and each test was performed with a new bracket-wire sample. Time Plus self-ligating brackets generated significantly lower friction than both the Damon SL II self-ligating brackets and Victory brackets. However, the analysis of the various bracket-archwire combinations showed that Damon SL II brackets generated significantly lower friction than the other brackets when tested with round wires and significantly higher friction than Time Plus when tested with rectangular archwires. Beta-titanium archwires generated higher frictional resistances than the other archwires. All brackets showed higher frictional forces as the wire size increased. These findings suggest that the use of an in vitro testing model that includes 10 brackets can give additional interesting information about the frictional force of the various bracket-archwires combinations to the clinician and the research worker. 相似文献
10.
Tecco S Farronato G Salini V Di Meo S Filippi MR Festa F D'Attilio M 《Cranio : the journal of craniomandibular practice》2005,23(1):53-66
The authors compared postural changes produced in 20 Caucasian female children treated with the Frankel Functional Regulator appliance (FR-2) (Frankel Industries, Morangis Cedex, France) using cephalometric tracings and comparing the tracings to 20 untreated Class II controls from the University of Chieti. Each patient in the study group was treated for exactly two years by the same operator using the FR-2 appliance and a standardized design and clinical technique, including prefunctional orthodontics where indicated. The average starting age was 8.4 yrs. (SD+/-2.1). At the end of the therapy, the average age was 10.3 yrs. (SD+/-2.4). Two teleradiographs were made of each patient: the first one at the beginning of treatment and the second one after six months. The radiographs were taken with the subjects standing in the ortho-position with no ear rods in the cephalostat; mirror position was carried out. In order to detect errors due to landmark identification, duplicate measurements were made using ten radiographs, and the error variance was calculated using Dahlberg's formula. Thirty-seven variables were studied. The cervical lordosis angle (CVT/EVT) was significantly higher in the study group as compared to the control group (p<0.05) at the end of treatment, probably due to a significant backward inclination of the upper segment of the cervical column (OPTNer and CVTNer) in the treated group (p<0.001 and p<0.01) from pre- to posttreatment. There was no significant change in the lower segment of the cervical column inclination (EVT/Ver). The changes resulted in a weak association in the multiple regression model to an increasing of maxillary base length and mandibular protrusion (R2=0.272; p<0.05). Other variables in the multiple regression were not significant. 相似文献