Reversible changes of visual acuity and pattern-electroretinograms after blue-green argon laser photocoagulation of diabetic patients

Visual acuity, color vision, pattern-visual-evoked-potentials (P-VEPs) and pattern-electroretinograms (P-ERGs) were measured in 13 diabetic subjects before, and 24 hours and 5 weeks after blue-green argon laser treatment. As control, the same examinations were performed in 7 normal subjects and 7 diabetic patients before and after slit lamp examination with the Goldman three mirror contact lens.Visual acuity and P-ERG amplitudes were significantly reduced one day after the laser treatment, while 5 weeks after the laser coagulation, visual acuity and P-ERG amplitudes recovered to pretreatment values. The control group showed no significant changes after slit lamp examination. Since fluorescein angiography revealed no macular changes after laser treatment, the possibility of a reversible functional light damage after blue-green argon laser coagulation (ALC) is discussed.This study was supported by the Medizinisch - Wissenschaftlicher Fonds des Bürgermeisters der Bundeshauptstadt Wien.     

FT-IR光谱法研究TA9902抑制Aβ1-42聚集的分子机制

目的：研究TA9902引起Aβ1-42二级结构变化，了解其抑制Aβ聚集和纤维形成的机制。 方法： 用傅里叶变换红外光谱法（FT-IR）曲线拟合定量分析和特征频谱分析Aβ老化后及TA9902干预后二级结构的变化。 结果： 1 700-1 600 cm-1之间的酰胺I带分析，Aβ1-42单独孵育30 min时，β-折叠片为46.53％；Aβ1-42老化72 h，β-折叠片为65.13％，β-折叠片增加了19.4％。TA9902与Aβ1-42作用β-折叠片为29.04％；与Aβ1-42老化72 h相比，TA9902的存在明显减少β折叠片的含量(下降了36.09％)，β-转角的含量明显升高(升高57.56％)，α-螺旋也略有升高（2.93％）。呈现出明显的β折叠片向β-转角的转化。其它基团特征峰位显示，TA9902中有酮类尤其是饱和链状酮或α-二酮和烷烃类的-CH2和-CH参与了Aβ1-42的分子变构。 结论： TA9902明显抑制Aβ1-42β-折叠的形成，同时也使Aβ1-42肽的侧链基团发生了化学修饰，提示Aβ的聚集和纤维形成与其分子β-折叠的形成和侧链基团发生了化学修饰有关。     

心脏螺旋波演化与驱动的计算机实验

我们利用FitzHugh-Nagumo(FHN)类型方程,对二维心肌可激媒质系统螺旋波(Spiral wave,SW)的形成、演化和控制进行了数值模拟,主要有以下研究结果:(1)改变系统的可激性,不会影响SW的激发区宽度,却改变SW的自转周期和旋波核的大小;当可激性达到某一极限值时,SW的自转周期与旋波核的半径趋于无穷大,系统不再出现SW。(2)对SW的均匀近共振小电流驱动,可以引导旋波头(Spiral wave tip,SWT)的漂移运动;当驱动频率接近SW的自转频率时,SWT会沿着圆周漂移,当驱动频率达到共振频率时,SWT会沿着直线漂移。     

中医灸与人体穴位红外辐射光谱特性研究

本文通过锁相放大技术测到人体不到1cm^2面积的体表红外辐射光谱。通过对这些光谱的归一化处理后发现，不同人体和同一人体的不同穴位，尽管其红外辐射绝对光谱及强度相差很大，但归一化光谱都有相当的一致性与可比性。进一步将人体发射的平均归一化光谱与中医艾条灸、隔姜灸、隔蒜灸及隔附子饼灸点燃过程中的光谱比较发现，后面三种间隔灸与人体自发辐射的光谱有着惊人的一致性，而艾条灸等的光谱却相差甚远。     

Antimicrobial effect of radiation of ionized plasma

Department of Experimental Surgery, Interfaculty Laboratory Complex, and Department of Clinical Laboratory Diagnosis, Postgraduate Medical Faculty, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Kupriyanov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 110, No. 10, pp. 413–145, October, 1990.     

使用瞳孔孔径动态变化测量分析装置定量检测正常人瞳孔对光反射

目的：定量观察正常人瞳孔对光反射。方法：以瞳孔孔径动态变化测量分析装置连续摄录并且分析127名正常人瞳孔直径，分析不同年龄的瞳孔对光反射的变化；结果：不同年龄组的瞳孔对光反射的瞳孔收缩速率和收缩时间不同，年龄越大，瞳孔收缩速率越慢。年龄越小，瞳孔收缩时问越短。结论：瞳孔孔径动态变化测量分析装置能较好地定量检测人瞳孔对光反射。     

乳腺癌的影像普查技术进展

介绍了用于常规乳腺检测的X线摄影、超声成像和红外成像等各种影像学技术,通过分析这些技术的病理学以及影像学特征,找到它们在普查学中的意义。此外,还介绍了一种新兴的技术——热断层成像。     

Self‐Assembly of Dendritic Macromolecules Based on the Ionic Interaction of Linear Chain Polyelectrolyte Cores with Oppositely Charged Focal Ionogenic Groups of Dendrons

Summary: A new principle for the design of dendritic macromolecules – the ionic binding of linear chain polyelectrolyte with oppositely charged focal ionogenic groups of dendrons – has been developed. The majority of the dendritic ionic complexes (DICs) are prepared with poly(styrenesulfonic acid) (PSS) as a polymeric core and L ‐aspartic acid dendrons of different generations. Two series of DICs were prepared using PSS and aspartic dendrons bearing terminal (located at the external periphery) methoxycarbonyl and hexyloxycarbonyl groups (C1‐n and C6‐n respectively where n is the generation number). Ionic binding of about 100% was found for dendrons of Generation 1–3. The solubility of the DICs was examined and the DICs prepared were studied by IR spectroscopy, ¹H NMR and viscometry.

Dendritic ionic complexes prepared using poly(styrenesulfonic acid) acid and aspartic dendrons bearing terminal methoxycarbonyl and hexyloxycarbonyl groups.     

Sleep and daytime sleepiness in retinitis pigmentosa patients

OBJECTIVE: We examined sleep, daytime sleepiness and the ability to stay awake during the day in patients affected with retinitis pigmentosa (RP), to further delineate the role of photoreceptors in the circadian cycle. METHODS: Twelve individuals diagnosed with RP (40 +/- 8 years) And 12 normally sighted healthy individuals (39 +/- 7 years) matched for age, body mass index (BMI) and sex were selected for the study. Participants had their sleep recorded on two consecutive nights and were monitored on the two following days. On the first day, their ability to stay awake and on the second, their sleep propensity were assessed using the Maintenance of Wakefulness Test (MWT) and the Multiple Sleep Latency Test (MSLT), respectively. Self-report measures were obtained using the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Toronto Hospital Alertness Test (THAT). RESULTS: Subjective daytime sleepiness (ESS: 9 +/- 5 vs. 6 +/- 4, P=0.053) and objectively measured sleep propensity (MSLT: 10 +/- 5 vs. 17 +/- 3 min, P < 0.000) were significantly higher in RP patients than controls, whilst their alertness (THAT: 29 +/- 9 vs. 38 +/- 7, P=0.016) and ability to stay awake (MWT: 21 +/- 9 vs. 29 +/- 2 min, P=0.006) were significantly reduced. Retinitis pigmentosa participants had more disturbed nighttime sleep, with significantly more awakenings (arousal index: 14 +/- 8 vs. 8 +/- 6 h, P=0.039), and tended to have less rapid eye movement (REM) sleep (19 +/- 5 vs. 22 +/- 3%, P=0.094). CONCLUSION: Patients with RP have increased daytime sleepiness, reduced alertness and more disturbed nighttime sleep of poorer quality than their normally sighted counterparts, suggesting an influence of photoreceptor degeneration on the circadian cycle.     

He-Ne激光、微波、红外线和TDP灯照射对血粘度与红细胞影响的比较研究

目的比较研究He-Ne激光、微波、红外线和TDP灯照射对高血粘的影响,探索能否利用He-Ne激光、微波、红外线和TDP灯照射降低血液粘度,改善血循环.方法每份血样等分5份,1份作对照,对另外4份分别作He-Ne激光、微波、红外线和TDP灯照射处理.结果高血粘血样经He-Ne激光、微波、红外线和TDP灯照射作用后,全血表观粘度η降低(P＜0.01)、红细胞电泳率EPM加快(P＜0.01),血沉速度ESR提高(P＜0.01),一氧化氮、全血黏度、全血还原黏度降低(P＜0.01).红细胞变形指数降低(P＜0.01),红细胞聚集时间增加(P＜0.01),红细胞压积降低(P＜0.01),纤维蛋白降低(P＜0.01).结论He-Ne激光、微波、红外线和TDP灯照射能改善高血粘血样的流变特性.而且激光效果最好,依次是TDP灯、微波和红外线.进一步了解物理与临床治疗的密切关系.