自发性高血压大鼠的微血管改变及其与血管内皮细胞损伤的关系

目的：探讨自发性高血压大鼠（SHR）的微血管改变与血管内皮细胞（VEC）损伤的关系。方法：以10只成年Wistar－Kyoto大鼠（WKY）为正常对照组（WKY组）。观察、计数10只成年SHR的肠壁微动脉管径和分支数，同时测定血浆亚硝酸根（NO2－）和内皮素（ET）并与WKY组对照。结果：SHR组的肠壁各级微动脉管径较WKY组变细（P＜0．01～0．001）、各级微动脉总条数较WKY组减少（P＜0．001～0．0001）；SHR组的血浆NO2-水平和K值［10g（NO2－／ET）」较WKY组低（P＜0．05～0．001），而ET较WKY组高（P＜0．05）。血压和K值分别与肠壁微动脉管径和条数呈负相关和正相关（P＜0．005～0．001）。结论：高血压的微血管结构异常与VEC损伤有密切的关系。     

舌粘膜及粘膜下血管网的构筑及其临床意义

本研究应用手术显微镜和扫描电镜观察了人舌粘膜的微血管构筑。舌深动脉长支和舌背动脉终支在舌粘膜下形成一完整的致密动脉网,跨越界沟和舌正中线,成为一整体。由动脉网发出微动脉支进入舌粘膜内,形成粘膜内的毛细血管网和各种乳头毛细血管丛。另外,还讨论了舌粘膜下馓血管构筑和舌瓣设计与临床舌诊的关系。     

止消通脉宁对糖尿病微血管合并症患者心功能影响的临床研究

为了探讨中药复方止消通脉宁对有微血管合并症的亚临床期糖尿病心脏病患者心功能的影响 ,我们选择了 63例 2型有微血管合并症的糖尿病患者 ,分为对照组 (2 0例 )和治疗组 (4 3例 ) ,分别使用常规疗法和加用止消通脉宁的治疗方法 ,疗程 4周 ,着重观察心功能、眼底和 2 4h尿白蛋白定量的改变。结果 :止消通脉宁可以明显改善心功能、减少尿白蛋白定量 ,而常规治疗对照组则无明显作用。表明止消通脉宁干预治疗可以改善有微血管合并症的亚临床期糖尿病心脏病患者心功能的异常 ,从而预防和治疗糖尿病心脏病。     

基于络病理论从芳香通络疗法论治冠状动脉微循环障碍

近年来,随着冠脉介入诊疗技术的普及,冠状动脉微循环障碍（CMD）的检出率逐步升高,CMD已成为远期心血管事件的独立预测因子。络病理论认为CMD病位在络,病机为心络瘀阻、心络郁滞/虚滞和心络绌急,通络成为其基本的治法治则。芳香类药物可直接入络搜邪,芳香通络疗法较单纯活血通络法疗效更佳。故而从络病理论、芳香通络疗法的立法依据等方面,对芳香通络疗法治疗CMD进行论述。     

Endoscopic-assisted microvascular decompression for trigeminal neuralgia secondary to vertebrobasilar dolichoectasia: A case report

Introduction and importanceTrigeminal neuralgia (TN) secondary to vertebrobasilar dolichoectasia (VBD) was a rare condition. This paper reported a successful endoscopic-assisted microvascular decompression (MVD) for TN secondary to VBD.Case presentationA 53-year-old male with a history of myocardial infarction and heart failure complained of left refractory facial pain three years prior to admission. His pain was intermittent, electrical-like, severe, sharp, and radiated along the maxillary and mandibular branches. He used carbamazepine 600 mg daily. Brain magnetic resonance imaging revealed a neurovascular conflict between VBD and the left trigeminal nerve. The endoscopic-assisted MVD was indicated. The shredded neurosurgical sponges were interposed between VBD and trigeminal nerve. The 0° and 30° rigid rod-lens endoscope was used to explore and confirm the complete decompression. Postoperatively, TN was disappeared entirely. At a three-month postoperative, no facial pain and paraesthesia were found. The patient discontinued carbamazepine permanently.Clinical discussionMVD was still the most effective treatment. An inspection of root entry zone (REZ) and complete MVD with a solely operating microscope were challenging due to the massive diameter of VBD and multiple offending arteries behind the VBD. However, the wide viewing field and high-quality resolution of endoscopes allowed better visualization of REZ and neurovascular conflicts behind neural structures and least cerebellar retraction. This is essential in case of less potential space created by VBD.ConclusionEndoscope-assisted MVD allowed better visualization of REZ and neurovascular conflicts behind neural structures and least cerebellar retraction in management of trigeminal neuralgia secondary to VBD.     

抑制血管生成对颊粘膜鳞癌微血管构筑的影响

目的 了解抑制血管生成对颊癌微血系统空间配布的影响,进而了解对肿瘤局部生长、浸润及转移的作用。方法 应用鱼精蛋白进行实验治疗,结合扫描电镜肿瘤生血管系统的变化规律。结果 鱼精蛋白确有抑制智力;这生成的作用,主要表现为延缓肿瘤血管生成的发和因管空间结构的建立,促进血管成熟,因此而抑制肿瘤生长、浸润和转移。结论 通过抑制血和生成有可效地阻止肿瘤生长和转移所依赖的血和系统建立和发展,从而限制肿瘤细胞局部     

Ⅱ型糖尿病微血管并发症与高血压的关系

采用均衡对照的原则,将162例Ⅱ型糖尿病患者分为合并高血压组和未合并高血压组;比较两组间糖尿病肾病和糖尿病视网膜病变的发生率,并就Ⅱ型糖尿病微血管病变的相关因素进行多元回归分析。研究表明,Ⅱ型糖尿病合并高血压组微血管病变的发生率显著高于未合并高血压组(P<0.05);相关分析表明,糖尿病微血管病变与高血压病程呈正相关。提示高血压是糖尿病微血管病变的相关危险因素。     

Refluent testicular autotransplantation by Domini's method

Autotransplantation presently constitutes the best option for the surgical treatment of non-palpable retained intra-abdominal testes. Silber first proposed this technique in 1978; it is not suitable in children under 3 years of age because of the small caliber of the testicular artery. In 1986 Dòmini, mindful of the problem of arterial vascularisation, carried out refluent testicular autotransplantation (RTAT), where a natural anastomosis between the testicular and deferential arteries is used. Venous drainage is guaranteed by performing a microsurgical anastomosis between the internal spermatic and inferior epigastric veins.At our institution this technique has been employed since 1990, replacing staged orchidopexy. We report a 2-year experience (1990–1992) in seven children who underwent RTAT and discuss the results obtained and the technique used.     

Extravascular chest wall technetium 99m diethylene triamine penta-acetic acid: implications for the measurement of renal function during renography

Measurement of individual kidney glomerular filtration rate (IKGFR) from the gamma-camera technetium 99m diethylene triamine penta-acetic acid (^99mTc-DTPA) renogram requires a continuous measurement of arterial activity. This is usually based on a region of interest (ROI) placed over the cardiac blood pool on the posterior view, with the assumption of negligible contamination from activity in the extravascular space of the chest wall. By injecting a small dose of technetium 99m human serum albumin (HSA) before the^99mTc-DTPA in 12 patients undergoing routine renography, the contribution of extravascular activity to the total signal recorded over the cardiac blood pool was calculated to be 11.0% (SE 2.1%) 1.5 min after DTPA injection, rising to 35.1% (SE 2.5%) at 15 min. Subtraction of the time-activity curve recorded from a ROI of the same size over the right lung generated a pure blood signal as shown by almost identical HSA/DTPA signal ratios recorded in blood samples taken 5 min after HSA and 15 min after DTPA and from the gamma-camera at the corresponding times. The effect of using a cardiac blood pool time-activity curve uncorrected for extravascular activity was to overestimate IKGFR by an average factor of 1.17 (SE 0.03). Offprint requests to: A.M. Peters