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991.
992.
PHARMACOKINETICSOFCUPRIC-BIS(SALICYLALDEHYDE-2-FURANTHIOCARBOXY-HYDRAZONATE)DICHLORIDE(CSFTCH)INRABBITS¥GaoYunsheng;ZhuYuyun(... 相似文献
993.
Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington's disease and schizophrenia 总被引:3,自引:0,他引:3
The technique of quantitative autoradiography was used to examine the effects of Huntington's disease (HD) and schizophrenia on the organization of striatal dopamine (DA) D1 and D2 receptors. Whereas the striatum of HD cases showed a reduction in the density of D1 ([3H]SCH 23390) and D2 ([3H]spiroperidol) receptors, the patterning of D2 receptor loss did not match that of the D1 receptor loss. The HD loss of D1 D1 receptors (65%) is far greater than the loss of D2 receptors (28%). Whereas there was a dorsal-ventral gradient of effect on both receptor subtypes, the effects of HD on D2 receptors in the ventral putamen (PUT) and nucleus accumben septi (NAS) were minimal. Similarly, muscarinic M1 and M2 receptors demonstrate different patterns of alteration in HD. The M2 subtype, labeled with [3H]N-methylscopolamine (in the presence of excess pirenzepine to occlude M1 sites), was depleted far more than the M1 receptor subtype, labeled with [3H]pirenzepine. Although the effects of HD on [3H]mazindol labeling of DA terminals were more heterogeneous, there appeared to be a relative preservation of this afferent input to the striatum of the HD cases. In the schizophrenic cases, our autoradiographic studies confirm previous reports of an elevation of D2 receptor density in the striata of many schizophrenics. This increase was evident even though two of the three cases were known to have not been treated with neuroleptics, and the third case may also have been drug naive. However, the increase was far greater in the NAS (164%) and ventral PUT (173%) than more dorsally in the striatum (68%). The density of D1 receptors and DA terminals labeled with [3H]mazindol in the striatum of schizophrenics was not significantly different from that of control cases. Thus in both HD and schizophrenia, the ratio of D2/D1 receptors is altered in favor of the D2 population, particularly in the NAS. 相似文献
994.
目的研究S波段高功率微波(HPM)辐射后乳鼠心肌细胞的损伤效应及其机制。方法采用平均功率密度为5~30mW/cm^2的S波段HPM模拟源辐射原代培养的乳鼠心肌细胞,应用流式细胞术、原子力显微镜观察辐射后心肌细胞凋亡和坏死率、[Ca^2+]。及细胞膜形态。结果10—30mW/cm^2的S波段HPM辐射后6h,心肌细胞凋亡和坏死率增加(P〈0.05或P〈0.01),且随辐射剂量增大,坏死细胞增多;30mW/cm^2 HPM辐射后即刻[Ca^2+]i升高(P〈0.01),细胞膜发生穿孔。结论10—30mW/cm^2的S波段HPM辐射可造成心肌细胞凋亡和坏死,[Ca^2+];升高以及细胞膜穿孔,是S波段HPM辐射致心肌细胞损伤的重要机制。 相似文献
995.
BACKGROUND: It is established that the A3 domain in von Willebrand factor (VWF) contains the major collagen-binding site. However, there are conflicting reports describing the capacity of the A1 domain to interact with collagen types I and III. METHODS: In this study, we have used recombinant VWF-A1 polypeptides, as well as conformation-specific monoclonal antibodies (mAb), to analyze the A1-collagen interaction. RESULTS: The A1 domain bound to collagen with K(d) approximately 8.0 nm and this binding was blocked by the mAb 6G1, which blocks the interaction between ristocetin and VWF. In addition, collagen-bound A1 protein was able to support flow-dependent adhesion of platelets, demonstrating that the binding sites for collagen and glycoprotein (GP)Ib are different. Analysis with two conformation-specific mAb demonstrated that the structure of the A1 domain changed as a result of the binding to collagen. In contrast, the antibodies failed to detect conformational change in the G1324S mutant (type 2M von Willebrand disease). Thus, direct binding to collagen induces a change in the structural conformation within the VWF-A1 domain, and the G1324S substitution prevents this conformational change. CONCLUSION: This study has shown that the isolated A1 domain can simultaneously bind to collagen and platelet GPIb, supporting platelet adhesion under high-flow conditions. In addition, this study has used mAb to demonstrate that the binding of the isolated A1 domain or full-length VWF to collagen is accompanied by a conformational change in A1 domain. 相似文献
996.
《Journal of labelled compounds & radiopharmaceuticals》2006,49(8):707-732
Results are reported on the regioselective C‐deuteriation of 2‐methyl‐tetralone using a series of D‐sources and tertiary amines as potential mediators. The results presented further aid the understanding of kinetic deuteriation of both ‘base‐containing’ and ‘base‐free’ enolates. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
997.
Shuei-Tu Chen Ko-Hsiu Lu Hai-Lun Sun Wen-Tung Chang Ko-Huang Lue Ming-Chih Chou 《Pediatric allergy and immunology》2006,17(1):49-54
Leukotriene receptor antagonists (LTRAs) were recently added to the method of treating allergic rhinitis (AR). However, in children under 6 yr old, there has been no study about its efficacy in treating AR. We aim to compare the clinical efficacy of montelukast, cetirizine and placebo in the treatment of children from 2 to 6 yr old with perennial allergic rhinitis (PAR), to see if there are any significant differences. Sixty children were selected and treated with montelukast, or cetirizine, or placebo once daily. The efficacy of the three agents was compared with the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) and Total Symptom Score (TSS) by diary. In addition, we also examined serum IgE, serum eosinophil cationic protein (ECP), blood eosinophil counts, nasal airway resistance (NAR) and eosinophil percentage in nasal smears. The results revealed that both montelukast and cetirizine were significantly efficacious compared with placebo in NAR, eosinophil percentage in nasal smears, PRQLQ, TSS and all symptom items except nasal itching, throat itching and tearing. For nasal itching, only cetirizine was significantly efficacious. On the other hand, for night sleep quality, montelukast was significantly superior to cetirizine. 相似文献
998.
晚发性抑郁患者情绪调节机制的ERPs研究 总被引:4,自引:0,他引:4
目的采用事件相关电位探讨晚发性抑郁患者情绪调节障碍的神经生理机制。方法被试者包括16例晚发性抑郁患者(发病年龄≥60岁)与16名健康老年人。采用Go/Nogo实验范式,要求被试者对刺激序列中双个三角形进行按键反应(Go),单个三角形不反应(Nogo)。记录32导脑电。结果健康老年人中,Nogo刺激产生了明显的额中央区分布的N2Nogo和P3Nogo;与对照组相比,病例组的N2Nogo。波幅明显增高,而P3Nogo波幅显著降低,两者潜伏期无显著差异。结论晚发抑郁患者存在情绪调节障碍,其电生理学指标为N2Nogo明显增高和P3Nogo的显著降低,为晚发性抑郁的诊断和治疗提供了一定的客观评价指标。 相似文献
999.
The peptide Leu-Asp-Asp-Ser-Lys-Arg-Val-Ala-Lys-Arg-Lys-Leu-Ile-Glu, which corresponds to sequence 124 to 137 of c-erb-A protein, was synthesized and tested as substrate for protein kinase C (PKC). Although a typical recognition sequence for PKC, consisting of a cluster of basic residues, is found on the C-terminus side of serine, its phosphorylation was totally prevented by the presence of the two acidic residues on the amino-terminus side. Three analogs in which aspartyl residues were successively replaced with alanine were studied and the influence of the acidic side chain in modulating phosphorylation by PKC was thus possible to determine. The results show that the presence of a single aspartyl residue located in positions i-1 or i-2 with respect to the phosphorylable residue can almost totally abolish the positive effect of a highly favorable cluster of basic residues. These observations highlight the role of negative substrate specificity determinants in settling the protein substrate profile of protein kinase C. 相似文献
1000.