碘伏用于超声根管预备预防根管治疗期间痛的临床研究

目的观察碘伏用于超声根管预备对死髓牙根管治疗期间痛(endodontic interappointment pain EIP)发生率的影响及防治效果.方法对159例180颗慢性根尖周炎患者,随机分为3组(每组60颗患牙).第1组为传统手持器械对照组,第2组为超声生理盐水对照组,第3组为超声碘伏治疗组.采用临床观察分析法,观察治疗组与对照组临床反应的差异.结果超声治疗组Ⅱ～Ⅲ级EIP发生率为10%,对照组为36.67%(P＜0.01),有显著差异性.结论碘伏应用于超声根管预备能预防和降低EIP的发生并减轻其疼痛程度.     

Ziehl-Neelsen-维多利亚蓝-碘绿复合染色法显示抗酸杆菌

目的 :探讨显示皮肤活检组织中抗酸麻风杆菌、弹力纤维和细胞等组织成分的复合染色法。方法 :运用Ziehl Neelsen(Z N)苯酚复红染色液、维多利亚蓝 (Victoriablue ,VB)染色液、碘绿 (iodinegreen ,IG)和马汀氏黄 (Mar tiusyellow ,MY)染色液对皮肤活检组织进行复合染色。结果 :组织内结核样结节中麻风杆菌显示为红色 ,细胞核呈淡绿色 ,细胞浆无色 ,结节周围的弹性纤维呈蓝色 ,基质呈淡黄色。结论 :Z N原法染色单一 ,对比效果差 ,应用碘绿、马汀氏黄和维多利亚蓝复合的改造染色液 ,能更好显示组织中的麻风杆菌 ,以及包绕于结核样结节周围的弹力纤维等成分 ,该方法是一种对比清晰 ,可靠的复合染色法     

复合红外光治疗寻常型痤疮临床观察

目的 评价复合红外光治疗寻常型痤疮的疗效及其安全性.方法 将120例门诊痤疮患者随机分为两组,实验组60例采用复合红外光美容仪照射治疗1～8周,对照组采用暗疮面膜治疗1～8周,在治疗的第1、2、4、8周进行随访,严格记录每次治疗后皮损变化及不良反应,以治疗后炎性皮损减少百分率评价疗效,并观察其安全性.结果 实验组治疗的总有效率为91.67%,对照组治疗的总有效率为83.33%,经秩和检验,P＜0.05,两者治疗有显著性差异,实验组在治疗过程中除出现一过性红斑外,未发现其他不良反应.结论 复合红外光治疗寻常型痤疮疗效显著、起效快、疗程短、无痛苦、安全性高.     

复方天棘胶囊对老龄鼠血气影响的研究

本研究选用昆明种老龄鼠５０只，随机分为正常对照组、阳性对照组和复方天棘胶囊高、中、低剂量组；每组１０只。观察灌服复方天棘胶囊溶液对实验性老龄鼠血气的影响。结果表明，老龄鼠灌服２．０、１．０和０．５ｇ／ｋｇ体重复方天棘胶囊溶液及５．０ｇ／ｋｇ体重红参水煎液１０天后，复方天棘胶囊各剂量组均有不同程度的升高动脉血氧分压（ＰａＯ＿２）和血氧饱和度（ＳａＯ＿２）的作用；且随剂量的递增，ＰａＯ＿２和ＳａＯ＿２明显升高，其中高剂量组升高ＰａＯ＿２和ＳａＯ＿２的作用最为明显（Ｐ＜０．０１）；红本组ＳａＯ＿２也有明显升高（Ｐ＜０．０１）。提示复方天棘胶囊具有升高ＰａＯ＿２和ＳａＯ＿２的作用。     

抗肿瘤药复方三生注射液的研究

复方三生注射液是由生附片等六味中药组成的静注用灭菌水溶液。本文综合报道了该制剂的制备方法,质量分析,抗肺癌作用的药理及临床等研究的主要内容。结果表明,本品是治疗中晚期肺癌有效的中药复方注射剂。     

Characteristics of β-endorphin-induced histamine release from rat serosal mast cells Comparison with neurotensin,dynorphin and compound 48/80

Summary Rat peritoneal mast cells were exposed to the neurohormone and basic opioid peptide -endorphin. -Endorphin induced a dose-dependent release of histamine from the mast cells. A significant histamine release was found at 5 mol/l of -endorphin and maximal release (35% of total) at 20 mol/l. The histamine release process was very rapid and terminated within 30 s at 37°C, and in this sense is very similar to the histamine release induced by compound 48/80 or neurotensin. The histamine release was temperature-dependent showing an optimum release around 30°C, and it was independent of available extracellular calcium, but was inhibited in the presence of high extracellular calcium concentrations. Naloxone, only in very high concentrations (10 mmol/l), inhibited the release, and the very same concentration also inhibited the neurotensin — as well as the compound 48/80-induced histamine release. Cromoglycate and benzalkoniumchloride, a 48/80 antagonist, both produced a progressive dose-dependent inhibition of -endorphin-, neurotensin- as well as compound 48/80-induced histamine release. Taken together, the findings indicate that the opioid peptide -endorphin induces a selective, energy-dependent release of histamine from peritoneal rat mast cells. The pattern of release has much in common with that of compound 48/80 and other basic peptides, such as neurotensin and substance P. In addition this pattern of release is similar to that induced by dynorphin. Send offprint requests to Anita Sydbom at the above address     

3种不同创基准备程序性治疗方法在慢性难愈性创面中的效果观察

目的 探讨清创换药、负压引流、富血小板血浆治疗的创基准备程序性治疗在慢性难愈性创面中的效果。方法 回顾性分析2017年5月—2021年5月江南大学附属医院收治的83例创基准备程序性治疗的慢性难愈性创面患者的临床资料,根据治疗方法不同分为清创换药组25例、负压引流组35例、富血小板血浆组23例。比较3组患者创面愈合时间、创面完全愈合患者占比,临床疗效,治疗前后视觉模拟疼痛评分（VAS）差值、温哥华瘢痕评定量表（VSS）评分,治疗前后创面感染指标差值,创面细菌阳性率及复发情况。结果 富血小板血浆组创面愈合时间短于清创换药组和负压引流组（P <0.05）,富血小板血浆组与清创换药组和负压引流组创面完全愈合患者占比比较,差异无统计学意义（P>0.05）;富血小板血浆组与清创换药组和负压引流组总有效率比较,差异无统计学意义（P>0.05）;富血小板血浆组治疗前后VAS评分差值高于清创换药组和负压引流组（P <0.05）,富血小板血浆组VSS评分低于清创换药组和负压引流组（P <0.05）;富血小板血浆组治疗前后C反应蛋白差值、白细胞计数差值均高于清创换药组和负压引流...     

Correlation-based decomposition of surface electromyograms at low contraction forces

The paper studies a surface electromyogram (SEMG) decomposition technique suitable for identification of complete motor unit (MU) firing patterns and their motor unit action potentials (MUAPs) during low-level isometric voluntary muscle contractions. The algorithm was based on a correlation matrix of measurements, assumed unsynchronised (uncorrelated) MU firings, exhibited a very low computational complexity and resolved the superimposition of MUAPs. A separation index was defined that identified the time instants of an MU's activation and was eventually used for reconstruction of a complete MU innervation pulse train. In contrast with other decomposition techniques, the proposed approach worked well also when the number of active MUs was slightly underestimated, if the MU firing patterns partly overlapped and if the measurements were noisy. The results on synthetic SEMG show 100% accuracy in the detection of innervation pulses down to a signal-to-noise ratio (SNR) of 10 dB, and 93±4.6% (mean± standard deviation) accuracy with 0 dB additive noise. In the case of real SEMG, recorded with an array of 61 electrodes from biceps brachii of five subjects at 10% maximum voluntary contraction, seven active MUs with a mean firing rate of 14.1 Hz were identified on average.     

负压封闭吸引对糖尿病溃疡愈合的促进作用

目的 在"创而床准备(WBP)"理论指导下,观察负压封闭吸引局部处理糖尿病溃疡的疗效.方法 收集2000年1月至2005年1月间收治的27例糖尿病溃疡患者作对照组,2005年1月至2007年6月的8例糖尿病溃疡患者为试验组.两组患者均经常规系统的治疗,试验组在创面的黑、黄期采用清创后负压吸引治疗.观察两组创而各分期间的演进情况.比较两组手术Ⅰ期修复率、入院首次及实施负压治疗后1、2、3周创面细菌学检查结果 .观察各期创面组织标本的HE染色和黄、红两期Ⅰ、Ⅲ型胶原纤维苦味酸-天狼猩红染色结果 及对其含量进行图像分析.结果 试验组患者创面各分期的演进速度、于术Ⅰ期修复率均优于以照组(100%比46%,P<0.05).治疗2周后试验组创面末检出致病菌,对照组检出率为66.7%(P<0.05).HE染色显示试验组各期间的演进类似于急性创面愈合过程,且试验组黄期Ⅰ、m型胶原总含量为12.28%,对照组为24.77%(P<0.01).结论 基于WBP方案的负压吸引治疗能促进糖尿病溃疡的创面愈合过程.