Context: Acne vulgaris is a puberty-onset chronic inflammatory disease of the pilosebaceous unit. Isotretinoin is a derivative of vitamin A commonly used for severe and nodulocystic acne. While isotretinoin has many side effects related to the eye, visual system and lacrimation, there is no information regarding isotretinoin’s influence on contrast sensitivity.Aim: To investigate the effect of isotretinoin on visual contrast sensitivity and the amount of lacrimation.Materials and methods: The study included 25 patients (16 females and 9 males) who underwent isotretinoin treatment. The treatment duration ranged from 4 to 7 months. Patients were examined both before the start and at the end of treatment using the Schirmer test in each eye. The contrast sensitivity measurement was performed both individually for each eye and in a binocular fashion using the Pelli–Robson Sensitivity Chart.Results: The results of the Schirmer test before treatment were 19.74?±?3.63?mm for the right eye and 19.66?±?3.63?mm for the left eye. Post-treatment measurement results were 17.24?±?3.5?mm for the right eye and 16.68?±?3.73?mm for the left eye. There was a statistically significant difference between the before and after treatment measurements (p?<?0.000). Before treatment, contrast sensitivity was 1.45?±?0.19 for the right eye and 1.42?±?0.2 for the left eye. The binocular measurement was 1.54?±?0.14. After treatment, the right eye was 1.47?±?0.19, the left eye was 1.46?±?0.18, and the binocular measurement was 1.54?±?0.18. There were no statistically significant differences between before and after treatment (p?>?0.05).Discussion: There are contradicting reports on the results of the Schirmer test. The only similar study that has evaluated contrast sensitivity used the drug acitretin, the results of which are consistent with those the present study.Conclusion: Our study is significant in that it is the first to investigate the effects of isotretinoin on visual contrast sensitivity that is closely associated with real-world performance. Our results need to be supported by future studies. 相似文献
Introduction: The incidence of adult acne is increasing worldwide. Despite clinical overlap with conventional acne, it has distinct features.
Areas covered: A literature search of English-language review articles, randomized control studies and retrospective studies conducted over the past 30 years was performed using PubMed and Google Scholar. Search terms included acne, adult, topical medication, oral medication and skin of color. We highlight important clinical features and treatment modalities pertinent to the evaluation and management of adult acne. Given the relative dearth of literature detailing treatment options specific to adult acne, we offer expert opinion regarding management of the condition especially in special populations such as skin of color and pregnancy.
Expert Opinion: It is unclear whether adult acne represents a distinct entity or a continuum of adolescent disease. Providers may opt to use topical medication as first-line, but should have a low threshold for switching to systemic therapy given the magnitude of psychosocial and emotional burden associated with the condition. 相似文献
It has not yet been established whether men in heterosexual relationships adapt their hormone levels to their female partner's menstrual cycle to allocate reproductive resources to the period when the female is actually fertile.
Aim
This prospective observational study tested the hypothesis that some males have peaks in testosterone or acne (a possible biomarker for androgen activity) near their partners' ovulation, whereas other males display the opposite pattern.
Methods
48 couples supplied menstrual cycle data, male salivary samples, and a protocol of daily activities for 120 days. Daily saliva samples were analyzed for testosterone concentrations by enzyme-linked immunosorbent assay. The main hypothesis was tested by analyzing whether each individual male's testosterone/acne response to ovulation (either an increase or a decrease in comparison to the individual's average levels) was stable over time. To do this, we analyzed the Spearman correlation between individually normalized periovulatory testosterone and acne during the first half of the study versus the second half of the study.
Outcomes
Correlation between each male individual's periovulatory testosterone and acne patterns during the first half of the study versus the second half of the study.
Results
No predictability in the male individuals' testosterone (Spearman's rho = ?0.018, P = .905) or acne (Spearman's rho = ?0.036, P = .862) levels during ovulation was found.
Clinical translation
The study being “negative,” there is no obvious translational potential in the results.
Strengths and limitations
The main strength of this study lies in the excellent compliance of the study participants and the large number of sampling timepoints over several menstrual cycles, thereby allowing each male individual to be his own control subject. A limitation is that samples were only obtained in the morning; however, including later timepoints would have introduced a number of confounders and would also have hampered the study's feasibility.
Conclusions
The current results strongly indicate that male morning testosterone levels neither increase nor decrease in response to the partner's ovulation. This discordance to previous laboratory studies could indicate either that (i) the phenomenon of hormonal adaptation of men to women does not exist and earlier experimental studies should be questioned, (ii) that the phenomenon is short-lived/acute and wanes if the exposure is sustained, or (iii) that the male testosterone response may be directed toward other women than the partner.Ström JO, Ingberg E, Slezak JK, et al. Male Testosterone Does Not Adapt to the Partner's Menstrual Cycle. J Sex Med 2018;15:1103–1110.相似文献
Dermatological diseases, among which acne vulgaris, have psychological impact on
the affected generating feelings of guilt, shame and social isolation.
Objectives
To compare quality of life, self-esteem and other psychosocial variables amongst
adolescents with and without acne vulgaris, and between levels of severity.
Methods
Cross-sectional observational study in a sample of 355 high school students from
the city of João Pessoa. Data collection was performed with questionnaires and
clinical-dermatological evaluation. The primary variables were the incidence of
AV; quality of life, set by the Children''s Dermatology Quality of Life Index and
Dermatology Quality of Life Index; and self-esteem, measured by the Rosenberg
Self-Esteem Scale. For calculation of statistical tests, we used the SPSS 20.0
software, considering p=0.05.
Results
The sample, with an average age of 16, showed 89.3% prevalence of acne vulgaris.
The most prevalent psychosocial issue was "afraid that acne will never cease",
present in 58% of affected youth. The median score of Quality of Life in
Children''s Dermatology Index was different amongst students with and without acne
vulgaris (p=0.003), as well as the Quality of Life in Dermatology (p=0.038)
scores, so that students with acne vulgaris have worse QoL. There was a
correlation between the severity of acne vulgaris and worse quality of life.
Self-esteem was not significantly associated with the occurrence or severity of
acne vulgaris.
Conclusions
acne vulgaris assumes significance in view of its high prevalence and the effect
on quality of life of adolescents, more severe at the more pronounced stages of
disease (p<0.001). The psychosocial impact of acne vulgaris should be valued in
the management of patients with this condition. 相似文献