捕“捉”漏网之鱼——隐蔽的胃癌

生活实例 许先生今年37岁，近2年来经常出现上腹部隐痛不适．常有嗳气，有时出现进餐后呕吐。在某大医院，许先生做了2次胃镜检查．均诊断为慢性胃炎。吃了不少治胃病的药．可疗效甚微。最近．他去另一家医院做腹部CT检查，报告为胃癌。     

“大健康”金象的个性

一贯以营销创新形象示人的金象大药房，在北京药店行业内富有活力。今年开始，金象大药房将此营销“活力”往供应链的前端位移：短短3个月内，金象大药房分别与马应龙药业集团、日本森下仁丹株式会社达成战略合作，拿下了八宝眼霜、提香蜜丸等健康美容产品的地区或全国代理权；近期还将引进澳大利亚知名品牌“斯俪魅”，推行“替餐”即健康体重管理概念。     

1例重型颅脑损伤术后继发蛛网膜下腔出血腰大池置管引流的护理

目的 探讨重型颅脑损伤术后继发蛛网膜下腔出血腰大池置管引流的护理方法 .方法 术前心理护理,术后病情观察、引流管护理、预防并发症护理,结合出院指导.结果 在精心护理下患者疗效显著,无严重并发症发生.结论 做好蛛网膜下腔出血腰大池置管持续引流的护理配合,可保证疗效、减少并发症.     

功能性消化不良中医证候及症状分布特点的研究

目的 探讨功能性消化不良的中医证候及其分类证候症状分布规律.方法 采用流行病学方法 ,对565例功能性消化不良患者进行调查分析,将调查所得数据建立数据库,采用统计学方法 分析.结果 功能性消化不良中医证候以脾虚气滞证、脾胃湿热证、脾胃虚弱(寒)证、寒热错杂证为主要证候;症状与肝脾关系最为密切,且不同的证候症状出现频次各不相同.结论 功能性消化不良的主要证候为脾虚气滞证、脾胃湿热证、脾胃虚弱(寒)证、寒热错杂证;分类证候症状出现频次各有不同模式特点,其症状与肝脾关系最为密切.     

谱效结合方法对绵茵陈大孔吸附树脂精制工艺的评价

目的 分别以HPLC指纹图谱的主成分保留率和急性肝损伤的药效模型为指标,评价绵茵陈提取液的大孔吸附树脂精制工艺的合理性.方法 以HPLC指纹图谱的主峰保留率为指标,对绵茵陈提取液的精制工艺进行评价;建立CCl4致小鼠急性肝损伤模型,测定血清中谷丙转氨酶(ALT)、谷草转氨酶(AST),并观察肝组织病理学变化;进行小鼠灌胃给药的急性毒性实验,考察绵茵陈提取液精制前后口服给药的安全性.结果 绵茵陈提取液精制前后的HPLC指纹图谱基本一致;绵茵陈提取液精制前后的保肝作用无显著差异;绵茵陈提取液精制前后均未发现明显的急性毒性反应.结论 以HPLC指纹图谱和药效学实验相结合的评价方法 ,证实了绵茵陈提取液大孔吸附树脂精制工艺的合理性.     

肖传实：大医院联动小社区

在大型公立医院支援社区卫生机构的路径中，肖传实找准了大型公立医院的定位。与其他三甲医院热衷于扩充规模所不同的是，肖传实作为山西省医疗卫生事业的发源地—山西医科大学第二附属医院的院长，却始终在与社区较劲儿。在肖传实看来，我国的社区卫生就是“转型期的畸形儿”，因此无论是刚从海外学或归来，     

精神病患者感染肺结核的预防与护理

在精神科临床护理中，由于精神病患者疾病时间较长，长期慢性消耗导致患者抵抗力降低，易感性增高，常易发生传染病。据2000年结核病流行病学调查，我国现有结核菌感染者4亿人，结核病患者500万人，其中传染性肺结核病患者200万人，每年因患结核病死亡的人数达15万人。     

成人水痘26例临床分析

水痘是水痘．带状疱疹病毒引起的急性呼吸道传染病，多见于儿童，然而近几年来成人患者有逐渐增多的趋势，为了提高对大学生水痘的认识，预防水痘在校园的流行，现将我院2005年3月至2008年12月31日共收治成人水痘26例总结分析如下。1资料与方法1．1一般资料26例患者中，男17例，女9例，年龄19—24岁，平均21．5岁，发热1—3d出疹，平均1．5d，发热持续时间1—10d，平均6．3d，26例均未接种过水痘疫苗，住院5—20d，平均9d。     

弥漫性大B细胞淋巴瘤中CD40L的表达及意义

目的探讨弥漫性大B细胞淋巴瘤（DLBCL）组织中CD40L表达与DLBCL预后间的关系及意义。方法免疫组织化学法检测27例弥漫性大B细胞淋巴瘤、20例淋巴结反应性增生组织中CD40L的表达。结果（1）DLBCL中CD40L过度阳性率（25．93％）显著低于淋巴结反应性增生（63．64％），P〈0．05。（2）CD40L在Ⅲ、Ⅳ期DLBCL过度阳性率（14．29％）低于Ⅰ、Ⅱ期（38．46％），P〈0．05。CD40L过度阳性率在有结外浸润DLBCL（11．76％）低于无有结外浸润DLBCL（40％），P〈0．05。（3）DLBCL患者CD40L的过度阳性率与远处转移、临床分期均显著相关，P〈0．05。结论（1）CD40L过度阳性率与结外器官浸润及临床分期密切相关，其可能作为判断DLBCL侵袭性及预后的指标。（2）DLBCL中CD40L表达的减少可能是影响其发病的因素之一。     

Wnt pathway in the formation of ischemic brain injury*★ Interventional pathway of basic fibroblast growth factor

BACKGROUND: Basic fibroblast growth factor (bFGF) can reduce neuronal apoptosis following ischemia/reperfusion (I/R) injury. Mechanism of the phenomenon should be elucidated. OBJECTIVE: The goal of this study was to observe the effect of bFGF on the expressions of Dickkopf-1(DKK-1) and β-catenin in the Wnt pathway in hippocampal tissue of rats following brain I/R injury, in order to investigate the role of Wnt pathway in the formation of ischemic brain injury. DESIGN: Randomized controlled experiment. SETTING: Shenyang Medical College. MATERIALS: Thirty healthy 3 months old male Wistar rats, weighing 300–350 g, were provided by the Experimental Animal Center of Shenyang Medical College. Thirty rats were randomized into sham-operation group, model group and treatment group. Goat anti-rat monoclonal antibody β-catenin was purchased from SANTA CRUZ Company. BFGF was developed by Beijing SL Pharmaceutical Co., Ltd. METHODS: This experiment was carried out in the Shenyang Medical College between November 2005 and May 2006. ①Focal brain I/R by suture-occluded method was modeled in rats in the treatment group and model group. Their middle cerebral artery was occluded 1 hour and reperfused for 24 hours. While in the sham-operation group, only the right common carotid artery and external carotid artery of rats were occluded for 90 minutes. ② The rats in the treatment group were intraperitoneally injected with 10 μg/kg bFGF, and those in the other groups were intraperitoneally injected with the same amount of saline. MAIN OUTCOME MEASURES: Following I/R 48 hours, the expressions of β-catenin and Dickkopf-1 mRNA in the neurons of hippocampal CA1 region by immunohistochemical SABC and RT-PCR. RESULTS: Following I/R 48 hours, the expressions of β-catenin and Dickkopf-1 mRNA in the neurons of hippocampal CA1 region was evaluated by means of immunohistochemical SABC and RT-PCR. ① Expression of DKK-1 mRNA in the sham-operation group was at low level, it was significantly higher in the model group compared to the sham-operation group; Expression of DKK-1 mRNA in the treatment group was significantly lower than that in the model group. ② Expression of β-catenin in the cerebral cortex and hippocampal cytoplasm of rats: The mean gray scale of β-catenin of model group was significantly lower than that of sham-operation group (74.27±2.65 vs. 111.36±5.39，P < 0.05); The mean gray scale of β-catenin of treatment group was significantly higher than that of model group (86.18±7.41 vs. 74.27±2.65, P < 0.05). CONCLUSION: bFGF may influence Wnt pathway by participating in the regulation of DKK-1 mRNA and β-catenin expressions, and thereby protect neurons.