Linear lesions for treating the recurrence of persistent atrial tachyarrhythmia after cryoballoon ablation of atrial fibrillation

Overall, 133 patients underwent 170 procedures for the treatment of persistent ATa following an index cryoballoon pulmonary vein isolation (n = 715). After all the procedures, > 90% of the patients had a roof line, a mitral isthmus and/or septal line, and a cavotricuspid isthmus line. Ninety-two patients (69.2%) were in sinus rhythm after a median of 36 months since the index cryoballoon PVI. ATa: atrial tachyarrhythmia; cryo: cryoballoon; CTI: cavotricuspid isthmus; LSPV: left superior pulmonary vein; LIPV: left inferior pulmonary vein; PVI: pulmonary vein isolation; RF: radiofrequency; RSPV: right superior pulmonary vein; RIPV: right inferior pulmonary vein.

     

Age at menopause,body mass index,and risk of type 2 diabetes mellitus in postmenopausal Chinese women: The Henan Rural Cohort study

Background and aimThe present study was conducted to explore the stratified and joint effects of age at menopause and body mass index (BMI) with the risk of type 2 diabetes mellitus (T2DM) in Chinese rural adults.Methods and resultsA total of 15,406 postmenopausal Chinese women were included in this study. Multivariable logistic regression analysis was used to quantify the stratified and joint effects of age at menopause and BMI on T2DM. Overall, the mean age at menopause and BMI was 48.8 ± 4.7 years and 25.1 ± 3.6 kg/m², respectively. In general, data suggest that: 1) women with BMI ≥ 24 had a higher risk of T2DM, irrespective of age at menopause; 2) in women with BMI < 24, later menopause had a higher risk of T2DM (OR, 1.52; 95% CI, 1.16–2.01); 3) the risk of T2DM was higher only in patients with early or normal age at menopause and BMI ≥ 24, with 0R (95% CI) of (1.58, 1.28–1.94) and (1.48, 1.31–1.67), respectively.ConclusionOur findings suggest that: 1) women with BMI ≥ 24 had a higher risk of T2DM, irrespective of age at menopause; 2) in women with BMI < 24, a higher risk of T2DM was found only in those with later menopause; 3) women with later menopause had a higher risk of T2DM, irrespective of BMI; 4) in patients with early or normal age at menopause, a higher risk of T2DM was found only in patients with BMI ≥ 24.The Chinese Clinical Trial RegistrationChiCTR–OOC–1500669(URL:http://www.chictr.org.cn/showproj.aspx?proj=11375)     

肿瘤突变负荷位点检测准确性评价

目的使用肿瘤突变负荷国家参考品中高置信SNP/Indel位点标准集的参考品,评价肿瘤突变负荷检测试剂盒的位点检测准确性。方法采用TMB检测试剂盒(可逆末端终止测序法)检测肿瘤突变负荷检测国家参考品中高置信SNP/Indel位点标准集的参考品。首先将DNA片段化处理,进行末端修复、接头连接和文库扩增等步骤后构建文库;然后将文库杂交捕获;最后使用NextSeq 550 Dx基因测序仪进行测序。结果TMB-14-2%、TMB-14-5%和TMB-14-10%参考品的突变检测准确性分别为89.00%、95.20%、95.80%。结论高置信SNP/Indel位点标准集的参考品,能够用于评价肿瘤突变负荷检测试剂盒的位点检测准确性。     

Modic Ⅱ型改变对经皮椎间孔镜术疗效的影响

目的 探讨Modic改变对经皮椎间孔镜术疗效的影响。方法 回顾性分析2018年1月－2019年12月在该科行经皮椎间孔镜下腰椎髓核切除术（PELD）的43例腰椎间盘突出症（LDH）患者,根据磁共振成像（MRI）示是否伴有Modic改变将其分为MC组与对照组,分析两组患者术中出血量、手术时间、术前、术后3 d、术后3和6个月的腰痛及腿痛视觉模拟评分（VAS）、日本骨科协会评分（JOA）及Oswestry功能障碍指数（ODI）。结果 两组患者术中出血量、手术时间、术前腰痛VAS评分、术前及术后腿痛VAS评分、术前ODI与JOA评分比较,差异均无统计学意义（P > 0.05）,但术后3 d、术后3和6个月腰痛VAS评分MC组高于对照组（P < 0.01）,术后3和6个月MC组JOA评分均低于对照组（P < 0.01）,术后3和6个月MC组ODI均高于对照组（P < 0.01）,同时与术前相比,两组患者6个月时腰痛VAS评分、腿痛VAS评分、JOA评分及ODI均有改善（P < 0.05）。结论 经皮椎间孔镜术对伴随Modic改变（Ⅱ型）的LDH患者具有良好的疗效,是一种可靠、安全的治疗手段,但Modic改变会影响术后腰痛的缓解,针对此类患者需综合考虑治疗方案。     

招收飞行学员远视力标准降至0.8后屈光状态分析

目的探讨招收飞行学员远视力标准降至08后,视力合格学生的屈光状态。方法2012年3月—2013年3月参检学生290名,按照每只眼的远视力分组,视力0.8~0.9分为A组、1.0~2.0分为B组,2组学生散瞳后接受检影验光,观察其屈光状态。结果A组90.47%的参检学生眼屈光度在体检标准合格范围内,B组90.77%的参检学生眼屈光度在体检标准合格范围内,2组比较差异无统计学意义（P>0.05)。结论招收飞行学员远视力标准降至0.8后,眼屈光度在体检标准合格范围内,合格人数大幅增加,满足了招飞需求。     

Alcohol content variation of bar and restaurant drinks in Northern California

Objective:  To estimate the average of and sources of variation in the alcohol content of drinks served on premise in 10 Northern Californian counties.
Methods:  Focus groups of bartenders were conducted to evaluate potential sources of drink alcohol content variation. In the main study, 80 establishments were visited by a team of research personnel who purchased and measured the volume of particular beer, wine, and spirit drinks. Brand or analysis of a sample of the drink was used to determine the alcohol concentration by volume.
Results:  The average wine drink was found to contain 43% more alcohol than a standard drink, with no difference between red and white wine. The average draught beer was 22% greater than the standard. Spirit drinks differed by type with the average shot being equal to one standard drink while mixed drinks were 42% greater. Variation in alcohol content was particularly wide for wine and mixed spirit drinks. No significant differences in mean drink alcohol content were observed by county for beer or spirits but one county was lower than two others for wine.
Conclusions:  On premise drinks typically contained more alcohol than the standard drink with the exception of shots and bottled beers. Wine and mixed spirit drinks were the largest with nearly 1.5 times the alcohol of a standard drink on average. Consumers should be made aware of these substantial differences and key sources of variation in drink alcohol content, and research studies should utilize this information in the interpretation of reported numbers of drinks.     

Effects of dairy products consumption on inflammatory biomarkers among adults: A systematic review and meta-analysis of randomized controlled trials

AimsThis study aimed to summarize earlier studies on the effects of dairy consumption on inflammatory biomarkers in adults and to quantify these effects through meta-analysis.Data synthesisA comprehensive search of all relevant articles, published up to December 2019 indexed in PubMed, ISI (Institute for Scientific Information), EmBase, Scopus, and Google Scholar was done using relevant keywords. Randomized controlled trials (RCTs) that examined the effect of dairy products consumption, compared with low or no dairy intake, on inflammatory biomarkers in adults were included. Overall, 11 RCTs with 663 participants were included in this meta-analysis. We found that high consumption of dairy products, compared with low or no dairy intake, might significantly reduce CRP [weighed mean difference (WMD): −0.24 mg/L; 95% CI, −0.35, −0.14], TNF-α (WMD:- 0.66 pg/mL; 95% CI, −1.23, −0.09), IL-6 (WMD: −0.74 pg/mL; 95% CI, −1.36, −0.12), and MCP concentrations (WMD: −25.58 pg/mL; 95% CI, −50.31, −0.86). However, when the analyses were confined to cross-over trials, no such beneficial effects of dairy intake on inflammation were observed. In addition, high dairy intake might result in increased adiponectin levels (WMD: 2.42 μg/mL; 95% CI, 0.17, 4.66). No significant effect of dairy consumption on serum leptin (WMD: −0.32 ng/mL; 95% CI, −3.30, 2.65), ICAM-1 (WMD: −3.38 ng/ml; 95% CI, −15.57, 8.96) and VCAM-1 (WMD: 3.1 ng/mL; 95% CI, −21.38, 27.58) levels was observed.ConclusionsIn summary, the current meta-analysis indicated that dairy intake might improve several inflammatory biomarkers in adults. In most subgroups without heterogeneity, effects tended to be null. Study design and participants’ age were the main sources of heterogeneity. More research, with a particular focus on fat content of dairy foods, is recommended.