新化合物 A-失碳-17β-羟基-17α-乙炔基-Δ3(5),9(10)-雌甾二烯-2-酮的合成

报道新化合物A-失碳-17β-羟基-17α-乙炔基-Δ^3(5),9(10)-雌甾二烯-2-酮2的合成。文中探讨了用炔钾粗品对A-失碳-Δ^3(5),9(10)-雌甾二烯-2，17-二酮１和Ａ-失碳-６β，１９-环氧-Δ³-雄甾-2，17-二酮3的选择性炔化，分别得标题化合物2（44%）及Ａ-失碳-17β-羟基-17α-乙炔基-６β，１９-环氧-Δ³雄甾-2-酮４（６５％），４经还原性破开环氧、去羟甲基和去醋酰氧基合成了标题化合物２。四步总收率为３４％。     

人睫状神经营养因子结构和功能的研究

制备高活性的重组人睫状神经营养因子，并研究其生物学功能。方法：应用大肠杆菌表达ｈＣＮＴＦ，用片段插入和法研究其结构与功能关系；切断大鼠骨神经，局部及皮下给予ＣＮＴＦ，应用辣根过氧化物酶逆行追踪技术显示再生轴突通过修复部位的胞体。结果；ｈＣＮＴＦ分子中α－螺旋结构的维持对其生物活性十分重要Ｃ端松散地其生物活性贡献不大，Ｄ螺旋中后段可能与生物活性有密切关系；     

Clinical Studies on Functional Dyspepsia Treated with Different Dosage-Form of Zhishi Xiaopi Pill Recipe (枳实消痞丸方)

Ｄｙｓｐｅｐｓｉａｒｅｆｅｒｓｔｏｐａｉｎｏｒｄｉｓｃｏｍｆｏｒｔｆｏ ｃｕｓｅｄｉｎｔｈｅｅｐｉｇａｓｔｒｉｕｍ，ｗｈｉｃｈｗａｓｒｅｐｏｒｔｅｄｔｏｏｃｃｕｒｉｎｍｏｒｅｔｈａｎ 1 0 %ｏｆｏｕｔｐａｔｉｅｎｔｓｉｎｉｎｔｅｒｎａｌｍｅｄｉｃｉｎｅ，ａｎｄｎｅａｒｌｙｈａｌｆｔｈｅｐａｔｉｅｎｔｓｉｎｔｈｅｇａｓ ｔｒｏｉｎｔｅｓｔｉｎａｌ（ＧＩ）ｄｅｐａｒｔｍｅｎｔ（1）．Ａｌｍｏｓｔｈａｌｆｏｆｔｈｅｓｅｐａｔｉｅｎｔｓｗｉｔｈｄｙｓｐｅｐｓｉａｗｈｏｈａｖｅｎｏｄｅｆｉ ｎｉｔｅｏｒｇａｎｉ…     

应用射频技术阻断神经纤维的研究

目的　探讨应用射频技术行选择性脊神经后根切断术和验证其阻断神经纤维的可行性。方法　将 4 5只大鼠随机分成 3组 ,以实验确定的射频技术、苯酚注射、切断 3种方法阻断其坐骨神经 ,对阻断前和阻断后不同时间内坐骨神经功能进行评价 ,评价方法采用坐骨神经功能指数和神经组织形态学的轴突通过率。结果　射频组、切断组 2组大鼠的坐骨神经功能指数、轴突通过率差异均无显著性 (P >0 .0 5 ) ,而苯酚注射组的上述指标与前述 2组差异均有显著性 (P <0 .0 5 )。结论　直视下应用射频阻断神经 ,可以取得与切断神经相同的效果     

Sensory axonopathy in hereditary distal spinal muscular atrophy

A girl of 14 year is presented with a distal spinal muscular atrophy (SMA) with autosomal recessive inheritance. The technical findings are in agreement with the diagnosis. Light microscopical examination of sural nerve biopsy, including teased fiber studies and morphometry, showed no abnormalities. Electron microscopical investigation however demonstrated axonal pathology. The question arises if distal SMA is a distal axonopathy mainly of motor nerves, but to some extent also of sensory nerves.     

100例高血压病患者短程心率变异性分析

目的:评价自主神经活动在高血压病中的调节作用。方法:观测100例高血压病(Ⅰ组)和54例正常人(Ⅱ组)及高血压病伴心电图改变(ⅠA组)和不伴心电图改变(ⅠB组)心率变异性(以下称HRV)时域参数SDNN、rMSSD、PNN50、Bottom4项指标。结果:Ⅰ组与Ⅱ组差异有显著性(P<0.05);ⅠA组与ⅠB组组差异无显著性(P>0.05)。结论:在高血压病中,交感神经张力增高,副交感神经活动减弱及损伤可能是HRV降低的重要因素。     

甲状腺切除术中喉返神经损伤的预防

目的：探讨降低喉返神经损伤的方法。方法：2005年9月-2007年1月共有375例甲状腺手术患者，对其喉返神经损伤进行分析。结果：375例病人中有5例喉返神经损伤，其中甲状腺腺瘤3例，桥本甲状腺炎1例，甲状腺癌1例，损伤后立即行喉镜检查示声带处于外展位。给予营养神经治疗，15 d-3个月后完全恢复，喉镜检查示声带正常。结论：喉返神经损伤可以预防，关键是术者应熟悉喉返神经的解剖结构和变异，熟悉其与周围组织及血管的关系，要有手术区域的组织结构特别是喉返神经走行的“立体影像”。     

Organization of the trigeminal and facial motor nuclei in the hagfish, Eptatretus burgeri: a retrograde HRP study

We studied the trigeminal and facial motor nuclei of the hagfish by the retrograde HRP method. We distinguished 4 components in a single column of the motor nuclei of the trigeminal nerve and the facial nerve, viz., the pars magnocellularis of the trigeminal motor nucleus (mVm), the anterior part of the pars parvocellularis of the trigeminal motor nucleus (mVp1), the posterior part of the pars parvocellularis of the trigeminal motor nucleus (mVp2) and the facial motor nucleus (mVII). Although in Nissl preparations only the mVm could be distinguished from the rest of the nucleus, the boundaries of the other 3 components were clearly demarcated in HRP preparations. Intramuscular injections into two representative antagonistic jaw muscles revealed that there was no apparent topological organization of the neurons pertaining to the opening and closing muscles in the mVm and mVp1, but both antagonistic muscles were innervated bilaterally. Although the hagfish does possess a cartilaginous jaw, the organization pattern of the motor nuclei of the jaw muscles seems to be the most primitive of all living vertebrates.