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991.
HBV、TB合并感染时抗TB治疗对肝功能的影响 总被引:1,自引:0,他引:1
目的:探讨乙型肝炎病毒(HBV)、结核(TB)杆菌合并感染时抗TB药物所致肝损伤的临床及组织学特点。方法:单纯TB感染者45例,TB合并HBV感染者35例,前4月均服用异烟肼、利福平、吡嗪酰胺、乙胺丁醇,后2月服用异烟肼、利福平。每2~4周复查肝功能、HBV标记物、T细胞亚群等指标,部分患者进行了肝穿刺病理检查。结果:TB HBV组肝功能异常发生率为34.3%,较单纯TB组高,发生时间较单纯TB组早半月,发生平均年龄小8岁;谷丙转氨酶水平、肝组织学炎症积分均较TB组高(P<0.05);肝功能异常者中80%为HBeAb阳性,T细胞免疫功能紊乱较重,CD4 细胞明显减少(P<0.05)。结论:HBV、TB合并感染时,抗TB药物的肝毒性增强,治疗过程中应及时复查肝功能。 相似文献
992.
Dr. F. X. Roux L. Merienne B. Leriche S. Lucerna B. Turak B. Devaux J. P. Chodkiewicz 《Lasers in medical science》1992,7(1-4):121-126
The authors present their first experience with laser interstitial thermotherapy, (ITT). Four patients with deep-seated non-infiltrative
benign tumours (three astrocytomas, one oligodendrocytoma) underwent ITT. Previously, a stereotactic procedure had been performed
to determine the exact location of the tumour, its spatial configuration and its histological diagnosis. The MRI controls
confirmed the efficacy of hyperthermia on the tumour tissues. The authors discuss the possible ITT mechanisms. The indications
of such laser ITT in neurosurgery should be enlarged to malignant tumours (gliomas, metastases) and to certain hypophyseal
adenomas. 相似文献
993.
Beryce W. MacLennan Ph.D. FAPA DFAGPA 《Journal of Child and Adolescent Group Therapy》1994,4(4):243-250
Many inner-city children, living in resource-poor violent communities, have low self esteem, deficient social skills and do
not know how to prevent and cope with provocation and conflict. A group therapy model is described for assisting elementary
school children deal with these problems. Groups were led by volunteer mental health professionals in two inner-city elementary
schools. 相似文献
994.
Y Kaymak† N lter‡ 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1256-1260
BACKGROUND: Isotretinoin is the only drug that affects almost all factors in acne pathogenesis. Recently, its use for the treatment of chronic mild or moderate acne unresponsive to long-term antibiotic therapy, and with a tendency to cause scarring and leading to negative psychological effects, has became popular. The aim of the study was to investigate the effectiveness of intermittent isotretinoin treatment in mild or moderate acne. METHODS: Sixty patients with mild or moderate acne localized to the face were enrolled in the study. The treatment regimen consisted of isotretinoin, 0.5-0.75 mg/kg per day, applied for 1 week every 4 weeks for a total period of 6 months, according to the degree of acne and number of inflammatory lesions. RESULTS: Forty-one (68.3%) of the 60 patients completed the 6-month therapy. At the end of the treatment complete improvement was observed in 34 patients (82.9%) out of 41. All adverse effects were mild and discontinuation of the treatment was not necessary. CONCLUSION: Intermittent isotretinoin treatment was found to be a safe and effective choice for patients with mild or moderate acne. 相似文献
995.
目的:探讨联合应用成纤维细胞介导IL2和IL3的基因疗法对骨髓移植(BMT)后荷瘤小鼠抗肿瘤作用的效果及机理。方法:将分别转染IL2基因及IL3基因的NIH3T3细胞以单独或联合方式移植至BMT的荷瘤小鼠腹腔内8d后,取出小鼠骨髓细胞检测杀伤活性的变化以及IL2受体的表达,并观察荷瘤小鼠的存活期。结果:IL3基因治疗虽然可加速BMT后造血重建过程,但对骨髓细胞的NK、LAK活性具有一定的抑制作用;IL2基因治疗可明显提高骨髓细胞的杀伤活性;联合应用基因治疗后荷瘤小鼠骨髓NK、LAK活性及骨髓细胞CD25表达升高,明显延长大剂量化疗后接受BMT的荷瘤小鼠的存活期。结论:联合应用IL2和IL3的基因疗法能协同提高骨髓细胞IL2受体表达水平,提高骨髓细胞毒活性,增强BMT后的抗肿瘤效果。 相似文献
996.
应用戊二醛、甲醛甲酚消毒感染根管各80例,观察其细菌学培养情况,结果表明戊二醛消毒根管后细菌培养阳性率4%,甲醛甲酚消毒根管后细菌培养阳性率为18%,说明戊二醛对感染根管的消毒作用显著优于甲醛甲酚消毒剂。 相似文献
997.
Elimination of bacteria on different implant surfaces through photosensitization and soft laser. An in vitro study. 总被引:2,自引:0,他引:2
Robert Haas Orhun Dörtbudak Nikoletta Mensdorffpouilly Georg Mailath 《Clinical oral implants research》1997,8(4):249-254
Microbiologic examinations of implants have shown that certain micro‐organisms described as periodontal pathogens may have an influence on the development and the progression of peri‐implant disease. This experimental study aimed to examine the bactericidal effect of irradiation with a soft laser on bacteria associated with peri‐implantitis following exposure to a photo‐sensitizing substance. Platelets made of commercially pure titanium, either with a machined surface or with a hydroxyapatite or plasma‐flame‐sprayed surface or with a corundum‐blasted and etched surface, were incubated with a pure suspension of Actinobacillus actinomyetemcomitans or Porphyromonas gingivalis or Prevotella intermedia. The surfaces were then treated with a toluidine blue solution and irradiated with a diode soft laser with a wave length of 905 nm for 1 min. None of the smears obtained from the thus treated surfaces showed bacterial growth, whereas the smears obtained from surfaces that had been subjected to only one type of treatment showed unchanged growth of every target organism tested ( P <0.0006). Electron microscopic inspection of the thus treated platelets revealed that combined dye/laser treatment resulted in the destruction of bacterial cells. The present in vitro results indicate that lethal photosensitization may be of use for treatment of peri‐implantitis. 相似文献
998.
牙片中骨量与灰度的关系及灰阶的改进 总被引:2,自引:0,他引:2
本文对较小厚度范围内颌骨、金属铝在X片上的灰度水平与厚度变化关系进行了探讨,提出在数字减影牙片中以金属铝制成均匀楔形灰阶,代替传统金箔制成的台阶式灰阶. 相似文献
999.
J. J. J. de Sonnaville M. Bouma L. P. Colly W. Devillé D. Wijkel R. J. Heine 《Diabetologia》1997,40(11):1334-1340
Summary In primary care it is difficult to treat the growing number of non-insulin-dependent diabetic (NIDDM) patients according
to (inter)national guidelines. A prospective, controlled cohort study was designed to assess the intermediate term (2 years)
effect of structured NIDDM care in general practice with and without ’diabetes service' support on glycaemic control, cardiovascular
risk factors, general well-being and treatment satisfaction. The ’diabetes service', supervised by a diabetologist, included
a patient registration system, consultation facilities of a dietitian and diabetes nurse educator, and protocolized blood
glucose lowering therapy advice which included home blood glucose monitoring and insulin therapy. In the study group (SG;
22 general practices), 350 known NIDDM patients over 40 years of age (206 women; mean age 65.3 ± SD 11.9; diabetes duration
5.9 ± 5.4 years) were followed for 2 years. The control group (CG; 6 general practices) consisted of 68 patients (28 women;
age 64.6 ± 10.3; diabetes duration 6.3 ± 6.4 years). Mean HbA1 c (reference 4.3–6.1 %) fell from 7.4 to 7.0 % in SG and rose from 7.4 to 7.6 % in CG during follow-up (p = 0.004). The percentage of patients with poor control (HbA1 c > 8.5 %) shifted from 21.4 to 11.7 % in SG, but from 23.5 to 27.9 % in CG (p = 0.008). Good control (HbA1 c < 7.0 %) was achieved in 54.3 % (SG; at entry 43.4 %) and 44.1 % (CG; at entry 54.4 %) (p = 0.013). Insulin therapy was started in 29.7 % (SG) and 8.8 % (CG) of the patients (p = 0.000) with low risk of severe hypoglycaemia (0.019/patient year). Mean levels of total and HDL-cholesterol (SG), triglycerides
(SG) and diastolic blood pressure (SG + CG) and the percentage of smokers (SG) declined significantly, but the prevalence
of these risk factors remained high. General well-being (SG) did not change during intensified therapy. Treatment satisfaction
(SG) tended to improve. Implementation of structured care, including education and therapeutic advice, results in sustained
good glycaemic control in the majority of NIDDM patients in primary care, with low risk of hypoglycaemia. Lowering cardiovascular
risk requires more than reporting results and referral to guidelines. [Diabetologia (1997) 40: 1334–1340]
Received: 5 February 1997 and in revised form: 22 May 1997 相似文献
1000.
Boonen S, Broos P, Dequeker J, Bouillon R (Department of Internal Medicine, Division of Geriatric Medicine, the Arthritis and Metabolic Bone Disease Research Unit, the Department of Traumatology and Emergency Surgery and the Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium). The prevention or treatment of age-related osteoporosis in the elderly by systemic recombinant growth factor therapy (rhIGF-I or rhTGFβ): a perspective (Review). J Intern Med 1997; 242 : 285–90.
Both insulin-like growth factor-I (IGF-I) and transforming growth factor β (TGFβ) have powerful modulatory effects in a variety of tissues. A major target of action is the skeletal system, where they enhance bone formation and decrease matrix degradation, thus playing a part in the maintenance of bone mass. Because of the potent mitogenic effect of these agents on osteoblasts, recombinant IGF-I (rhIGF-I) and recombinant TGFβ (rhTGFβ) have potential as drugs to stimulate bone formation in the prevention and treatment of osteoporosis. Using biochemical markers, subcutaneous rhIGF-I therapy has been shown to increase bone turnover and bone formation in nonosteoporotic older people. However, a corresponding increase in bone mass has not yet been documented nor have there been reports yet on the effects of systemically administered rhTGFβ in humans. Further investigation is required to define the clinical potential of rhIGF-I and rhTGFβ as therapeutic agents in age-related osteoporosis. 相似文献
Both insulin-like growth factor-I (IGF-I) and transforming growth factor β (TGFβ) have powerful modulatory effects in a variety of tissues. A major target of action is the skeletal system, where they enhance bone formation and decrease matrix degradation, thus playing a part in the maintenance of bone mass. Because of the potent mitogenic effect of these agents on osteoblasts, recombinant IGF-I (rhIGF-I) and recombinant TGFβ (rhTGFβ) have potential as drugs to stimulate bone formation in the prevention and treatment of osteoporosis. Using biochemical markers, subcutaneous rhIGF-I therapy has been shown to increase bone turnover and bone formation in nonosteoporotic older people. However, a corresponding increase in bone mass has not yet been documented nor have there been reports yet on the effects of systemically administered rhTGFβ in humans. Further investigation is required to define the clinical potential of rhIGF-I and rhTGFβ as therapeutic agents in age-related osteoporosis. 相似文献