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101.
目的 结合临床资料总结出重型狼疮性肾炎(LN)两种较好的治疗方法.方法 甲基强的松龙(MP)联合环磷酰胺(CTX)的"双冲"方案及足量激素口服或甲基强的松龙冲击联合霉酚酸酯(MMF)的冲击联合方案.结论 作者认为重型LN必须遵循个体化原则,根据病理类型的不同、病情的急缓选择合适的治疗方法. 相似文献
102.
在钯催化的Suzuki交叉偶联反应中,以聚环氧乙烷-甲醇为混合溶剂,反应结束后用正庚烷提取,产物进入非极性相,收率〉90%。催化剂留在极性相,可循环使用多次。 相似文献
103.
某些疾病可能引起暂时性抗原减弱,血清抗体下降而导致血型鉴定困难。聚凝胺技术具有敏感性高、反应快速等优点,对ABO血型的鉴定有辅助作用。我们采用聚凝胺法辅助鉴定ABO血型2例,现报告如下。 相似文献
104.
105.
王建明 《现代中西医结合杂志》2007,16(21):3013-3014
痤疮是青年人群中最常见的一种皮肤病,重度痤疮常因面部出现较多炎性皮疹、囊肿、结节而使容貌受损,极大地影响患者身心健康。本病治疗方法较多,但疗效不满意。2000年以来,笔者应用口服异维A酸联合白花蛇舌草针肌肉注射治疗本病,取得较好效果,现报道如下。 相似文献
106.
107.
目的 观察甲基强的松龙治疗毛细支气管炎的疗效。方法 将毛细支气管炎患儿72例随机分为两组,治疗组35例,应用小剂量甲基强的松龙静滴;对照组37例常规治疗。结果两组在喘憋消失、肺部喘鸣音消失、咳嗽消失、住院天数方面比较,差异有显著性(P〈0.05,P〈0001)。结论 小剂量强的松龙治疗毛细支气管炎疗效确切,安全有效,值得临床推广应用。 相似文献
108.
BACKGROUND: As a non-invasive technique which can provide comprehensive biological information, 1H-magnetic resonance spectroscopy (1H-MRS) may provide valuable reference data for irreversible recovery or reversible changes in ischemic tissue after stroke.
OBJECTIVE: To monitor and evaluate the effect of the urokinase thrombolytic therapy after experimental acute cerebral ischemia by 1H-MRS technology and investigate its adaptability.
DESIGN: Randomly controlled animal study.
SETTINGS: Shenzhen Hospital of Peking University and National Key Laboratory of Pattern and Atom & Molecular Physics, Wuhan Physics and Mathematics Institute, Chinese Academy of Science.
MATERIALS: Eleven healthy adult Sprague-Dawley (SD) rats, weighing 260–300 g and of both genders, were supplied by Experimental Animal Center of Tongji Medical Collage, Huazhong University of Science and Technology [SCXK (e) 2004-007]. 4.7T superconducting nuclear magnetic resonance meter was provided by Brucker Company.
METHODS: The experiment was carried out in Shenzhen Hospital of Peking University and National Key Laboratory of Pattern and Atom & Molecular Physics, Wuhan Physics and Mathematics Institute, Chinese Academy of Science from August 2003 to December 2005. ① The rats were randomly divided into 30-minute self-thrombo-embolism group (n =6) and 60-minute self-thrombo-embolism group (n =5). Six rats in 30-minute self-thrombo-embolism group were occluded with clot embolus for 30 minutes and 5 rats in 60-minute self-thrombo-embolism group were occluded for 60 minutes. 10 000 U/kg urokinase was dissolved in 2 mL saline and the operation lasted for 5 minutes. ② 1H-MRS was performed before thrombolysis and at 3 hours and 24 hours after successful embolization. The metabolic changes of N-acetyl-L-aspartic acid (NAA)/phosphocreatine (PCr) + creatine (Cr), choline phosphate (Cho)/PCr+Cr and lactic acid (Lac)/PCr+Cr in the region of interests were analyzed. ③ The T2W image was conducted 24 hours after the thrombolytic therapy with TR=500 ms and TE=25 ms. ④ The subjects were sacrificed immediately after 1H-MRS and the brain tissues were cut into pieces and stained with HE method; in addition, pathological changes were observed under optic microscope.
MAIN OUTCOME MEASURES: ① Metabolic changes of NAA/PCr+Cr, Cho/PCr+Cr and Lac/PCr+Cr in the region of interests; ② T2W image at 24 hours after the thrombolysis; ③ pathological observation of brain tissue.
RESULTS: Eleven rats were all involved in the final analysis. ① Metabolic changes in the region of interests : In 30-minute self-thrombo-embolism group, the Lac peak emerged immediately after the embolism, but the ischemic zone decreased 3 hours after the thrombolytic therapy (0.252±0.01, 0.603±0.01, P < 0.01). Lac/(PCr+Cr) ratio was 0.290±0.01 at 24 hours after thrombolysis, which was higher than that at 3 hours after thrombolysis (P < 0.01). The NAA/ (PCr+Cr) ratio decreased significantly at 3 hours after the thrombolysis as compared with that before thrombolysis (0.922±0.16, 1.196±0.01, P < 0.05). In 60-minute self-thrombo-embolism group, the Lac/(PCr+Cr) ratio was higher at 3 hours after thrombolysis than that before thrombolysis (0.846±0.12, 0.601±0.11, P < 0.05) and the NAA/(PCr+Cr) decreased at 3 hours after the embolism. Fluctuation of NAA/ (PCr+Cr) ranged from 0.68 to 0.75 before thrombolysis and from 0.71 to 0.75 at 3 hours after thrombolysis. ② T2W image: T2W image showed that 2 subjects in 30-minute self-thrombo-embolism group whose Lac/NAA was higher than 0.7 suffered from intracranial hemorrhage. This meant that the subjects with Lac/NAA > 0.7 were more likely to suffer from intracranial hemorrhage. ③ Histological and morphological examinations: Optic microscope demonstrated that interspace surrounding nerve cells was widened at ischemic center; neurons were swelling; nucleus was stained lightly; pyknosis and mesenchymal edema were mainly observed in lateral cortex of brow and vertex and in lateral part of corpus striatum.
CONCLUSION: ①Compound parameters in ischemic area before thrombolysis should be regarded as an important predicting marker for thrombolytic therapy, effect evaluation and termination. ② 1H-MRS combining with other imaging technique is a detecting way for screening cases who are suitable for thrombolytic therapy. 相似文献
109.
110.
《中国农村医学杂志》2005,3(3):44-55
1 青霉素类抗生素。本类药物可分为:(1)主要作用于革兰阳性细菌的药物,如青霉素(G)、普鲁卡因青霉素、苄星青霉素、青霉素V(苯氧甲基青霉素)。(2)耐青霉素酶青霉素,如甲氧西林(现仅用于药敏试验)、苯唑西林、氯唑西林等。(3)广谱青霉素.抗菌谱除革兰阳性菌外,还包括:①对部分肠杆菌科细菌有抗菌活性者,如氨苄西林、阿莫西林;②对多数革兰阴性杆菌包括铜绿假单胞菌具抗菌活性者,如哌拉西林、阿洛西林、美洛西林。 相似文献