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91.
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93.
5名电离辐射事故患者外周血T细胞T细胞抗原受体、T细胞分化抗原决定簇-3效应的研究 总被引:1,自引:0,他引:1
文中报道了5名事故性急性骨髓型放射病患者照后2.5和3.5年外周血T淋巴细胞T细胞受体(TCR)基因,TCR、T细胞分化抗原决定簇-3(CD_3)表达与TCR/CD_3复合物功能的辐射效应.发现5名患者于照后2.5年,2名(5.2Gy和2.4Gy,55岁)于照后3.5年外周血T细胞应答抗CD3单抗刺激而增殖的能力尚未完全恢复;经同时用IL-2和抗CD_3单抗刺激,增殖能力比单用抗CD_3单抗刺激有所增强;后2名的外周血TCR、CD_3阳性细胞百分率一直低于正常对照和其他患者;并见一患者出现DNA重排杂交带型.本文并从TCR/CD_3在介导T细胞抗原刺激反应中的作用,电离辐射对TCR/CD_3复合物的影响,后果和意义等方面进行了讨论. 相似文献
94.
为获得我食品和膳食中放放射性核素含量并为制定?食品中放射性物质限制浓度标准?提供依据,在1982~1086年问由30个辐射防护单位协作,测定了我过14类(27种)特定食品种22种放射性核素浓度.按我国三种主要膳食食类型.从14个正常本底辐射的省或自治区及三个非正常地区采集样品进行分析测定.估算了这些地区居氏15种放射往核素的年摄人最及所致待积剂量毒量.我国正常本底辐射地区成年男子对这15种核索年总摄入量约为4.2×104Bq,所致总待积剂量当量约为0.43×104Sv.在两个天然放射性较高地区天然放射性核素的年摄入量和所致待积剂量当量比正常本底辐射地区高得多,而在该核工厂周围地区采集的食未明显放射性污染.文章还讨论了各类食品或放射性核素对总待积剂量当量的相对贡献. 相似文献
95.
Iodine-125 interstitial irradiation for cerebral gliomas 总被引:3,自引:0,他引:3
96.
The apparent concentration-effect relationship is the ensemble of many effector units (such as individual cells or channels)
that do not always exhibit a uniform stimulus-effect relationship. This concept is substantiated by many observations of heterogeneity
in receptor-effector populations including hormone secreting cells, response to hormonal stimuli, activity pattern of second
messengers, stimulus-evoked synaptic currents, and single ion channels. The relationship between drug concentration and magnitude
of pharmacologic response is commonly described by the sigmoidalE
max model which was derived from the Hill equation. The sigmoidicity factor (N) in this model is assumed to be a pure mathematical parameter without physiological connotations. This work demonstrates
that the numerical value ofN (measured empirically) is the product of two factors: (i) the degree of heterogeneity of the effector subunits, i.e., the
elemental component that upon drug stimulus contributes its pharmacological effect independently and does not interact with
other subunits (it could range from a single receptor up to a whole tissue), and (ii) value ofN
*—the shape factor of the subunits' concentration-effect relationship. A special case of this approach occurs whenN
*>5, which is an on-off case. HereN is determined by the distribution (density equation) of the subunit values. In case of heterogeneity of the microparameters
of the effector subunits the apparentN will always have a lower value thanN
*. According to this theory it can be concluded that without knowledge of the distribution of the microparameters no mechanistic
interpretation can be deduced from the apparentN value. If in the futureN
* can be determined by theoretical or experimental methods, the distribution function relatingN
* toN can be calculated. The relevance of this theory is increased in view of the progress being made in advanced research techniques
which may enable us to determine the concentration-effect relationship at the level of the individual effector unit. 相似文献
97.
98.
Dr C. J. Whitters T. W. Macfarlane D. Mackenzie H. Moseley R. Strang 《Lasers in medical science》1994,9(4):297-303
Pulsed Nd-YAG laser irradiation of bacteria has been suggested as a possible means of treating contaminated intra-oral sites
although relatively few studies have been conducted. In this investigation, the antimicrobial activity of a pulsed Nd-YAG
laser was assessed in vitro for a range of oral bacteria using several pulse energies and exposure durations. Pure cultures
of each organism were lased in saline suspensions followed by standard colony counting techniques for test and control samples.
Microbial inhibition was found to be organism-dependent and varied with energy dose and pulse energy. For all nine test species
120-mJ laser pulses proved more efficient than 80-mJ pulses, with 99.9% kills compared with around 90% kills after exposure
to 1800 pulses. These killing activity levels compare favourably with those achieved with other lasers in vitro. 相似文献
99.
Heather J. Zar Michael J. Asmus Eugene G. Weinberg 《Pediatric allergy and immunology》2002,13(3):217-222
Inhaled therapy using a metered‐dose inhaler (MDI) with attached spacer has been increasingly recognized as the optimal method for delivering asthma medication for acute attacks and chronic prophylaxis. However, in developing countries the cost and availability of commercially produced spacers limit the use of MDI‐spacer delivery systems. A 500‐ml plastic bottle has been recently adapted to function as a spacer. This article reviews the current data on the efficacy of this bottle‐spacer and discusses its advantages and limitations. It is concluded that a modified 500‐ml plastic bottle is an effective spacer; modification and use of this device should be incorporated into international guidelines for the management of children with asthma. 相似文献
100.
Y. SUZUKI† T. NAKANO† T. OHNO† S. KATO Y. NIIBE S. MORITA & H. TSUJII 《International journal of gynecological cancer》2006,16(1):306-311
The presence of hypoxic cells is one of the major factors affecting resistance against radiation therapy. In the clinical setting, little information exists as to the relationship between intratumoral oxygen partial pressure (pO(2)) and outcome. This study involved 30 consecutive patients with cervical cancer, who were treated with a combination of external and high-dose rate intracavitary irradiation. The pO(2) was measured before radiation therapy and at 9 Gy, using a needle-type polarographic oxygen electrode. The mean intratumoral pO(2) before radiation therapy was 17.3 +/- 10.8 mm Hg. The 3-year local control rates of patients with pO(2)< or = 20 mm Hg and pO(2) > 20 mm Hg before radiation therapy were 52% and 100%, respectively, representing a significant difference (P= 0.035). At 9 Gy, mean intratumoral pO(2) was 23.6 +/- 9.1 mm Hg, a significant increase compared to the value before radiation therapy (P= 0.006). The 3-year local control rates of tumors with pO(2)< or = 20 mm Hg and pO(2) > 20 mm Hg at 9 Gy were 35% and 93%, respectively, representing a significant difference (P= 0.001). The significantly better local control for oxygenated tumors at 9 Gy as well as before radiation therapy indicated that the oxygen effect and reoxygenation by radiation played an important role in local control in radiation therapy for cervical cancer. 相似文献