保肾乙丸对延缓腹膜透析患者残余肾功能的临床观察

本研究对行腹膜透析患者予口服中药保肾乙丸治疗,以观察其对残余肾功能的影响。将54例尿毒症行腹膜透析的患者随机分为两组,透析3个月后,对照组患者尿量(UV)、残余肾功能(RRF)、尿素KT/V、肌酐清除率(Ccr)均较治疗组有明显降低(P<0.01),而治疗组血尿素氮(BUN)、血肌酐(Cr)明显比对照组降低(P<0.01)。     

105例胃癌COX模型预后分析

对105例胃癌死亡病例进行了17个指标及其83个项目的COX模型生存分析，该组病人的中位生存期为9个月，1、3和5年生存率分别为41．9％、5．71％和2．86％。结果显示：分期、治疗、首发症状和病程4项指标与生存最相关；结果提示：对胃癌应早发现、早诊断、早治疗，综合治疗；结果还提示：对首先出现的全身表现和不同病程胃癌的不同生物学行为特征要给予重视。     

天津市区甲状腺癌流行状况调查

目的:描述天津市区甲状腺癌的发病状况、流行趋势并分析影响因素.方法:统计分析1981年1月～2001年12月市区全部甲状腺癌新发病例数据,描述发病情况并根据有关年份人口数,按年龄、性别、病例诊断时间计算发病率,研究各年份的发病变化状况.结果:天津市区甲状腺癌21年新发病例共1 318例,病理类型构成以乳头状癌最为常见.男性中位发病年龄为55岁,女性为49岁,女性明显早于男性.甲状腺癌男性平均发病率为0.938/10万,女性为2.615/10万,女性高于男性.21年来甲状腺癌的发病率呈逐年上升趋势,女性的发病增长幅度高于男性.结论:甲状腺癌的发病率增长较快,提示今后需加强病因学研究和肿瘤相关健康教育并对高危人群进行重点监测和早期防治.     

军字一号系统新药品初试化测试方法研究

在军字一号新药系统数据结构后台和Powerlluilder6．5环境下，用SQL语句进行严密测试药品信息的完整性和一致性的步骤和方法：     

复方解热凝胶溶出度方法研究

目的：建立复方解热凝胶的溶出度标准。方法：采用《中华人民国和国药典》(2000年版)二部附录X溶出度测定第二法，以0.062 mol·L 1盐酸为溶剂，测定复方解热凝胶溶出度。结果：复方解热凝胶溶出度均一性好，累积溶出百分率在30 min内达89.8%；经后差检验，C＝0.000 98，P＝1。结论：该剂型溶出度标准30 min内确定为标示量的85.0%。     

一起副溶血弧菌食物中毒实验报告

目的探讨一起食物中毒的致病原因,为疾病防治提供依据。方法采集剩余食物、病人粪便等样品,进行细菌培养,采用Sensititre半自动微生物分析仪和鉴定板进行菌株鉴定和药敏分析。结果从15份样品中分离到氧化酶阳性菌株,鉴定结果证明所分离的菌株为副溶血弧菌。结论本次食物中毒是由于海产品中的副溶血弧菌污染食物引起的。     

用本体论方法构建国家卫生信息标准基础框架

目的构建国家卫生信息标准基础框架.方法将本体论的方法应用于卫生信息领域,自顶向下构建国家卫生信息标准基础框架.结果①明确了国家卫生信息的范围：4个主域、11个亚域和53构件.②确立了国家卫生信息的数据模型及其层级关系：国家卫生信息数据模型的层级关系从大到小依次为信息框架、承接关系数据模型、概念数据模型、逻辑数据模型;③归纳出数据中的实体类,明确了类间的层级关系：所有的数据按照逻辑关系划分为11个超级实体（super-entities）,即业务因素、事件、费用、支撑条件、位置、参与者角色、参与者特征、结局、卫生服务计划、卫生服务需求、环境因素.根据超级实体表达信息的复杂程度,进一步将其细化为子实体,子子实体等.④确定实体类的属性及与其相关的数据元.结论本体论的方法可以作为构建国家卫生信息标准基础框架的基本技术路线.     

Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats.

Oral treatment with the anti-acne drug Accutane (isotretinoin, 13-cis-retinoic acid) has been associated with suicide ideation and depression. Here, depression-like behaviors (i.e., behavioral despair and anhedonia) were quantified in adult Sprague-Dawley rats gavaged daily beginning at postnatal day (PND) 82 with 13-cis-RA (7.5 or 22.5 mg/kg) or all-trans-retinoic acid (10 or 15 mg/kg ). Tested at PND 130-131 in the Forced Swim Test, 7.5 mg/kg 13-cis-RA marginally decreased immobility and slightly increased climb/struggle durations whereas neither all-trans-retinoic acid group differed from controls. Voluntary saccharin solution (0.03%) intake at PND 102-104 and PND 151-153 was not different from controls in any treated group, although all RA-treated groups had lower intakes. Swim speed in a water maze at PND 180 was similar across groups, indicating no RA-induced differences in physical ability. Open field activity was mildly decreased at PND 91 in 7.5 mg/kg-treated males only, but it was within the control range at PND 119, 147, and 175. Thus, at serum levels similar to those in humans receiving the drug, chronic 13-cis-RA treatment did not severely affect depression-like behaviors in rats. These data do not substantiate the hypothesis of 13-cis-RA-induced depression.     

卵巢上皮癌治疗后远处转移的影响因素

目的：探讨卵巢上皮癌治疗后远处转移的影响因素。方法：对我院1990年1月5日～1995年12月10日收治的40例卵巢上皮癌远处转移者进行回顾分析。结果：初次手术后残余癌灶≤2cm和〉2cm者远处转移率分别为32．5％和60％。全身化疗〈4个疗程和≥4个疗程者转移率分别为62．5％和37．5％，有腹水者和无腹水者的转移率分别为65％和36％P〈0．05。结论：卵巢上皮癌初次治疗后残余癌灶大小、化疗疗程、有恶性腹水者是远处转移的重要因素。     

Evaluation of the ICT Malaria Pf test for rapid post-mortem diagnosis of Plasmodium falciparum malaria in corpses examined for forensic reasons

To test the diagnostic value of a rapid and simple immunochromatographic test (ICT) based on the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) for post-mortem examination, blood samples from 30 consecutive corpses were analysed by ICT and Giemsa-stained blood films. Compared to microscopy, ICT had 100% sensitivity and 100% specificity even after a considerable time had passed between the presumed time of death and testing or after prolonged storage of whole blood samples. The ICT yielded positive results for four travellers who had returned from Kenya and died from Pl. falciparum malaria. The ICT might therefore serve as an additional tool for rapid malaria diagnosis, especially in non-endemic countries where experience with microscopic malaria detection is limited. Received: 5 August 1999 / Received in revised form: 7 October 1999