梅县人群弓形虫感染情况调查

目的了解梅县人群弓形虫感染情况，为预防控制提供科学依据。方法选择重点人群，采用ELISA进行弓形虫抗体IgM、IgG检测。结果共调查504人，人群弓形虫抗体阳性率10．12％，其中IgM阳性率4．56％，IgG阳性率5．56％。男性阳性率11．50％，女性阳性率9．21％，两间无显性差异。屠宰员阳性率26．67％；婚前妇女、孕妇、妇科病人阳性率10．23％；招工体检人员阳性率7．77％；医护人员阳性率5．88％。养猫、狗等宠物的人群阳性率16．33％，不养阳性率8．62％，两间有显差异。结论梅县存在人类弓形虫感染，阳性率高于全国平均阳性率水平。以屠宰员阳性率最高，其次为婚前妇女、孕妇和妇科病人。养猫、狗等宠物的人群阳性率明显高于不养。应加强弓形虫病防治知识的宣传，并引起有关部门的重视。     

Tilt, E.J. and the change of life (1857) - the only work on the subject in the english language

Tilt was the author of the only Enlgish book on the female climacteric published in the 19th century. This short historic sketch is primarily concerned with the evaluation of his work. It only hints at the differences between conditions on the opposite sides of the English Channel which encouraged the expression of climacteric disturbances to the south of it but not to the north. Though Tilt acted as an agent of diffusion for the medical concepts developed in France he had hardly any listeners. During the last quarter of the century, however, conditions changed greatly increasing stress among women. The work of Tilt then supplied a ready mould into which the many nebulous complaints presented by women could be fitted. Ménopause became anglicized to menopause: but though Tilt was “vindicated” he was also forgotten. His style was dated and his treatment out of date. His strong advocacy of sedation is still followed but his pioneering of statistical investigation of the climacteric is largely forgotten. Endocrinal research has made us neglect all that happened before it; examination of the past, its achievements and mistakes, may yet, however, teach us a great deal.     

Psychiatric disorder in Queensland primary schoolchildren

ABSTRACT. Nine hundred and eighty-six 10 and 11-year-old children were screened for psychiatric disorder using a method developed by Rutter for a same-age English population. The prevalence rate was 14%, with rural children showing a lower rate (10%) than urban (15%), and metropolitan (18%). Comparisons between Australian and English children suggest a higher rate of disorder among the former; significantly so in the case of girls (p<.02), with a significant increase in emotional disorder among boys (p<.02), and an increase in conduct disorder among girls but not at a level of statistical significance. The results on teacher questionnaires alone showed a prevalence rate and distribution very comparable to the English study. These findings are discussed in the light of cultural differences and changing social attitudes.     

Miliary tuberculosis in a patient with Epstein-Barr virus-associated angioimmunoblastic lymphadenopathy

 A 74-year-old woman developed angioimmunoblastic lymphadenopathy (AILD) with involvement of intra-abdominal and retroperitoneal lymph nodes. Southern blot analysis showed germline configuration of the JH genes and an oligoclonal pattern of the TcRβ genes. The immunoblasts were of B-cell phenotype and often expressed the CD30 antigen and the latent membrane protein 1 (LMP1) oncogene. Six nonsilent point mutations were identified near the 3′ end of the LMP1 gene, leading to a cluster of six amino acid changes within a protein domain needed for maximal NF-κB stimulation. After a clinical remission of 8 months the patient relapsed with generalized lymphadenopathy and died secondary to tuberculosis. The oligoclonal rearrangements of the TcRβ genes may reflect an unsuccessful cellular immune response to Mycobacterium tuberculosis or an HLA-restricted T-cell response to B-immunoblasts expressing mutated viral antigens. A positive percutaneous tuberculin test observed 6 months prior to the onset of AILD is in favor of the first possibility. Received: 9 October 1995 / Accepted: 30 January 1996     

双黄连粉针剂不良反应117例分析

本文报道双黄连粉针剂所致不良反应117例共155例次反应在性别、年龄、发生时间和类型上的分布与特点。其不良反应无性别、年龄上的差异，发生时间集中于60min以内（占65．3％）。在类型上，变态反应占76．77％（其中皮肤反应49．68％，过敏性休克7．74％，过敏性哮喘和血管神经性水肿均为7．09％，药物热5．16％），消化系统反应16．13％，血管炎2．58％，其它反应4．51％。分析了其不良反应发生的机理和预防方法。     

ras癌基因第12密码子点突变和胃癌患者预后关系的研究

对福尔马林固定，石蜡包埋的胃癌组织使用移聚酶链式反应－限制性片段长度多态性（简称ＰＣＲ－ＲＦＬＰ）技术同时进行ｃ－Ｈａ－ｒａｓ基因第１２位和６１位，Ｎ－ｒａｓ基因第１２位，ｋ－ｒａｓ第１２位和１３位密码子点突变的研究，发现３３．３％（１４／４２），的胃癌有ｃ－Ｈａ－ｒａｓ基因第１２位密码子的点突变；４．８％（２／４２）的病例有ｋ－ｒａｓ基因第１２位密码子的点突变，点突变的发生与患者的预后，淋巴结转     

白血病患儿家长心理卫生状况调查

目的研究白血病患儿家长的心理状态。方法应用ＳＣＬ－９０量表检测白血病患儿家长的心理状态。结果白血病患儿家长存在着多种心理障碍，强迫、抑郁、焦虑三项因子得分显著高于正常人群常模。短病程组（病程〈６个月）家长焦虑、抑郁因子得分较长病程组（病程＞６个月）家长为高（Ｐ〈０．０１）。结论白血病患儿患病期间，特别是在患儿确诊初期，应注意其家长心理状态。提高家长的心理承受能力有助于稳定患儿情绪、提高医疗效果。     

Nephrogenic diabetes insipidus: identification of the genetic defect

Congenital nephrogenic diabetes insipidus (NDI) is an X-linked inherited disorder characterized by renal resistance to the antidiuretic hormonal action of arginine vasopressin. The disease gene has been assigned to the subtelomeric region of the X chromosome long arm by demonstrating close linkage between NDI and several X-chromosomal DNA markers. The finding of closely linked genetic markers is useful in the diagnosis of NDI. Receptor studies in patients have indicated that NDI might be due to the absence or an abnormality of the adenylate cyclase-bound vasopressin type 2 receptor. This assumption was supported by the discovery of functional vasopressin V2 receptor activity in somatic cell hybrid cell lines that carried at least the distal part of the human X chromosome long arm. Definite evidence for a V2 receptor defect being the cause of NDI was found in a recent study demonstrating point mutations in the V2 receptor gene from affected individuals. Direct mutation analysis is now applicable for accurate carrier detection and early (prenatal) diagnosis.