救坤丹治疗子宫发育不良药理学研究

ＪＫＤ对醋酸致小鼠疼痛反应和缩宫素致小鼠痛经均有明显抑制作用，能使性未成熟小鼠子宫湿重和子宫系数增加。ＪＫＤ由阴道给药吸收，作用于子宫，可以通过镇药、增加子宫肌肉发育发挥治疗作用，即如中医认为有“补肾气，填精血，化寒积，破瘀血”之功效     

Tamoxifen and the female genital tract

Ugwumadu AHN, Carmichael P, Neven P. Tamoxifen and the female genital tract. Int J Gynecol Cancer 1998; 8 : 6–15.
Tamoxifen was originally developed by Imperial Chemical Industries (England) (ICI) in 1966 as an anti-estrogenic contraceptive. Ironically, it found a role in the treatment of anovulatory infertility, but its most important application to date is in adjuvant hormonotherapy for breast cancer. Tamoxifen has a complex and poorly understood mix of estrogenic and anti-estrogenic properties with variable and contrasting effects on hormone-sensitive target tissues, such as the endometrium. This article reviews the gynecologic lesions associated with tamoxifen therapy and discusses the merits and acceptability of endometrial surveillance tests and the role of progestogens.     

复方黄芩药效学研究Ⅰ

目的：观察复方黄芩对妊娠小鼠、正常小鼠离体子宫平滑肌的影响。方法：采用离体子宫平滑肌标本运动的实验方法。结果：复方黄芩能降低怀孕与正常小鼠离体子宫收缩力，在20，30min作用最明显；复方黄芩也能降低缩宫素诱导的子宫收缩作用，在20，30min作用最明显。结论：复方黄苓对小鼠的离体子宫有松弛作用。     

液基细胞薄层涂片阴道镜对早期子宫颈癌筛查临床与流调应用研究

目的 :探讨液基细胞薄层涂片 ( TCT)、阴道镜合用对早期子宫颈癌及癌前病变筛查的可行性。方法 :以广东省东莞市长安医院妇科就诊的患者作为筛查人群 ,选择从未进行 TCT、阴道镜及 HPV等检查 ,且均有性生活和非孕期妇女 (年龄不限 )共计 2 5 14例 ,其中本地户籍 12 9例 ( 5 .1% ) ,外地户籍 2 385例 ( 94 .9% )。以病理组织学为金标准 ,结合 HPV- DNA分子生物学诊断技术 ,评价 TCT、阴道镜检查的诊断价值。结果 :该人群现患率 :HSIL (高度鳞状上皮内瘤变 )为 1.4 % ( 34/2 5 14 ) ;SCC(鳞状细胞癌 )为 0 .3% ( 7/ 2 5 14 ) ;平均年龄分别为 33.6和 38.1;人群平均初次性交年龄、性伴数、孕次、产次分别为 2 1.5、 3.2、 4 .8、 2 .3;从事宾馆娱乐美容业占 6 7.3%、家庭妇女占 12 .0 % ,3种方法的敏感度、特异度、阳性预测值、阴性预测值分别为 HPV (阳性≥ 1.0 pg/ ml) ( 0 .96 7,0 .84 4 ,0 .2 2 0 ,0 .998) ;TCT (≥ L SIL 为阳性 ) ( 0 .86 1,0 .95 9,0 .5 77,0 .993) ;阴道镜检查 (≥ CIN 为阳性 ) ( 0 .898,0 .6 89,0 .134,0 .993)。结论 :1该患病人群符合子宫颈癌及癌前病变的流行病学特点 ,因此 ,在开放地区开展早期子宫颈癌及癌前病变筛查有着重要的现实意义。 2 TCT制片效果优良 ,敏感度和特异?     

同种异基因大鼠子宫移植细胞因子表达的研究

目的研究大鼠子宫移植中γ干扰素(IFNγ)、转化生长因子β1(TGFβ1)和白细胞介素-10(IL-10)的表达及其与排斥反应的关系。方法建立大鼠(SD→W istar)子宫异位移植模型,分为正常子宫对照组、同基因子宫移植组和异基因子宫移植组。各组大鼠分别于术后第2~6天切取移植物进行病理学检查、实时荧光定量PCR检测细胞因子mRNA表达。结果移植后第3天,异基因组组织病理表现出排斥反应并进行性加重;同基因组移植子宫无排斥现象;与对照组相比,同基因组中3种细胞因子mRNA表达均无明显差异(P>0.05);与对照组和同基因组相比,异基因组中除TGFβ1移植后第3天表达无明显差异(P>0.05),其余细胞因子均明显升高(P<0.01)。3种细胞因子表达于移植后第4或第5天达到高峰(P<0.01);IFNγ升高幅度为IL-10的4倍,TGFβ1的16倍。结论细胞因子IFNγ、TGFβ1、IL-10在SD→W istar大鼠子宫移植的急性排斥反应中有一定作用,其中以IFNγ的作用最为明显。     

性激素对雌性大鼠膀胱和子宫结构的影响

目的 性激素对女性泌尿生殖系统有重要作用,本研究就性激素对雌性大鼠子宫和膀胱结构的影响进行比较.方法 50只成年雌性大鼠分成5组:假手术组(SHAM)、单纯卵巢切除组(OVX)、卵巢切除 雌激素组(OVX E)、卵巢切除 孕激素组(OVX P)、卵巢切除 雄激素组(OVX T),除假手术组外其余均予以去势手术,且后三组分别给予苯甲酸雌二醇1 mg/kg,黄体酮1 mg/kg,丙酸睾酮3 mg/kg,隔日肌注,四周后处死,光镜下观察子宫和膀胱形态学变化.结果 卵巢切除后子宫肌层、内膜萎缩明显,膀胱壁与子宫肌层的变化类似.补充雌激素和雄激素均可使膀胱重量和膀胱壁厚度明显增加,孕激素对膀胱的作用不明显.结论 雌激素和雄激素均能促进子宫肌层和膀胱逼尿肌增生.     

超声对剖宫产子宫复旧后检查的分析

目的:对剖宫产手术1年后的子宫超声改变进行分析。方法:对有剖宫产手术史者在子宫复旧后进行超声追踪检查。结果:分析300例有剖宫产手术史的患者和30例自然分娩产妇的子宫超声检查结果,发现术后患者与自然分娩产妇的子宫峡部长度有显著差别(P<0.05),其中25%<0.01,20%的患者子宫出现瘢痕团块。结论:在超声检查时应多询问病史,结合临床,避免误诊,尽量自然分娩;术后进行适当运动可减少并发症。     

宫腔镜电切术治疗子宫粘膜下肌瘤及发生TURP综合征分析

目的:探讨宫腔镜电切术(TCRM)治疗子宫粘膜下肌瘤的价值和发生经尿道前列腺切除TURP综合征的诱发因素以及并发症的预防措施。方法:对2001年1月~2005年11月期间采用TCRM治疗子宫粘膜下肌瘤80例及发生并发症1例进行临床分析。结果:80例中77例在B超监护下完成手术,3例在腹腔镜监护下手术,切除粘膜下肌瘤90个,0型45个,Ⅰ型37个,Ⅱ型8个,肌瘤重量2~100g,(18·6±14·8)g,手术时间10~60min,(29·9±11·3)min,失血量5~50ml,(20·1±9·1)ml,1例发生TURP综合征,经积极抢救治疗后痊愈。术后随访所有病人,月经量均明显减少,1例术后4年因多发性子宫肌瘤行全子宫切除术。结论:充分做好术前准备,做好各项预防措施,TCRM术是1种安全、有效的方法。     

A review of the pathology and management of uterine papillary serous carcinoma and correlation with outcome

Uterine papillary serous carcinoma (UPSC) accounts for 10% of endometrial carcinomas but a higher proportion of deaths due to its aggressive nature and poor response to chemotherapy and radiotherapy. In order to add to the knowledge of UPSC in the literature and to review our local practices, we examined the pathology, medical records, and management of all cases of UPSC (67 patients) treated in South East Scotland over a 10-year period and also evaluated the prognostic significance of the percentage of UPSC in endometrial pipelle and hysterectomy specimens. Although only 63% of initial diagnostic biopsies were reported to contain UPSC, rereview of the cases revealed UPSC in 98.5% of the preoperative biopsies. The percentage of UPSC in the tumors did not affect the outcome. Stage, positive omentum, and treatment with external-beam +/- intracavitary radiotherapy were significantly correlated with overall survival and progression-free survival by univariate analysis, but only stage (P < 0.01) was correlated with outcome on multivariate analysis. Chemotherapy did not affect outcome. UPSC may be difficult to diagnose in preoperative biopsies, particularly when present as part of a mixed tumor. Even a small percentage of UPSC in a diagnostic biopsy or hysterectomy specimen is correlated with a poor prognosis. This study emphasizes the need of a cooperative, prospective study on this distinct uterine carcinoma.