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81.
Age, hematopoietic growth factors, cyclosporin A, mode of bone marrow transplantation (BMT) (autologous, allogeneic-related,
unrelated), and underlying disease were assessed as potential risk factors for capillary leakage syndrome (CLS) in 96 patients
after BMT. CLS was defined as unexplained weight gain of >3% within 24 h and nonresponsiveness to furosemide. CLS occurred
in 9/21 patients after unrelated compared with 2/33 after allogeneic-related BMT (p=0.0017) for hematopoietic disorders (n=54) and in 6/7 patients after allogeneic-related compared with 3/35 after autologous BMT (p=0.0001) for solid tumors (n=42). Hematopoietic growth factors and cyclosporin A were no signficant risk factors on their own. We conclude that unrelated
BMTs or high-intensity conditioning regimens used in combination with allogeneic-related BMT are the main risk factors for
CLS.
Received: 6 January 1997 / Accepted: 10 March 1997 相似文献
82.
H. D. Mennel D. Hellwig H. Simon 《Journal of cancer research and clinical oncology》1986,112(3):240-244
Summary Four tumors of the spinal cord were induced with ethylnitrosourea in rats by transplacental administration and transplanted into the brains of animals of the same strain. One of these intracerebrally grafted tumor lines (G-XIII) was followed up over the first 10 passages and treated with CCNU and other alkylating drugs. The results were compared with findings in an earlier established line (G-XII) in passage 12 and 59, which in the first instance was sensitive to CCNU. The CCNU application prolonged survival in treated animals in various treatment schedules in the first 10 intracerebrally grafted generations of the tumor up to 59%. Induction times of tumors became increasingly shorter. The susceptibility of early passages was similar in both lines. Its loss in late passages went together with diffuse growth of the tumor and reticulin fiber production. In addition, glial fibrillary acid protein expression and formation of intermediate filaments in perivascular tumor cells was lost. 相似文献
83.
Conventional therapy for brain tumors, consisting of neurosurgical intervention and radiotherapy, has not resulted in the successes achievable in other childhood malignancies. The role of adjuvant chemotherapy, well defined in many childhood cancers, has not yet contributed significantly to the treatment of children with brain tumors. Chemotherapy of recurrent tumors has produced regressions but no cures. The most active agents identified to date in the treatment of recurrent posterior fossa tumors include cisplatinum, cyclophosphamide and methotrexate. Future efforts will need to focus on the rational selection of drugs for study in limited agent histology-stratified phase II trials, with advancement of active agents into large randomized phase III adjuvant therapy trials. 相似文献
84.
Primary breast lymphoma. 总被引:2,自引:0,他引:2
Primary breast lymphoma (PBL) is a rare tumor of the breast. Three cases of PBL are being described. All three cases achieved remission following biopsy, chemotherapy, and/or radiotherapy. The literature is extensively reviewed with emphasis on true incidence of PBL and survival rates. 相似文献
85.
应用体视学方法对卵巢浆液性肿瘤进行研究,从定量的角度对卵巢良性、交界性及恶性肿瘤的五项指标进行比较,包括(1)细胞核长短轴之比;(2)结缔组织间质与上皮细胞体积密度之比;(3)细胞核与细胞浆体积密度之比(核浆比);(4)细胞核平均直径;(5)乳头的上皮厚度。结果表明恶性肿瘤核浆体积密度比明显高于交界性及良性肿瘤(p<0.01);恶性肿瘤结缔组织间质与上皮细胞体积密度之比明显小于交界性及良性肿瘤(P<0.01)。 相似文献
86.
S. H. Kim J. W. Milsom J. M. Church K. A. Ludwig A. Garcia-Ruiz J. Okuda V. W. Fazio 《Surgical endoscopy》1997,11(10):1013-1016
Background: Because of the inability to palpate colonic tumors during laparoscopy, their location must be precisely identified before
resection is undertaken.
Method: A retrospective study was performed of 58 patients in order to be able to describe our methods of tumor localization for
laparoscopic colorectal operations and to review their effectiveness.
Results: In all patients, the entire colon was examined preoperatively by colonoscopy. In one patient, preoperative colonoscopic localization
was inaccurate. In 31 patients, tumors were easily detectable at surgery. In five patients with the tumor in the right colon,
even though the lesion was not detectable at surgery, right colectomy was performed without marking because preoperative colonoscopy
reliably identified the lesion adjacent to the ileocecal valve. Twenty-two patients required some type of procedure to localize
the tumor. The procedures and their problems were as follows: preoperative tattoo (five)—tattoo not visualized (one); intraoperative
colonoscopy alone (six), combined with intraoperative tattoo (four) or clip (three)—poor operative exposure due to bowel distension
(nine), hard to see the clip (three), dislodged clip (two), inadequate resection margin (one); intraoperative proctoscopy
alone (two), combined with laparoscopic stitch (two)—no problems. In no patient was tumor present at a resection line and
in no patient was the wrong segment resected.
Conclusions: Reliable preoperative identification of the tumor adjacent to the ileocecal valve can permit right colectomy without marking.
Lesions in the upper rectum can be approached via intraoperative proctoscopy ± suture placement. If the surgeon anticipates
intraoperative localization may be difficult, lesions other than rectal or cecal ones should probably be marked by preoperative
tattooing. Further studies regarding the technique of tattooing are warranted.
Received: 18 July 1996/Accepted: 10 March 1997 相似文献
87.
在体诱导鼠脑皮层扩散性抑制研究 总被引:1,自引:0,他引:1
目的用KCl和针刺分别在鼠脑诱导皮层扩散性抑制(CSD),研究其在体成像和电生理特点。方法用针刺(n=10)和KCl(n=10)诱导鼠脑CSD,并用NaCl作对照(n=5),电生理记录和光学成像来描记CSD的产生与传播,并分析其特点。结果单次针刺可诱导一组同心圆样扩散波,KCl诱导多组不规则弧形扩散波,两者均伴随去极化电位的变化,且两者电位的变化无统计学差异(P〈0.05),在对照组没有这一现象的产生。结论KCl和针刺均可在体诱导鼠脑CSD,并通过光学成象(OISI)直接观测CSD的产生发展,与电生理观测结果一致,为进一步研究CSD的发生机制及其可能的作用提供了一种有效手段。 相似文献
88.
89.
本文应用彩色多普勒血流显像技术对40例肺肿瘤患者进行研究。全部病例均经手术及病理证实。结果表明:肺恶性肿瘤的内部及周边血流丰富,搏动指数(PI)和阻力指数(RI)低于肺良性肿瘤。因此,通过观察肺肿瘤的血流丰富程度及PI(界值<1),RI(界值<0.5).可做为辨别肺恶性肿瘤的参考条件。 相似文献
90.