上海市嘉定区贫困精神病人药物治疗情况调查报告

目的调查了解社区精神病人免费服药情况。方法通过对400名社区贫困精神病人随访,比较实行免费药物治疗前后的2年(2004年和2005年)中,在服药依从性、病情稳定情况、劳动能力以及因病所致的经济损失情况的变化,分析实行免费服药后的效果。结果在400例患者中能按医嘱服药的人数从前1年的270例,提高到346例,增加了22%;同时间断服药的患者从前1年的98例,减少到37例,下降了62%;不服药的患者从前1年的32例,减少到17例,不服药率下降了47%。复发率下降了10%。无劳动力的患者下降了4%。误工费用和因病所花费的门诊医药费的损失下降了91%。结论精神病患者需要正规的药物治疗和康复治疗。尤其是贫困精神病患者,更需要政府提供有效和必要的帮助。     

固相板酶免法测定人血清游离三碘甲状腺原氨酸

目的 :探讨游离三碘甲状腺原氨酸 (FT3)的酶免疫测定法对于诊断甲状腺功能亢进和监测甲状腺激素补充治疗效果及预后情况的重要意义。方法 :采用聚苯乙烯96孔板作为固相载体 ,利用亲和纯化的兔抗T3 抗体和T3 - β-半乳糖苷酶标记物 ,建立了固相板竞争法。结果 :可测范围为0.48～45.0ng/L ,灵敏度0.13ng/L ,平均批内变异系数为 (n=20)6.4 % ,平均批间变异系数为 (n=8)12.4% ,正常参考范围4.14±0.97ng/L。正常人与甲亢病人能明显分开。结论 :酶免法测定血清FT3,其灵敏度、精密度均达到放免水平 ,且可避免同位素污染     

Recurrent venous thrombosis following free flap surgery: The role of heparin-induced thrombocytopenia

Complications following free tissue transfer have been well established in the literature. Common and rare causes of free flap failure must be addressed by the treating surgeon when microvascular patency is threatened. With the evolution and prevalence of microsurgery, ‘rare’ causes of free flap failure will become increasingly frequent. A high index of suspicion must be established in patients with multiple failed operative interventions. A case of recurrent free flap failure secondary to heparin-induced thrombocytopenia is presented in a patient with a history of squamous cell carcinoma of the floor of the mouth, and a long-standing history of alcohol and tobacco consumption.     

大气颗粒物健康效应生物学机制研究进展

大量流行病学研究发现，大气颗粒物的污染水平与心肺系统疾病的超额发病、死亡存在密切关联，但其毒理学机制尚未阐明。本文对近年来大气颗粒物毒理学研究进行综述，包括大气颗粒物对呼吸系统、心血管系统及神经系统的毒性作用，并对氧化应激损伤、细胞钙稳态失衡及激活关键转录因子等分子毒理学机制进行了初步的阐述。     

牛磺酸对应激大鼠心肌损伤的保护机制

以异丙肾上腺素诱导的大鼠应激为模型，研究牛磺酸对心肌及血清中自由基系统与游离脂肪酸含量组成的影响。与对照组比较，结果Ｉｓｏ组心肌中ＦＲ、ＬＰＯ、ＣＫ、ＬＤＨ、Ｃ１６：０、Ｃ１８：０、Ｃ１８：１、ＦＦＡ与Ｃ１８：０／ＦＦＡ值显著升高，ＳＯＤ、Ｃ１８：３、Ｃ２０：４ＰＵＦＡ／ＦＦＡ值显著降低；血清中ＬＰＯ、ＣＫ、Ｃ１６：０、Ｃ１８：１、ＦＦＡ值显著升高，Ｃ１８：３、Ｃ２０：４、ＰＵＦＡ／ＦＦＡ及ＳＯＤ值呈下降趋势，牛磺酸对纠正应激引起的上述变化有显著作用，结果提示牛磺酸可通过减少自由基产生，增加抗氧化酶活性来减少脂质过氧化反应，维持细胞膜完整，影响心肌中ＦＦＡ含量及组成，保护心肌免受应激损伤。     

卡托普利对.OH所致异常血流动力学的保护作用

．ＯＨ生成液０．０５ｍｌ．１００ｇ＾－１经胶静脉注入心脏，可使麻醉大鼠的左心室收缩压力、左心室压力与心率乘积、左心室压力上升最大速率和左心室压力下降最大速率明显下降。     

Surgical results of performing R4 gastrectomy for gastric cancer located in the upper third of the stomach

Because gastric cancers located in the upper third of the stomach are difficult to detect at an early stage, the surgical results remain poor. We performed R4 gastrectomy as a radical procedure for 25 patients, involving complete resection of the latero-aortic and interaorticovenous lymph modes above and below the left renal vein, in combination with the ordinary R2 or R3 gastrectomy (the R4 group). These patients were compared with 156 others who underwent R2 gastrectomy alone (the R2 group). There were no significant differences in operation time, blood loss, or the incidence of complications between the two groups; however, when the survival rates of the patients with tumors invading beyond the subserosa were compared, the 5-year survival rate was found to be significantly higher in the R4 group than in the R2 group. Furthermore, in patients with para-aortic nodal involvement, a significant survival advantage was observed in the R4 group, as compared with the R2 group. These results suggest that the R4 gastrectomy is a rational approach for patients with advanced gastric cancer located in the upper third of the stomach.     

用Fura-2测定周围血单个核细胞内游离钙浓度

本文用Fura-2测定了周围血单个核细胞内游离钙浓度，并对有关实验条件进行了探讨。对比研究表明，血标本在4℃保存4小时对测定结果无显著影响，测定标本中单个核细胞数以10~5～10~6/ml为宜。认为测定单个核细胞内游离钙浓度对判断单个核细胞的功能状况有一定帮助。     

超氧化物歧化酶对窒息幼兔脑组织的保护作用

将３２只新西兰种幼兔随机分为对照组、室息组、窒息＋ＳＯＤ组。各组均于实验开始后２４小时心脏取血查ＬＰＯ、ＳＯＤ和ＧＳＨ－Ｐｘ、并取脑组织测脑水分含量。窒息组与对照组比较，血清ＬＰＯ、脑水分含量明显增高、（Ｐ均＜０．０１），血中ＳＯＤ、ＧＳＨ－ＰＸ活性明显降低（Ｐ均＜０．０１），窒息组ＬＰＯ与脑水分含量呈正相关关系。室息＋ＳＯＤ组与室息组比较，血清ＬＰＯ、脑水分含量明显减少（Ｐ均＜０．０１），ＧＳＨ－Ｐｘ活性增高（Ｐ＜０．０１）。提示ＯＦＲ参与了窒息所致脑损伤的病理过程，外源性ＳＯＤ可对室息幼兔脑组织起保护作用。