全文获取类型
收费全文 | 165918篇 |
免费 | 15466篇 |
国内免费 | 7741篇 |
专业分类
耳鼻咽喉 | 2279篇 |
儿科学 | 3811篇 |
妇产科学 | 1817篇 |
基础医学 | 30703篇 |
口腔科学 | 5332篇 |
临床医学 | 12681篇 |
内科学 | 22340篇 |
皮肤病学 | 4433篇 |
神经病学 | 9547篇 |
特种医学 | 3629篇 |
外国民族医学 | 118篇 |
外科学 | 14432篇 |
综合类 | 25676篇 |
现状与发展 | 48篇 |
预防医学 | 4320篇 |
眼科学 | 3473篇 |
药学 | 12701篇 |
26篇 | |
中国医学 | 5052篇 |
肿瘤学 | 26707篇 |
出版年
2024年 | 223篇 |
2023年 | 2290篇 |
2022年 | 2930篇 |
2021年 | 5974篇 |
2020年 | 5303篇 |
2019年 | 5188篇 |
2018年 | 5377篇 |
2017年 | 5668篇 |
2016年 | 5931篇 |
2015年 | 6763篇 |
2014年 | 9835篇 |
2013年 | 10885篇 |
2012年 | 9441篇 |
2011年 | 10583篇 |
2010年 | 8805篇 |
2009年 | 8448篇 |
2008年 | 8905篇 |
2007年 | 9138篇 |
2006年 | 8287篇 |
2005年 | 7607篇 |
2004年 | 6757篇 |
2003年 | 5847篇 |
2002年 | 4794篇 |
2001年 | 4117篇 |
2000年 | 3401篇 |
1999年 | 3067篇 |
1998年 | 2907篇 |
1997年 | 2649篇 |
1996年 | 2379篇 |
1995年 | 2073篇 |
1994年 | 1829篇 |
1993年 | 1525篇 |
1992年 | 1231篇 |
1991年 | 1167篇 |
1990年 | 899篇 |
1989年 | 841篇 |
1988年 | 790篇 |
1987年 | 627篇 |
1986年 | 585篇 |
1985年 | 781篇 |
1984年 | 694篇 |
1983年 | 484篇 |
1982年 | 512篇 |
1981年 | 401篇 |
1980年 | 341篇 |
1979年 | 253篇 |
1978年 | 180篇 |
1977年 | 138篇 |
1976年 | 103篇 |
1975年 | 39篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
《Pathology international》1997,47(11):809-811
The Association of Directors of Anatomic and Surgical Pathology have developed recommendations for the surgical pathology reporting of common malignant tumors. The recommendations for carcinoma of the larynx are reported herein. 相似文献
992.
人重组C3片段通过IL-2自分泌效应对CTLL-2细胞产生促增殖作用 总被引:1,自引:0,他引:1
目的研究补体C3片段的体外生物学活性及其作用机理,进一步探讨C3片段与免疫细胞的关联。方法利用重组DNA技术表达纯化C3活性片段(命名为C33),观察其对IL-2依赖性的小鼠杀伤性T细胞株CTLL-2细胞的促增殖效应,并通过抗体封闭途径和分子杂交技术研究C33作用的机理。结果发现C33蛋白对CTLL-2细胞具有明显的促增殖作用,并呈剂量依赖关系;这一作用能够部分地被抗小鼠CD11b抗体所封闭,能够完全被抗小鼠IL-2抗体所封闭;分子杂交显示C33蛋白能够明显刺激CTLL-2细胞的IL-2mRNA表达。结论人重组C3片段C33可通过IL-2的自分泌效应对CTLL细胞产生促增殖作用,补体受体CR3参与这一作用。 相似文献
993.
采用鼠抗PCNA单克隆抗体,ABC法,对11例正常口腔粘膜及29例口腔鳞癌进行了染色。结果表明:正常粘膜仅在基底层中有少量的PCNA阳性细胞,其阳性分级为1级。而鳞癌阳性分级主要是3~4级,随着组织学分级的升高,PCNA阳性表达率也相应增高。经统计学分析,正常组织与鳞癌之间及鳞癌各级均有非常显著差异(P<001)。提示:PCNA的表达与口腔鳞癌组织学分级有关。 相似文献
994.
目的:提供一种简单可行,易于掌握的体外培养人晶体上皮细胞的方法。方法:用无齿显微镊子将晶体囊膜分离出来,剪碎后直接移至细胞培养瓶中培养,当细胞长出融合后,用胰蛋白酶消化传代。结果:接种培养4天后,可见晶体上皮细胞开始长出,并以贴壁方式生长。结论:用此方法体外培养人晶体上皮细胞,具有简单、快捷、成功率高的优点。眼科学报1997;13:170—172。 相似文献
995.
Alexander Goldberg Ursula Schlötzer-Schrehardt Theo Seiler 《International ophthalmology》1997,21(3):117-120
We report the first case of a unilateral microcysticMeesmann‘s epithelial dystrophy, observed in the left cornea of a 43-year-old
patient. The diagnosis was verified histologically by the unilateral occurrence of a ’peculiar substance‘ within epithelial
cysts and within the cytoplasm of the corneal epithelial cells. In an attempt to resolve thepatient‘s frequent corneal erosions,
we performed an autologous stem cell transplantation from the non-involved right eye. The results are, so far, satisfactory.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
996.
G TamizhMani J.P Dodelet D Guay L Dignard-Bailey 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》1998,444(1):121-125
Four platinum-based catalysts with different catalytic activity for the oxygen reduction reaction have been prepared and tested in polymer fuel cells (PFCs) and in half-cells with H2SO4 and HF electrolytes. The activity results of PFCs at 0.9 V versus RHE (reversible hydrogen electrode) can be mimicked in parallel by the results obtained in HF electrolyte but not by the results obtained in H2SO4 electrolyte. This paper concludes that the pre-screening of a huge number of Pt-based catalysts for the selection of potential catalysts for the PFCs can be carried out by a rapid half-cell technique with a non-adsorbing electrolyte such as HF. 相似文献
997.
The complexity of the RHD and RHCE genes, which is the greatest of all blood group systems, confounds analysis at the molecular level. RH DNA typing was introduced in 1993 and has been applied to prenatal testing. PCR-SSP analysis covering multiple polymorphisms was recently introduced for the screening and initial characterization of partial D. Our objective is to summarize the accrued knowledge relevant to the approaches to Rh phenotype prediction by DNA typing, their possible applications beyond research laboratories and their limitations. The procedures, results and problems encountered are highly detailed. It is recommended that DNA typing comprises an analysis of more than one polymorphism. We discuss future directions and propose a piecemeal approach to improve reliability and cost-efficiency of blood group genotyping that may eventually replace the prevalent serology-based techniques even for many routine tasks. Transfusion medicine is in the unique position of being able to utilize the most extensive phenotype databases available to check and develop genotyping strategies. 相似文献
998.
Takashi Takata Yong Lu Ikuko Ogawa Ming Zhao Zhi Yu Zhou David Mock Hiromasa Nikai 《Pathology international》1998,48(11):877-881
The calcifying odontogenic cyst (COC) presents with diverse hlstologlcal features; thus, several subclasslfl-cations have been proposed. To evaluate the slgnlficance of the various histological features and subtypes of COC from the perspectlve of proliferative activity, the proliferating cell nuclear antigen (PCNA) labellng index (LI; the percentage of positive nuclei) was assessed immunohistochemlcally in 25 cases of COC (21 benign and four malignant). All of the benign cases were of the cystic variety and further subclas-sified into non-proliferative subtype (NPS; four cases); proliferative subtype (PS; eight cases); and COC associated with odontoma (COCaO, nlne cases). The PCNA U of the mallgnant COC (65.2 ± 5.6) was slgnlflcantly higher than that of the benlgn COC (11.6 ± 9.0; P = 0.002). Non-proliferative subtype (6.8 ± 2.8) showed the lowest PCNA LI and PS (17.2 ± 11.2) the highest of among the three subtypes of benign cystic COC (P = 0.028). In nine cases of COCaO, six showed epithelial lining of the non-proliferative type as NPS and the other three had lining wlth proliferative features as PS. The PCNA LI of the latter COCaO group (14.3 ± 6.6) was significantly higher than that of the former (6.1 ± 4.3; P = 0.05), as Seen between PS and NPS. These results demonstrate that PCNA LI is a possible parameter for differentiating mallgnant COC from benign COC and, whatever the subtypes, the proliferative features In the lining are the main factor influencing the prollferatlng actlvity of COC. 相似文献
999.
1000.
4背景
近年,成人急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)诱导完全缓解(complete remission,CR)率可达80%~85%.5年无病生存率(diseases-free survival,DFS)30%-40%。成人ALL预后的改善可能与采用了包括以大剂量甲氨蝶呤联合阿糖胞苷的强烈巩固治疗方案有关.并与根据疾病危险度进行分级分层治疗、根据疾病亚型制定个体化的治疗方案有关。 相似文献