外用重组人表皮生长因子治疗宫颈炎62例疗效分析

目的:总结外用重组人表皮生长因子(金因肽)治疗宫颈糜烂的疗效。方法:分析该院2005年11月～2006年4月治疗病例62例的临床资料,其中已生育病例42例选用宫颈微波凝固治疗后局部喷洒金因肽,一次上药。对于年轻未生育患者20例我们仅采用宫颈病灶匙刮至出血再喷洒金因肽,连续3天上药,1天1次。结果:术后1个月创面愈合显效85.7%,有效14.3%。术后2个月后复诊肉眼观察创面愈合情况,痊愈92.9%,有效7.1%。均无出现无效病例。术后并发症状轻微。结论:疗效明显优于现有的治疗方法,可弥补物理治疗方法的不足,临床应用安全可靠,操作简单,未见术后阴道多量出血病例痊愈后宫颈表面光滑、无瘢痕及瘢痕过度生长。具有治愈率高,修复期短等优点。     

妊娠期宫颈机能不全宫颈缝扎手术时机的探讨

目的:探讨妊娠期因宫颈机能不全行宫颈缝扎术的时机。方法:对我院2000年1月~2004年12月31例因妊娠期宫颈机能不全行宫颈缝扎术的病例的临床资料进行回顾性分析。结果:宫口开大≤2 cm者,手术成功率为81.82%;宫口开大>2 cm者,手术成功率为44.44%,两者间比较,有显著性差异(P<0.05)。孕周为12~18周者,手术成功率为83.33%;孕周>18周者,手术成功率为53.85%,两者差异无显著性(P>0.05)。结论:妊娠期宫颈机能不全缝扎时机与宫口开张有关,与孕周无关。     

Impact of early admission in labor on method of delivery.

OBJECTIVE: The effect of the timing of admission in labor unit on the method of delivery was evaluated in a cohort study. METHOD: Four hundred and sixty six low-risk nulliparous women who were admitted in the labor unit in latent phase (group 1) were compared with 329 parturient women who were admitted in the active phase (group 2) to determine rate of and reasons for cesarean section, cervical dilation at the time of cesarean, and the rate of labor augmentation. RESULT: The number of cesarean deliveries in group 1 was greater than that in the group 2 (301 vs 80, p<0.0001 ). The main reason for cesarean section in group 1 was dystocia, and in 2, fetal distress. The rate of cesarean section in the women who were augmented was greater in group 1 than in group 2 (54% vs 23%, p<0.0001). CONCLUSION: Later admission in labor increases the rate of spontaneous vaginal delivery in low risk nulliparous women.     

人工耳蜗植入"井喷"的判断与术中处理的体会

目的：探讨人工耳蜗植入发生“井喷”的术前判断与术中处理的方法。方法：327例人工耳蜗植入患者术前均行颞骨高分辨CT（HRCT）筛查，并行术前准备及术中处理。结果：11例术前颞骨HRCT显示内耳畸形并发内听道底骨性缺损与耳蜗、前庭相通，术中均有脑脊液喷出，经过术中对植入口的严密封闭，术后未见脑脊液耳鼻漏等并发症的发生。结论：人工耳蜗植入发生“井喷”的原因为内耳与蛛网膜腔有异常开放的通道。术前行颞骨HRCT检查不仅能对内耳畸形的患者作出准确的判断，还能为术中进行正确的处理提供准确的科学依据，从而避免并发症的发生。     

Hologic FD原理浅析及维护

本文浅析了FD(平板探测器)的成像原理,探讨空间分辨率的计算方法,并对DR的使用环境,日常维护、维修作了介绍。     

一种用于测试甚高频B型超声诊断设备纵向分辨力的层状靶

提出一种层状靶的设计，用来评价甚高频B型超声诊断设备的纵向分辨力，并与线状靶测量方法进行了比较。实验结果说明层状靶精度更高，制作更容易，使用更方便，结果更可靠，所以更有潜力用作计量器具和检验工具。     

校正TIMI帧数对急性心肌梗死病人支架成形术后的预后评价

目的：观察急性心肌梗死（AM／）病人成功冠状动脉介入（Percutaneous coronary intervation，PCI）治疗后，校正TIMI帧数（Corrected TIMI Frame Count，CTFC）与其预后的关系。方法：选取成功PCI术后、梗死相关动脉TIMI血流3级的AMI病人123例，测定CTFC，同时观察住院期间不良事件的发生率及随访1年时死亡率。结果：根据CTFC值将病人分为慢、快两组。慢CTFE组住院期间不良事件发生率及随访1年时死亡率明显高于快CTFC组，两组具有显著性差异（P值分别为〈0．01和〈0．05）。结论：CTFC可有效评价成功PCI术后病人近、远期预后，有助于对此类病人进行进一步的危险度分层，以指导治疗。     

非负矩阵因子分解算法解析手性药物重叠峰的HPLC-DAD数据

目的：研究非负矩阵因子分解算法（NMF）用于手性药物HPLC-DAD二维数据解析的可行性及其影响因素。方法：根据化学波谱的基本特征如色谱的单峰性改进NMF算法。考查组分之间色谱分离度、光谱相似程度以及迭代次数对模拟重叠峰解析结果的影响，并将NMF算法应用于实测体系盐酸舍曲林对映异构体体（c／s-1R，4R；c／s-1 S，4S）重叠峰解析。结果：解析结果表明，在色谱严重重叠，光谱相似甚至完全相同时，在合适的迭代次数下，NMF能解析出重叠峰中各单组分的光谱和相应色谱。结论：该种二维数据的解析方法，将为混合样本特别是手性药物混合体系的分析提供新途径。     

Experiences with a compound method for estimating the time since death.

The temperature-based nomogram method for estimation of the time period since death was used at the scene of death as the primary method within a compound method in 72 consecutive cases. The situation and cooling conditions inspected and evaluated by the forensic pathologist at the scene are described as far as necessary to enable handling of the method. A comparison of the estimated period since death with the period determined by the police investigations demonstrates the reliability of the method. There were no contradictions in any of the 60 cases between the period of death estimated by this method and that determined by the police investigations. The criminal investigations were effectively supported in the earliest stages in 11 cases despite the fact that the period estimated was of considerable duration.     

帕珠沙星消旋体的合成及HPLC法拆分

以3-甲基-9,10-二氟-7-氧代-2,3-二氢-7H-吡啶并[1,2,3-de][1,4]苯并噁嗪-6-羧酸乙酯(3)为原料,经亲核取代、脱羧、环合、水解、Hofmann降解可制得帕珠沙星消旋体(1),总收率25.1%.并建立了HPLC法分离1的光学异构体.采用Zorbax C18柱,甲醇-手性溶液(8mmol/L L-苯丙氨酸和4mmol/L硫酸铜混合溶液,用NaOH溶液调至pH3.5)(15:85)为流动相,检测波长为324nm,光学异构体可被良好分离,检测限2ng.