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991.
Philippe Druet 《Journal of immunological methods》1992,150(1-2):177-184
992.
The cerebellar Purkinje cells in the hemizygote of the macular mutant mouse contain numerous abnormal mitochondria which show a marked decrease in cytochrome c oxidase activity. Using histochemical methods we studied the activity of other mitochondrial enzymes, such as NADH diaphorase and succinic dehydrogenase, in the cerebellar cortex of this mutant mouse. Such activities were markedly increased in the Purkinje cells, especially in the soma and stem dendrite, from 10 days after birth in the hemizygote as compared with findings in normal littermates. These results were considered to be due to an increased number of abnormal mitochondria.Supported by the Research Grants nos. 2A-5-03 and 3B-1-04 for Nervous and Mental Disorders from the Ministry of Health and Welfare, and by Grant no. 04670492 of the Ministry of Education of Japanese Government 相似文献
993.
本文用反复静脉注射小剂量牛血清白蛋白复制家兔慢性肾炎,用羊踯躅根治疗。同时,用该药对慢性肾炎病人进行疗效观察。阳性组兔肾小球呈现中至重度颗粒形免疫荧光,肾组织呈明显慢性硬化性肾小球肾炎改变。尿蛋白±~++。治疗组兔及病人治疗后病变及症状均明显减轻或消失。结果提示循环免疫复合物反复沉着可引起兔类似人类的慢性硬化性肾小球肾炎,羊踯躅根对病变有一定的控制和治疗作用,这可能与其抑制免疫发病机制有关。 相似文献
994.
Consecutive survivors of a myocardial infarction from the Southern Hospital, below 70 years of age, were randomized into a Control group (n=276) and a Treatment group (n=279). The latter was openly prescribed the combination of clofibrate and nicotinic acid for serum lipid lowering. Each patient should remain in the study for 5 years and be seen regularly every 4 months at a special IHD outpatient clinic within the hospital. The concentration of serum cholesterol and triglyceride was lowered by 13% and 19%, respectively, in the Treatment group compared to the Control group. Total mortality was 82 cases in the Control group and 61 in the Treatment group, a 26% reduction (p<0.05). For patients above 60 years of age in the Treatment group the reduction in mortality was 28% (p<0.05). IHD mortality was reduced by 36% (p<0.01)in the Treatment group compared to the Control group. The beneficial effect of the serum lipid lowering treatment was related to the serum triglyceride concentration in two ways. First, it only occurred in patients with a triglyceride level >1.5 mmol/l (n=216). Secondly, it was most pronounced in the 44% of the treated patients who had a lowering of the serum triglyceride concentration by 30% or more, and in this subgroup the reduction of IHD mortality was 60% (p<0.01). For serum cholesterol there were no such relations. The difference between serum triglycerides and cholesterol concerning these relations to the treatment outcome may be due to the fact that hypertriglyceridaemia was the most common hyperlipidaemia among our patients, occurring in 50%, while hypercholesterolaemia only occurred in 13 %. Caution should be exercised in the interpretation of the results as the trial was not blind. However, the fact that the decrease in IHD deaths was directly related to the degree of serum triglyceride lowering indicates that it was the drug effect on serum lipids that was reponsible for the beneficial effect of the treatment. 相似文献
995.
新疆奎屯地区口腔粘膜疾病调查 总被引:1,自引:0,他引:1
本文介绍新疆奎屯地区常见口腔粘膜疾病患病情况,其罹患率与上海地区同类调查相比,除白斑外其他病种罹患率均偏高,可能与生活水平偏低或某些全身疾病有关。 相似文献
996.
997.
未研究发现,经热休克处理的大鼠注油酸后,肺组织损伤明显减轻,Western印迹分析显示热休克使大鼠肺组织中HSP70含量明显增多;Northern印迹分析证实此乃由于HSP70mRNA转录增加所致。说明热休克处理使肺组织HSP70基因表达增强;提示热休克反应对大鼠油酸肺的保护作用与肺组织细胞中HSP70基因表达增强及与HSP70增多有关。 相似文献
998.
Ambulatory blood pressure in patients with Parkinson's disease without and with orthostatic hypotension 总被引:1,自引:0,他引:1
Jean-Michel Senard Bernard Chamontin André Rascol Jean-Louis Montastruc 《Clinical autonomic research》1992,2(2):99-104
Non-invasive ambulatory recordings of blood pressure and heart rate were performed using a Spacelabs device during day and night periods in patients with Parkinson's disease with (n = 19) or without orthostatic hypotension (n = 19). In patients with orthostatic hypotension, the average systolic and diastolic blood pressure during the night (137 ± 5/80 ± 3 mmHg) was higher (p < 0.05) than during the day period (121 ± 3/76 ± 2 mmHg). In patients without orthostatic hypotension, a decrease in blood pressure was recorded during the nocturnal period. In patients with orthostatic hypotension, the blood pressure variability was higher (p < 0.05) during the day (systolic: 14.6 ± 1.3%; diastolic: 16.5 ± 1.0%) than during the night (systolic: 9.1 ± 0.8%; diastolic: 10.8 ± 1.1%). The blood pressure load (percentage of values above 140/90 mmHg) during the night was significantly higher than during the day for both systolic (41.2 ± 8.1 vs. 19.6 ± 4.7%) and diastolic blood pressure (24.9 ± 6.9 vs. 16.3 ± 4.9%). There was a decrease in heart rate in both groups during the night. A fall of 25 mmHg or more in systolic blood pressure after meals occurred in ten patients with orthostatic hypotension and in one patient without orthostatic hypotension. These results indicate that orthostatic hypotension in Parkinson's disease is associated with specific modifications of ambulatory blood pressure including loss of circadian rhythm of blood pressure, increased diurnal blood pressure variability and post-prandial hypotension. 相似文献
999.
心脏病患者血清七种元素含量与血压及生化指标的关系 总被引:31,自引:0,他引:31
我们检测了心脏病患者血清微量元素Zn、Cu、Fe和常量元素K、Na、Ca、Mg的含量,并与血压及生化指标作相关分析。结果发现心脏病患者K和Ca/Mg显著低于对照组,而Na、Mg、Zn、Fe和Na/K、Zn/Cu则显著高于对照组。K、Ca/Mg与血压呈负相关,而Na、Zn、Fe、Zn/Cu和Na/K与血压呈正相关;Fe与红细胞压积(Hct)呈正相关;Zn/Cu与Hct、甘油三酯、极低密度脂蛋白均呈正相关,而与高密度脂蛋白呈负相关。 相似文献
1000.
本文对300例肛肠疾病采用CO_2激光治疗,治愈率为94.33%,一次切割完成,不需止血缝合,一般7-15天痊愈,疗效明显优于其它治疗方法。 相似文献