丙戊酸钠血药浓度监测及意义

目的:为临床癫痫患者丙戊酸钠的合理用药提供参考.方法:采用荧光偏振免疫法对143例癫痫患者服用丙戊酸钠进行血药浓度监测,并对结果及疗效进行分析总结.结果:222例次监测结果在有效浓度范围内,占总例次的68.5%,而有6例次血药浓度在正常范围,未能控制癫痫症状,13例次出现毒性反应.血药浓度高于或低于正常浓度有102例次,占31.5%.结论:丙戊酸钠血药浓度监测对合理用药有重要的指导作用,血药浓度个体差异大,临床用药时需个体化给药.     

1997～2003年度我院2823例住院病人地高辛血药浓度监测与分析

目的 　对我院 1997～ 2 0 0 3年度地高辛血药浓度 ( SDC)监测结果进行分析。 方法 　采用荧光偏振免疫法 ( FPIA)测定 SDC。 结果 　 7年监测 SDC2 82 3例 ,其中在治疗窗 ( 0 .5～ 2 .0 ng· ml- 1 )范围内的占监测总数的 64 .3 3 % ;>2 .0 ng· ml- 1 ,约占 11.47% ;<0 .5 ng· ml- 1占2 4.2 %。性别对 SDC无显著影响 ( P>0 .0 5 ) ,年龄对 SDC有显著影响 ( P<0 .0 5 )。 结论 　地高辛血药浓度监测可为临床合理用药提供可靠依据     

耐甲氧西林金黄色葡萄球菌对万古霉素敏感性的监测

目的为了引起广大医务人员高度重视耐甲氧西林金黄色葡萄球菌(MRSA)对万古霉素敏感性的监测,掌握其耐药特性,依据药敏结果合理使用抗菌药物,延缓其耐药性的产生. 方法采用美国Microscan微生物鉴定仪、革兰阳性菌鉴定药敏复合板(PC11),对1998～2000年分离的MRSA对万古霉素敏感性的监测. 结果 1998～2000年分离的MRSA菌株中,有4株对万古霉素敏感性降低,其中1株对万古霉素的MIC=8μg/ml;3株对万古霉素的MIC>16μg/ml. 结论在我院监测中出现1株万古霉素中介敏感金黄色葡萄球菌(VISA);3株万古霉素耐药金黄色葡萄球菌(VRSA),药敏结果显示多重耐药.     

两种噪声强度测定法用于噪声作业岗位卫生学评价的比较

目的　探讨两种不同方法对工作场所的噪声强度进行测定的效果 ,为噪声作业岗位的卫生学评价提供科学依据。方法　选择有噪声作业的 3个场所 ,且噪声是不连续、非稳态噪声 ,分别用瞬时测定方法和等效连续A声级测定方法对噪声强度进行测定。结果　用瞬时测定方法测得 3个工作场所A、B、C的噪声强度分别是 89 6dB(A)、95 3dB(A)和 92 7dB(A) ,3个工作场所的噪声强度都超过国家职业卫生标准。用等效连续A声级方法测得 3个工作场所的噪声强度分别是 83 8dB(A)、92 5dB(A)和 88 7dB(A) ,根据国家职业卫生标准 ,工作场所A噪声强度未超标 ,工作场所B、C噪声强度超标。结论　对于不连续、非稳态噪声 ,用等效连续A声级方法测定噪声强度比瞬时测定方法更科学合理 ,更客观反映劳动者接触噪声的实际情况     

Aorto-Caval Fistula Due to Rupture of Abdominal Aneurysm

Abstract

Two operated cases of aorto-caval fistula due to ruptured abdominal aneurysm are reported. This is a rare and real surgical emergency and is fatal without operation. The classical symptoms of high-output failure occurring simultaneously with the findings of an expansible abdominal mass with thrill and bruit should facilitate clinical diagnosis.     

Starch digestibility modulation significantly improves glycemic variability in type 2 diabetic subjects: A pilot study

Background and aimsIn type 2 diabetes (T2D) patients, the reduction of glycemic variability and postprandial glucose excursions is essential to limit diabetes complications, beyond HbA1c level. This study aimed at determining whether increasing the content of Slowly Digestible Starch (SDS) in T2D patients’ diet could reduce postprandial hyperglycemia and glycemic variability compared with a conventional low-SDS diet.Methods and resultsFor this randomized cross-over pilot study, 8 subjects with T2D consumed a controlled diet for one week, containing starchy products high or low in SDS. Glycemic variability parameters were evaluated using a Continuous Glucose Monitoring System.Glycemic variability was significantly lower during High-SDS diet compared to Low-SDS diet for MAGE (Mean Amplitude of Glycemic Excursions, p < 0.01), SD (Standard Deviation, p < 0.05), and CV (Coefficient of Variation, p < 0.01). The TIR (Time In Range) [140–180 mg/dL[ was significantly higher during High-SDS diet (p < 0.0001) whereas TIRs ≥180 mg/dL were significantly lower during High-SDS diet. Post-meals tAUC (total Area Under the Curve) were significantly lower during High-SDS diet.ConclusionOne week of High-SDS Diet in T2D patients significantly improves glycemic variability and reduces postprandial glycemic excursions. Modulation of starch digestibility in the diet could be used as a simple nutritional tool in T2D patients to improve daily glycemic control.Registration numberin clinicaltrials.gov: NCT 03289494.     

高龄胃癌患者的围术期监测与护理

目的探讨高龄胃癌患者的围术期监测与护理措施。方法对84例高龄胃癌患者临床资料进行回顾性分析,给予围术期监测、常规护理与护理干预。结果 84例高龄胃癌患者有效率高达89.29%,并发症发生率7.14%。结论对高龄胃癌患者给予围术期监测与综合性护理有利于提高其疗效及预后,保障患者生活质量及生命安全。     

Metamemory with ageing in schizophrenia: A first study

The aim was to study metamemory during encoding in older schizophrenia patients. Thirteen older patients were compared to 13 healthy controls. Despite their memory impairment, older schizophrenia patients were able to assess the material accurately. They were not able, however, to adapt their learning time as efficiently as controls.