穴位埋线对颈椎病疗效的影响

目的：探讨穴位埋线、中医汤药和按摩对颈椎病的治疗作用。方法将120例颈椎病患者随机分为穴位埋线组（40例）、中医汤药组（40例）和按摩组（40例）。穴位埋线组通过对颈项部相关穴位埋线进行治疗;中医汤药组以葛根汤加减进行治疗;按摩组是以舒经活血、理筋整复进行治疗。观察颈椎病症状消失时间的长短、愈后在一定时间内有无复发。结果穴位埋线组痊愈率为90％,中医汤药组痊愈率为85％,按摩组痊愈率为75％。穴位埋线组优于中医汤药组和按摩组,并缩短患者的治疗时间、减少患者复发的次数、医疗费用。结论穴位埋线组可以显著改善颈椎病,促进颈椎病的康复。     

大黄贴敷联合复方聚乙二醇电解质散口服对便秘患者肠道准备给药时机的影响

目的探讨大黄贴敷神阙穴和天枢穴联合口服复方聚乙二醇电解质散(PGEP)在便秘患者肠道准备中的给药时机。方法选择行结肠镜检查的便秘患者300例,分3组,各100例。A组检查前1天晚上9点,行中药贴敷神阙穴和天枢穴,检查当天早上5~7点服完PGEP 139.12 g(2 000 ml);B组检查前1天晚上9点行中药贴敷神阙穴和天枢,检查当天上午10~12点服完相同剂量的PGEP;C组检查当天早上5点行中药贴敷神阙穴和天枢穴,早上5~7点服完相同剂量的PGEP。服药后4 h行结肠镜检查。应用Boston肠道准备量表(BBPS)评分,并对肠腔内气泡进行评分,比较3组患者肠道准备有效性、耐受性及安全性。结果 A组的肠镜检查时间(7.25±0.60)min明显短于B组(9.10±0.80)min和C组(10.50±0.55)min;A组的BBPS评分(8.50±0.35)分明显高于B组(7.35±1.25)分和C组(6.65±1.30)分;A组的肠腔内气泡评分(0.25±0.15)分明显低于B组(0.75±0.65)分和C组(0.55±0.50)分;A组肠道准备接受率、再次肠道准备接受率(96.00%、93.00%)明显高于B组(85.00%、70.00%)和C组(90.00%、88.00%);A组的总体不良反应评分(1.45±0.04)分明显低于B组(1.75±0.55)分和C组(1.60±0.25)分。差异均有统计学意义(P0.05)。结论检查前1天晚上9点大黄穴位贴敷联合检查当天早上5~7点口服PGEP对便秘患者行结肠镜检查肠道准备效果好。     

Acupoint catgut embedding therapy for functional constipation: A protocol for systematic review and meta-analysis

Background:This review will assess current evidence related to the effectiveness and safety of acupoint catgut embedding therapy for functional constipation (FC) and provide efficacy assessments for clinical applications.Methods:We will search the following databases for relevant trials: PubMed, EMBASE OVID, Cumulative Index of Nursing and Allied Health Literature, OVID MEDLINE, Web of Science, the Cochrane Central Register of Controlled Trials, Cochrane library, and Scopus. We will also search the following Chinese databases for trials published in the Chinese literature: China National Knowledge Infrastructure Database (CNKI), Chinese Scientific Journals Database, Wan Fang Database, Chinese Biomedicine and other resources from inception to December 2020. Only randomized controlled trials comparing acupoint catgut embedding versus acupuncture or sham acupuncture or placebo or other therapies will be included. The outcomes involved mean spontaneous bowel movements, complete spontaneous bowel movements, the Bristol Stool Form Scale, the Cleveland Clinic Score, Patient Assessment of Constipation symptom and so on. The risk of bias assessment and quality of evidence for outcomes will be appraised using the Cochrane Risk of Bias Tool and the Grading of Recommendations, Assessment, Development and Evaluation guidelines. RevMan 5.3 software will be employed for the meta-analysis.Results:This work will compare and arrange the comparative efficacy of acupoint catgut embedding with different treatments for FC by summarizing the current evidences.Conclusion:The results of this meta-analysis may help doctors determine the best treatments for patients to manage FC.Ethics and dissemination:This is a protocol with no patient recruitment and personal information collection, approval by the ethics committee is not required.OSF Registration number:DOI 10.17605/OSF.IO/XTKE2.     

The study on the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of nerve root sciatica: A protocol for systematic review and meta-analysis of randomized controlled trials

Background:Nerve root sciatica (NRS) is a common orthopedic disease, which usually occurs between 20 and 40 years of age, and the incidence rate is increasing year by year and is being younger. The disease has no special effect of treatment, clinically generally taking the symptomatic treatment, such as taking short-term glucocorticoids, sedatives, analgesics, and so on. Long-term use of drugs will adversely affect the patient''s gastrointestinal tract, liver, and kidney function. The surgical treatment has a high risk of surgery, high cost, side effects, and other problems, so the choice of treatment method has always been a difficult problem in clinical and scientific research. The study shows that 90% of patients with sciatica can be cured by non-surgical treatment, so conservative therapy is often used in the treatment of sciatica, traditional Chinese medicine treatment methods in the treatment of NRS has been widely used, which has achieved good results, but there is no evidence of evidence-based medicine. Therefore, this study uses systematic evaluation to conduct the scientific evaluation of the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS, and provide evidence-based medical evidence support for the treatment of NRS.Methods:Using the computer to retrieve the PubMed, ScienceDirect, Web of Science, Embase, Cochrane Library, CNKI, VIP, WANFANG Database, and CBM. Using the subject words and terminology words to retrieve the Chinese-English database and retrieve a randomized controlled study on the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS, and the range of search time is January 1990 to January 2021. The searched literature is screened and evaluated by two researchers respectively according to the inclusion and exclusion criteria. If there is disagreement, discussing it with the third researcher to determine the final inclusion of the literature. Using the RevMan 5.3 software to conduct the meta-analysis.Results:This study will compare the effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS.Conclusion:The results of this study will be published in internationally influential academic journals to provide evidence-based medical evidence for the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding in the treatment of NRS.Ethics and dissemination:This study does not involve specific patients, and all research data comes from publicly available professional literature, so an ethics committee is not required to conduct an ethical review and approval of the study.OSF registration number:DOI 10.17605/OSF.IO/Q492E.     

电针结合穴位敷贴治疗肛肠手术后便秘临床观察

目的观察电针结合穴位敷贴治疗肛肠手术后便秘的临床疗效。方法 100例肛肠手术后便秘患者随机分为两组。治疗组采用针刺双侧天枢、足三里、上巨虚,同时在两侧天枢及上巨虚采取电针治疗,治疗30min后,将中药敷贴贴于神阙穴上;对照组采用开塞露灌肠治疗。2个疗程后比较两组治疗效果,及治疗前后排便次数、排便困难程度的变化。结果治疗组总有效率与对照组比较有明显差异(P0.05);治疗后两组排便次数较治疗前有明显变化(P0.05);治疗组治疗后排便困难程度积分较治疗前比较有明显差异(P0.05),对照组无明显变化。结论电针结合穴位敷贴是一种治疗肛肠手术后便秘的有效方法。     

本经取穴调控无先兆偏头痛患者基因表达谱的研究

【目的】研究针刺少阳经穴与针刺非经非穴治疗无先兆偏头痛患者前后的基因表达谱。【方法】采用基因芯片技术,分析比较采用经穴（经穴组）和非经非穴（非经非穴组）治疗无先兆偏头痛患者（各10例）后基因表达谱的差异;选取部分基因进行Real-time聚合酶链反应（RT－PCR）,验证基因芯片结果的准确性。【结果】经穴组治疗前后筛选出72个差异基因;非经非穴组治疗前后筛选出110个差异基因。经穴组差异基因涉及的功能包括脑内啡肽酶、 ATP合酶等,与治疗该病的关联性大。但非经非穴组涉及的基因功能广泛且分散,与治疗该病关联性较小,如细胞凋亡、 DNA修复等。 RT－PCR检测了经穴组的ATPAF2、 PTGS2、 TOR3A基因,非经非穴组的ACP2、 AURKA、 ARHGEF11、 CASP8基因,验证了基因芯片数据的可靠性。【结论】本经取穴治疗无先兆偏头痛的经穴效应在分子水平是多基因作用的综合结果,而非经非穴产生的安慰效应并未找到与之对应的与治疗无先兆偏头痛相关的靶基因,进一步证明了经穴效应的存在。     

表里经配穴法对脑缺血再灌注损伤大鼠海马细胞凋亡及JNK信号通路的影响

【目的】观察表里经配穴法对脑缺血再灌注损伤大鼠海马细胞凋亡及c－jun氨基末端激酶（JNK）信号通路的影响,探讨其对脑缺血再灌注损伤保护作用的可能机制。【方法】将120只SD大鼠随机分为假手术组、模型组、表里经配穴电针组、抑制剂组;参照Longa法复制局灶脑缺血再灌注模型,表里经配穴电针组取表里经配穴的足三里、三阴交和尺泽、合谷行电针治疗,每日1次。采用神经行为学评定各组大鼠不同时段神经行为, TUNEL法检测海马细胞凋亡指数,免疫组织化学法检测p－JNK表达。【结果】表里经配穴电针组、抑制剂组神经功能缺损评分均显著低于模型组（P＜0．05）;模型组凋亡指数显著高于假手术组（P＜0．01）,表里经配穴电针组和抑制剂组凋亡指数均显著低于模型组（P＜0．05）;模型组各时段p－JNK表达较假手术组显著增加（P＜0．01）,表里经配穴电针组、抑制剂组p－JNK表达较模型组显著降低（P＜0．05）。【结论】表里经配穴法可不同程度地减轻缺血再灌注后大鼠的神经功能缺损,减少细胞凋亡,其机制可能与抑制JNK信号通路有关。     

加味赤石脂禹余粮汤联合热敏灸治疗肝硬化腹水并顽固性腹泻疗效观察

【目的】观察加味赤石脂禹余粮汤联合热敏灸对肝硬化腹水并顽固性腹泻的临床疗效。【方法】选择肝硬化腹水并顽固性腹泻患者60例,随机分为治疗组与对照组各30例,对照组采用西医常规疗法加中药加味赤石脂禹余粮汤治疗,治疗组在对照组治疗基础上加用热敏灸疗法,观察2组患者腹泻、腹水及肝功能指标[总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)、前白蛋白(PA)]改善情况。【结果】(1)腹泻疗效:治疗组总有效率为100.00%,优于对照组的86.67%(P<0.05)。(2)腹水疗效:经彩超检查,治疗后2组的肝硬化腹水均有显著改善(P<0.05),且治疗组疗效优于对照组(P<0.05)。(3)肝功能作用:治疗后,2组TBIL、ALT、AST、ALB、PA指标均显著改善(P<0.05),且治疗组的改善作用均优于对照组(P<0.05)。(4)不良反应及随访情况:治疗过程中,治疗组与对照组均未发生明显不良反应。3个月后随访,对照组腹泻治愈患者中复发5例,治疗组无复发病例。【结论】加味赤石脂禹余粮汤联合热敏灸对肝硬化腹水并顽固性腹泻患者疗效显著,具有止泻迅速、应用方便、安全可靠等优点,并且有加速腹水消退、促进肝功能恢复的作用。     

针灸治疗干眼症

目的 总结近5年针灸治疗干眼症的临床研究进展,并提出存在问题与研究展望.方法 检索2008年1月-2013年6月发表的针灸治疗干眼症的临床研究文献,从临床疗效、临床操作、诊疗标准及作用机制角度进行探讨.结果 针灸治疗干眼症以眼周局部取穴为主,常用穴位有睛明、攒竹、太阳等,配穴以局部和远端取穴相结合为主,但诊疗标准缺乏统一,机制研究较少,有待进一步完善.结论 针灸通过刺激神经兴奋,促进泪腺、睑板腺主动分泌泪液,双向调节性激素水平等环节起到缓解眼部症状的功效.