老年高血压妇女内皮功能、血小板活化状态及雌激素的影响

目的：了解老年高血压妇女内皮功能和血小板活化状态，以及雌激素治疗的影响。方法：已接受降压治疗的78例老年高血压妇女随机分为两组，均继续服用降压药，A组加服尼尔雌醇，B组加服安慰剂，疗程为6个月。治疗前后观察血浆一氧化氮（NO）、血管性血友病因子（vWF)、P选择素（P－selectin)和纤维蛋白原（Fbg)浓度变化。24例健康体检者作为正常对照组。结果：高血压vWF,P-selectin和Fbg显著高于对照组，NO显著低于对照组；治疗后A组vWF和P-selectin显著降低，NO明显升高，与B组比较有显著性差异。结论：已接受降压治疗的老年高血压妇女仍存在内皮损害和血小板活化，尼尔雌醇治疗具有明确的有益作用。     

营养不良的胃肠形态和功能

蛋白质－热能营养不良是儿科常见疾病之一，它与胃肠道形态和功能有密切联系。营养不良可引起胃肠形态异常和功能障碍，而胃肠道形态异常又可引起营养物质吸收障碍，从而进一步造成营养不良。我们认为了解营养不良的胃肠形态和功能有助于儿科医师对本病的治疗。     

Multiple digital fractures from automobile air bag inflation

Automobile air bag inflation-caused injuries to the chest, neck, and face, in particular the orbital contents, are infrequent but recognized. We report the occurrence of multiple digital fractures in the left hand of a 30-yearold male driver as a result of sudden air bag inflation. Continued monitoring of the potential hazards of this device is suggested.     

境外医院领导体制概述

介绍了境外部分国家和地区的医院类型、政府在医院管理中的职能和有关医院领导体制的基本情况,侧重介绍了医院最高领导机构和决策者的组成和特征。指出:要转变政府职能,强调医院的自主经营和自主管理,医院的发展需要有一支高效率、高管理水平的医院领导队伍。     

Imaging studies of the cadaver hand using transmission ultrasound

Ultrasonic transmission imaging has already demonstrated potential for evaluating structures in the hand. In this study, a cadaver hand was imaged using a transmission scanner with improved imaging capability. The hand was then frozen and serially sectioned and comparisons were made between the sectional anatomy and the corresponding image. Bone (in silhouette), muscle, cartilage, and tendon were visualized with high resolution.     

手烧伤晚期功能重建

目的：探讨一种科学的方法对手烧伤晚期畸形进行功能重建。方法：采用了手术与非手术相结合的方法，对62例病人，80只手烧伤晚期功能障碍进行重建。结果：局部改形31例，大张全厚或中厚植皮27例，皮瓣移植4例，手术均成功，术后注重康复治疗，畸形改善，功能得到最大限度恢复。结论：手烧伤晚期功能重建如何，烧伤早期正确处理是基础，整形手术是关键，康复治疗是保障。     

Modulation of cutaneous reflexes in arm muscles during walking: further evidence of similar control mechanisms for rhythmic human arm and leg movements

Stimulation of cutaneous nerves innervating the hand evokes prominent reflexes in many arm muscles during arm cycling. We hypothesized that the mechanisms controlling reflex modulation during the rhythmic arm swing of walking would be similar to that documented during arm cycling. Thus, we expected cutaneous reflexes to be modulated by position in the walking cycle (phase dependence) and be different when walking compared to contraction while standing (task dependence). Subjects performed static postures similar to those occurring during walking and also walked on a treadmill while the superficial radial nerve was electrically stimulated pseudorandomly throughout the step cycle. EMG was recorded bilaterally from upper limb muscles and kinematic recordings were obtained from the elbow and shoulder joints. Step cycle information was obtained from force-sensing insoles. Analysis was conducted after averaging contingent upon the occurrence of stimulation in the step cycle. Phase-dependent modulation of cutaneous reflexes at early (~50–80 ms) and middle (~80–120 ms) latencies was observed. Coordinated bilateral reflexes were seen in posterior deltoid and triceps brachii muscles. Task dependency was seen in that reflex amplitude was only correlated with background EMG during static contraction (75% of comparisons for both early and middle latency reflexes). During walking, no significant relationship between reflex amplitude and background EMG level was found. The results show that cutaneous reflex modulation during rhythmic upper limb movement is similar to that seen during arm cycling and to that observed in leg muscles during locomotion. These results add to the evidence that, during cyclical movements of the arms and legs, similar neural mechanisms observed only during movement (e.g. central pattern generators) control reflex output. Electronic Publication     

HESR1基因在血管新生中作用的初步研究

目的研究转录因子HESR1在血管新生中的作用。方法检测内皮细胞激活状态HESR1表达的影响,克隆HESR1基因,转染到HUVEC,绿色荧光和PCR观察HESR1在内皮细胞的表达,流式细胞仪检测它对血管内皮细胞增殖,boyden小室检测对细胞迁移的影响,建体外二维血管模型,观察HESR1对血管形成的影响。结果内皮细胞激活状态HESR1的表达下降,HESR1基因能抑制内皮细胞的增殖和迁移,减少血管新生。结论HESR1基因通过抑制内皮细胞的增殖和迁移,使内皮细胞从激活状态转入安静状态,减少血管的形成,维持血管的稳定状态。     

Worry研究的新进展

Worry具有难以控制性和持续性的特点。其机制既有自动的加工过程也包含控制的加工过程。高Worry倾向者对否定性信息具有过度的选择性注意,其结果是限制了问题的解决、增强了Worry的唯以控制感;高Worry倾向者确定问题解决策略的持续时间校长,从而造一步增强了解决问题的动机．长时间的持续思考增强了Worry的难以控制感。     

Effects of methylprednisolone on the neural conduction of the motor evoked potentials in spinal cord injured rats

Methylprednisolone(MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury(SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to saline-treated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI.