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991.
3-氯-4-氟苯胺亚甲基丙二酸二乙酯在惰性高沸点溶剂中的环化反应 总被引:1,自引:1,他引:0
用 ~1HNMR 方法测定了3-氯-4-氟苯胺亚甲基丙二酸二乙酯在二苯醚或石蜡油中加热环化所得产物中2与3的比例,结果表明此比例随着溶剂的不同而稍有变化,并且副产物3的组份随着溶剂用量增大而减少。 相似文献
992.
Yuan Xue Tracy L. Williams Ting Li Joshua Umbehr Liang Fang Weiqun Wang Richard C. Baybutt 《Toxicology in vitro》2005,19(8):1061-1069
This study was to evaluate the effects of cigarette smoke constituents upon type II pneumocyte surfactant production in vitro, and how vitamins A and E may alter the response. Freshly isolated type II pneumocytes from Sprague–Dawley rats were incubated 20 h in medium with fetal bovine serum that was or was not treated with cigarette smoke. The number of adherent cells was inversely related to the dose of smoke or benzo(a)pyrene. Despite the decreased number of treated cells, the total amount of surfactant per culture well was unchanged, whereas surfactant production per cell was significantly increased (P < 0.05). Vitamin A concentration was significantly (P < 0.05) lower in the smoke-treated serum compared with untreated serum. When vitamin A or E was added to the cigarette smoke-treated serum, cell adherence and surfactant production returned to control values. In conclusion, cigarette smoke constituents or benzo(a)pyrene alone decreased the number of adherent type II pneumocytes, but did not alter surfactant amounts because of an increased production of surfactant per cell. Type II pneumocytes seem to adjust surfactant production dependent upon the number of type II pneumocytes to produce it and vitamin A or E enhance cell attachment in the presence of the smoke toxins. 相似文献
993.
目的研究我国汉族人纤溶酶原激活物抑制物-1基因启动子区-675位4G/5G(单鸟嘌呤核苷酸插入/缺失)基因多态性与心肌梗死和脑梗死的等位基因特异性的相关性.方法以等位基因特异性聚合酶链反应(AS-PCR)扩增56例心肌梗死患者,54例脑梗死患者,83例无关健康对照个体的基因组DNA,鉴定PAl-1 4G/5G基因型及分布频率,常规方法检验研究个体的主要临床和生化指标.结果PAI-1基因启动子区4G/5G基因多态性在心肌梗死,脑梗死患者组中的分布频率与对照组明显不同.在心肌梗死组中,4G/4G基因型分布频率(71.40%)比对照组(30.12%)显著增加(P<0.001),杂合型4G/5G基因型分布频率(25.00%)比对照组(62.65%)明显降低;而在脑梗死组中,4G/4G,4G/5G基因型分布频率(分别为20.37%,55.56%)均比对照组(分别为30.12%,62.65%)低,5G/5G基因型明显增加(24.07%vs7.32%,P<0.001).而且心梗组中血浆PAI-1活性水平随着4G等位基因的减少而降低;脑梗死组中,血浆PAI-1活性水平随着5G等位基因的升高而增加.心肌梗死、脑梗死患者组中的血浆PAI-1活性水平,甘油三酯水平和血糖水平都比对照组明显升高(分别为P<0.001,P<0.05,P<0.001).结论本研究表明,中国汉族人PAI-1基因启动子区4G/5G基因多态性可能和心肌梗死、脑梗死发生的危险性相关,4G/5G基因多态性可能是一种重要的遗传性血栓性疾病的危险因子. 相似文献
994.
Novel techniques have recently emerged to separate chiral drug compounds into pure enantiomers. The mechanism, experimental difficulties, and applicability of these methods can vary greatly, and the choices involved are not straightforward. The most significant new advances in the field of chiral separations have come from work done with liquid chromatographic systems and chiral stationary-phase columns. This review describes several commonly used approaches to chiral separation, diastereomeric derivatization, chiral mobile-phase additives, and three major types of chiral stationary phases. Although no single method can be judged superior for every drug application, it appears that chiral stationary phases have received the most attention recently and they are emphasized here. 相似文献
995.
In an attempt to clarify the role of 5-hydroxytryptamine (5-HT) in the discriminative stimulus properties of MK 212 (6-chloro-2[1-piperazinyl]pyrazine), male Sprague-Dawley rats were trained to discriminate 0.5 mg/kg of this compound from saline. While the putative 5-HT agonists fenfluramine and m-chlorophenylpiperazine (MCPP) mimicked MK 212 in a dose-related manner, d-lysergic acid diethylamide (LSD), 8-hydroxy-2(di-n-propylamino)tetralin (8-OHDPAT), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), quipazine, Ru 24969, and 1-(m-trifluoromethylphenyl)piperazine (TFMPP) failed to substitute completely. The 5-HT1/5-HT2 antagonists BC 105, metergoline, and methysergide completely blocked the MK 212 cue, while the selective 5-HT2 antagonists ketanserin and pirenperone, the dopamine antagonists haloperidol and spiperone, and the beta-noradrenergic antagonist propranolol were without effect. The substitutions of fenfluramine and MCPP for MK 212 support a role for 5-HT in the MK 212 cue; however, the lack of substitution of many other 5-HT agonists is difficult to explain. The complete antagonism by 5-HT1/5-HT2 but not by selective 5-HT2, antagonists suggests the possibility that 5-HT1 receptors mediate the stimulus properties of MK 212. Further research is needed to support this hypothesis and to investigate the relative role of 5-HT and other neurotransmitters in the stimulus effects of MK 212.Portions of this research were presented at the Meeting of the Committee on Problems of Drug Dependence Satellite Session (International Study Group Interested in Drugs as Reinforcers and the Society for the Stimulus Properties of Drugs) in Baltimore, MD (1985) 相似文献
996.
Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi 总被引:6,自引:0,他引:6
R Docampo S N Moreno J F Turrens A M Katzin S M Gonzalez-Cappa A O Stoppani 《Molecular and biochemical parasitology》1981,3(3):169-180
Miconazole and econazole, two fungicide imidazole derivatives, completely inhibited growth of Trypanosoma cruzi (Tulahuen strain) at concentrations of about 20 muM. Culturing of T. cruzi in the presence of lower doses of imidazole derivatives produced: decrease of 5,7-diene sterol content in epimastigotes (including ergosterol); disappearance of the nuclear chromatin, vacuolization and decrease in the electron density of the cytoplasm; selective surface alterations as revealed by an increased response to wheat-germ- and phytohemagglutinin. At variance with the effect of miconazole on Candida (De Nollin et al. (1977) Antimicrobial. Agents Chemother. 11, 500-513), miconazole and econazole, under the experimental conditions used, did not increase the rate of hydrogen peroxide generation by T. cruzi. 相似文献
997.
M. Rothmund 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1986,369(1):681-685
Zusammenfassung Die Indikation zur Operation bei der AHNP ist bestimmt durch den Schweregrad und die Verlaufsdynamik der Erkrankung: Beides muß täglich neu kontrolliert und abgeschätzt werden, wobei hilfreiche Parameter vor allem das klinische Bild und einfache Labordaten sind. Die Computertomographie trägt nur bedingt zur Indikation bei. Eine Frühoperation ist indiziert bei Versagen der Intensivtherapie, Sepsis und vor allem bei drohender Nieren- und Lungeninsuffizienz. Eine Operation im postakuten Stadium sollte ebenfalls bei septischen Komplikationen durchgeführt werden. Engmaschige Verlaufskontrollen sind hier erforderlich.
Indication for surgery in acute pancreatitis
Summary The indication for surgery in acute hemorrhagic necrotizing pancreatitis (AHNP) depends on the severity of the disease and the clinical course. Both factors must be determined daily, based on clinical and laboratory data. CAT-scan does not contribute much to indication. An early operation is necessary if despite an optimal intensive care septic symptoms and signs persist and renal and respiratory failure occur. Surgery is indicated 2–3 weeks after onset of AHNP if septic complications (re)-occur. A close follow up is mandatory.相似文献
998.
999.
1000.
笔总结了2000年5月-2002年3月收治的9例口服苯丙胺中毒患救护成功的体会。(1)及早,彻底,反复洗胃,有效清除消化吸收的毒物,洗胃过程中做好安全约束措施,使洗胃能顺利完成,对中毒较深的病人结合床边血液透析,以提高疗效。(2)迅速建立静脉通路,合理使用安定,利尿剂,激素,加强对症处理。(3)严密观察病情变化,保持呼吸道通畅。(4)做好基础护理,安全保护及心理护理,9例患均治愈出院。 相似文献