Intermediate filament proteins in developing human arteries

 The distribution of intermediate filament proteins in adult human blood vessels and in human fetal elastic arteries is relatively well-known. However, the distribution of these proteins in the course from neonate to adult has not been established. In this investigation, human postnatal arteries were studied with immunohistochemistry, using antibodies targeted on the intermediate filament proteins desmin, vimentin and cytokeratins 8, 18 and 19. Vimentin was present in most smooth muscle cells in all vessels and at all ages. The proportions of desmin-expressing cells increased in the elastic arteries during the first year of life and was higher in the pulmonary trunk than in the aorta. In the muscular arteries, the proportion of desmin-labelled cells increased in the coronary and the deep femoral arteries, but remained constant in the renal and the cerebral arteries. Cytokeratins were detected in the pulmonary trunk earlier than in the aorta. Cytokeratins were present throughout the wall of the ductus arteriosus, but desmin was present only in some cells. Thus, there are postnatal changes in the distribution of intermediate filament proteins in the elastic arteries and in some muscular arteries, whereas the intermediate filament pattern remains unchanged in other muscular arteries. Accepted: 31 July 1998     

应用Amplatzer封堵器治疗动脉导管未闭

目的 评价Ａｍｐｌａｔｚｅｒ封堵器治疗动脉导管未闭的初步疗效。方法 经导管置入Ａｍｐｌａｔｚｅｒ封堵器治疗ＰＤＡ共２６例。结果 全组２６例堵堵器均放置成功。造影示分流完全消失１６例（６１％）,微量残余分流８例（３１％）,少量残余分流２例（８％）。术后２４￣４８小时多普勒超声示分流完全消失２４例（９２％）,微量残余分流２例（８％）。１便封堵术后１７小时发生溶血,５４小时后行外科ＰＤＡ缝合术。结论应用     

应用Amplatzer封堵器治疗动脉导管未闭的疗效评价

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彩色超声对小儿动脉导管未闭封堵术的疗效评价

目的 应用彩超评价小儿动脉导管未闭封堵术的疗效。方法 ２２例动脉导管未闭（ＰＤＡ）患儿经导管用３种方法（弹簧圈法、蘑圈法、蘑菇伞法、海绵塞法）进行封堵。超声心动图检查示１７例患儿ＰＤＡ为管形,５例为漏斗形,直径为１．９～５．２ｍｍ,平均（３．５℃０．９）ｍｍ,６例采用蘑菇伞法,１０例采用弹簧圈法,６例采用海绵塞法,分别于术前、术后３ｄ、１月、半年复查超声心动图,观察大动脉水平有无分流及心脏大小变化     

深静脉导管的相关因素及护理

深静脉置管由于保留时间长、输液种类广泛、导管弹性好等优点,在胃肠外高价营养、中心静脉压监测、危重患者抢救等方面已广泛应用并逐步扩大,取得了较好的效果.但中心静脉导管感染是深静脉置管术较常见和严重的并发症.其与操作及护理有关.     

胸腔灌注化疗治疗晚期肺癌并胸腔积液的临床观察

目的：观察胸腔灌注化疗治疗晚期肺癌合并胸腔积液的安全性、有效性及毒副反应.方法： 胸腔穿刺植入外周置入的中心静脉导管（PICC）,引流干净胸腔积液后灌注顺铂（DDP）和高聚金葡素,副作用主要为恶心、呕吐和白细胞减少.结论：经皮胸腔内埋置中心静脉导管化疗是一种安全有效的方法,值得在临床上进步研究应用.     

超声测量胎儿静脉导管血流动力学参数联合血清胎盘生长因子预测妊娠期高血压疾病患者妊娠结局的价值

目的 探讨超声测量胎儿静脉导管血流动力学参数联合血清胎盘生长因子（PLGF）预测妊娠期高血压疾病（HDP）患者妊娠结局的价值。方法 回顾性分析2022年4月—2023年4月在承德市中心医院产检诊断为HDP的80例患者的临床资料,将其作为研究组。另取同期该院健康产检孕妇100例作为对照组。比较两组胎儿静脉导管血流动力学参数[搏动指数（PI）、阻力指数（RI）、血流速度峰谷比（S/D）、静脉导管分流率]、血清PLGF水平及不良妊娠结局发生率。根据HDP患者妊娠结局分为不良结局组（18例）、结局良好组（62例）。比较两组基线资料、胎儿静脉导管血流动力学参数、PLGF水平,绘制受试者工作特征（ROC）曲线分析胎儿静脉导管血流动力学参数及血清PLGF水平预测HDP患者不良妊娠结局的价值,采用多因素逐步Logistic回归模型分析HDP患者不良妊娠结局的危险因素。结果 研究组胎儿静脉导管血流动力学参数（PI、RI、S/D、静脉导管分流率）均高于对照组（P <0.05）,血清PLGF水平低于对照组（P <0.05）。研究组不良妊娠结局发生率高于对照组（P <0.05）。不良结局组年...